The differential effects of metronomic gemcitabine and antiangiogenic treatment in patient-derived xenografts of pancreatic cancer: treatment effects on metabolism, vascular function, cell proliferation, and tumor growth

Angiogenesis

Volumn 19, Issue 2, 2016, Pages 229-244

  Yapp, Donald T ^a,b   Wong, May Q ^a   Kyle, Alastair H ^a   Valdez, Shannon M ^a   Tso, Jenny ^b   Yung, Andrew ^b   Kozlowski, Piotr ^b   Owen, David A ^b   Buczkowski, Andrzej K ^b   Chung, Stephen W ^b   Scudamore, Charles H ^b   Minchinton, Andrew I ^a   Ng, Sylvia S W ^c  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Anti angiogenesis; Gemcitabine; Metronomic chemotherapy; MRI; Pancreatic cancer; Patient derived xenografts; PET CT; Tumor physiology

Indexed keywords

GEMCITABINE; MONOCLONAL ANTIBODY DC101; ANGIOGENESIS INHIBITOR; DC101 MONOCLONAL ANTIBODY; DEOXYCYTIDINE; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC THERAPY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLOOD FLOW; CANCER GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; GLUCOSE METABOLISM; HUMAN; HUMAN TISSUE; HYPOXIA; IMMUNOFLUORESCENCE MICROSCOPY; METABOLISM; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS CANCER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TREATMENT RESPONSE; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; VASCULAR FUNCTION; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; DRUG SCREENING; MALE; METRONOMIC DRUG ADMINISTRATION; MICROVASCULATURE; NECROSIS; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; PATHOLOGY; PERFUSION; SCID MOUSE; VASCULARIZATION;

ADMINISTRATION, METRONOMIC; ANGIOGENESIS INHIBITORS; ANIMALS; ANTIBODIES, MONOCLONAL; CELL PROLIFERATION; DEOXYCYTIDINE; HUMANS; MALE; MICE, SCID; MICROVESSELS; NECROSIS; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; PERFUSION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84960171935     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-016-9503-z     Document Type: Article

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