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Volumn 9, Issue 11, 2009, Pages 1347-1356

VEGF as an inhibitor of tumor vessel maturation: Implications for cancer therapy

Author keywords

Mural cells; Normalization; PDGF; Pericytes; Tumor angiogenesis; VEGF

Indexed keywords

AFLIBERCEPT; ALPHA INTERFERON; ANGIOGENESIS INHIBITOR; BASIC FIBROBLAST GROWTH FACTOR; BEVACIZUMAB; CARBOPLATIN; CT 322; FLUOROURACIL; FOLINIC ACID; IMC 1121B; IRINOTECAN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY DC101; PACLITAXEL; PLATELET DERIVED GROWTH FACTOR; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VATALANIB;

EID: 70350655979     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712590903208883     Document Type: Review
Times cited : (59)

References (71)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285(21):1182-1186
    • (1971) N Engl J Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 2
    • 0016327922 scopus 로고
    • A simple procedure for the long-term cultivation of chicken embryos
    • Auerbach R, Kubai L, Knighton D, et al. A simple procedure for the long-term cultivation of chicken embryos. Dev Biol 1974;41:391-394
    • (1974) Dev Biol , vol.41 , pp. 391-394
    • Auerbach, R.1    Kubai, L.2    Knighton, D.3
  • 3
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman J, Klagsburn M. Angiogenic factors. Science 1987;235:442-447
    • (1987) Science , vol.235 , pp. 442-447
    • Folkman, J.1    Klagsburn, M.2
  • 4
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, et al. Vascular endothelial growth factor is a secreted angiogenic molecule. Science 1989;246:1306-1309 (Pubitemid 20066716)
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.-J.3    Goeddel, D.V.4    Ferrara, N.5
  • 5
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983;219:983-985
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3
  • 6
    • 0017748317 scopus 로고
    • Partial purification and characterization of platelet factors stimulating the multiplication of normal human glial cells
    • Heldin CH, Wasteson A, Westermark B. Partial purification and characterization of platelet factors stimulating the multiplication of normal human glial cells. Exp Cell Res 1977;109(2):429-437 (Pubitemid 8222981)
    • (1977) Experimental Cell Research , vol.109 , Issue.2 , pp. 429-437
    • Heldin, C.H.1    Wasteson, A.2    Westermark, B.3
  • 7
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • DOI 10.1038/362841a0
    • Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor in induced angiogenesis suppresses tumour growth in vivo. Nature 1993;362:841-844 (Pubitemid 23132159)
    • (1993) Nature , vol.362 , Issue.6423 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 9
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • Levy AP, Levy NS, Wegner S, Goldberg MA. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 1995;270:13333-13340
    • (1995) J Biol Chem , vol.270 , pp. 13333-13340
    • Levy, A.P.1    Levy, N.S.2    Wegner, S.3    Goldberg, M.A.4
  • 11
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
    • DOI 10.1016/0092-8674(93)90573-9
    • Millauer B, Wizigmann-Voos S, Schnurch H. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993;72:835-846 (Pubitemid 23110226)
    • (1993) Cell , vol.72 , Issue.6 , pp. 835-846
    • Millauer, B.1    Wizigmann-Voos, S.2    Schnurch, H.3    Martinez, R.4    Moller, N.P.H.5    Risau, W.6    Ullrich, A.7
  • 12
    • 0031466232 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells
    • DOI 10.1074/jbc.272.51.32521
    • Kroll J, Waltenberger J. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem 1997;272(51):32521-32527 (Pubitemid 28011938)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.51 , pp. 32521-32527
    • Kroll, J.1    Waltenberger, J.2
  • 13
    • 0028170578 scopus 로고
    • Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor
    • DOI 10.1006/bbrc.1994.2726
    • Dougher-Vermazen M, Hulmes JD, Böhlen P, et al. Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF receptor. Biochem Biophys Res Commun 1994;205:728-738 (Pubitemid 124009490)
    • (1994) Biochemical and Biophysical Research Communications , vol.205 , Issue.1 , pp. 728-738
    • Doughervermazen, M.1    Hulmes, J.D.2    Bohlen, P.3    Terman, B.I.4
  • 14
    • 0033393771 scopus 로고    scopus 로고
    • Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
    • Eliceiri BP, Paul R, Schwartzberg PL, et al. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 1999;4:915-924 (Pubitemid 30054898)
    • (1999) Molecular Cell , vol.4 , Issue.6 , pp. 915-924
    • Eliceiri, B.P.1    Paul, R.2    Schwartzberg, P.L.3    Hood, J.D.4    Leng, J.5    Cheresh, D.A.6
  • 16
    • 0028788570 scopus 로고
    • Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
    • Henkemeyer M, et al. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature 1995;377:695-701
    • (1995) Nature , vol.377 , pp. 695-701
    • Henkemeyer, M.1
  • 17
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-1- D e ficient mice
    • Shalaby F, Rossant J, Yamaguchi TP, et al. Failure of blood-island formation and vasculogenesis in Flk-1- d e ficient mice. Nature 1995;376:62-66
    • (1995) Nature , vol.376 , pp. 62-66
    • Shalaby, F.1    Rossant, J.2    Yamaguchi, T.P.3
  • 18
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995;376:66-70
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 21
    • 34547671040 scopus 로고    scopus 로고
    • Vascular endothelial cell growth factor-a: Not just for endothelial cells anymore
    • D'Amore PA. Vascular endothelial cell growth factor-a: not just for endothelial cells anymore. Am J Pathol 2007;171(1):1
    • (2007) Am J Pathol , vol.171 , Issue.1 , pp. 1
    • D'Amore, P.A.1
  • 23
    • 0030862157 scopus 로고    scopus 로고
    • Vascular endothelial growth factor increases the mitogenic response to fibroblast growth factor-2 in vascular smooth muscle cells in vivo via expression of fms-like tyrosine kinase-1
    • Couper LL, Bryant SR, Eldrup-Jorgenson J, et al. Vascular endothelial growth factor increases the mitogenic response to fibroblast growth factor-2 in vascular smooth muscle cells in vivo via expression of fms-like tyrosine kinase-1. Circ Res 1997;81:932-939
    • (1997) Circ Res , vol.81 , pp. 932-939
    • Couper, L.L.1    Bryant, S.R.2    Eldrup-Jorgenson, J.3
  • 24
    • 2942676788 scopus 로고    scopus 로고
    • The PDGF family: Four gene products form five dimeric isoforms
    • DOI 10.1016/j.cytogfr.2004.03.007, PII S1359610104000176
    • Fredriksson L, Li H, Eriksson U. The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev 2004;15(4):197-204 (Pubitemid 38781045)
    • (2004) Cytokine and Growth Factor Reviews , vol.15 , Issue.4 , pp. 197-204
    • Fredriksson, L.1    Li, H.2    Eriksson, U.3
  • 27
    • 0032875460 scopus 로고    scopus 로고
    • Mechanism of action and in vivo role of platelet-derived growth factor
    • Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999;79(4):1283-1316 (Pubitemid 29473317)
    • (1999) Physiological Reviews , vol.79 , Issue.4 , pp. 1283-1316
    • Heldin, C.-H.1    Westermark, B.2
  • 28
    • 0346333243 scopus 로고    scopus 로고
    • Inhibition of Platelet-Derived Growth Factor Receptor Phosphorylation by STI571 (Gleevec) Reduces Growth and Metastasis of Human Pancreatic Carcinoma in an Orthotopic Nude Mouse Model
    • Hwang RF, Yokoi K, Bucana CD, et al. Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model. Clin Cancer Res 2003;9(17):6534-6544 (Pubitemid 38031842)
    • (2003) Clinical Cancer Research , vol.9 , Issue.17 , pp. 6534-6544
    • Hwang, R.F.1    Yokoi, K.2    Bucana, C.D.3    Tsan, R.4    Killion, J.J.5    Evans, D.B.6    Fidler, I.J.7
  • 29
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, et al. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003111(9):1287-1295
    • (2003) J Clin Invest , vol.111 , Issue.9 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3
  • 30
    • 34547637867 scopus 로고    scopus 로고
    • Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102
    • DOI 10.1158/0008-5472.CAN-07-0293
    • Sennino B, Falcón BL, McCauley D, et al. Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res 2007;67(15):7358-7367 (Pubitemid 47206566)
    • (2007) Cancer Research , vol.67 , Issue.15 , pp. 7358-7367
    • Sennino, B.1    Falcon, B.L.2    McCauley, D.3    Le, T.4    McCauley, T.5    Kurz, J.C.6    Haskell, A.7    Epstein, D.M.8    McDonald, D.M.9
  • 31
    • 0242456268 scopus 로고    scopus 로고
    • Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival
    • Darland DC, Massingham LJ, Smith SR, et al. Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol 2003;264:275-288
    • (2003) Dev Biol , vol.264 , pp. 275-288
    • Darland, D.C.1    Massingham, L.J.2    Smith, S.R.3
  • 32
    • 0035347301 scopus 로고    scopus 로고
    • Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival
    • Reinmuth N, Liu W, Jung YD, et al. Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival. FASEB J 2001;15:1239-1241
    • (2001) FASEB J , vol.15 , pp. 1239-1241
    • Reinmuth, N.1    Liu, W.2    Jung, Y.D.3
  • 35
    • 55449098072 scopus 로고    scopus 로고
    • Chick embryo chorioallantoic membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector molecules
    • 2008, Chapter 2 Elsevier
    • Deryugina EI, Quigley JP. Methods in enzymology angiogenesis: in vivo systems, Part A. Volume 444, 2008, Chapter 2 Chick embryo chorioallantoic membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector molecules. Elsevier; 2008. p. 21-41
    • (2008) Methods in Enzymology Angiogenesis: In Vivo Systems, Part A , vol.444 , pp. 21-41
    • Deryugina, E.I.1    Quigley, J.P.2
  • 36
    • 0033393771 scopus 로고    scopus 로고
    • Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
    • Eliceiri BP, Paul R, Schwartzberg PL, et al. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell 1999;4:915-924 (Pubitemid 30054898)
    • (1999) Molecular Cell , vol.4 , Issue.6 , pp. 915-924
    • Eliceiri, B.P.1    Paul, R.2    Schwartzberg, P.L.3    Hood, J.D.4    Leng, J.5    Cheresh, D.A.6
  • 37
    • 34047245311 scopus 로고    scopus 로고
    • Chemoresistance of endothelial cells induced by basic fibroblast growth factor depends on Raf-1-mediated inhibition of the proapoptotic kinase, ASK1
    • DOI 10.1158/0008-5472.CAN-06-3648
    • Alavi AS, Acevedo L, Min W, et al. Chemoresistance of endothelial cells induced by basic fibroblast growth factor depends on Raf-1-mediated inhibition of the proapoptotic kinase, ASK1. Cancer Res 2007;6:2766-2772 (Pubitemid 46548965)
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2766-2772
    • Alavi, A.S.1    Acevedo, L.2    Min, W.3    Cheresh, D.A.4
  • 38
    • 33846050010 scopus 로고    scopus 로고
    • Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation
    • Chen RR, Silva EA, Yuen WW, et al. Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharm Res 2007;24(2):258-264
    • (2007) Pharm Res , vol.24 , Issue.2 , pp. 258-264
    • Chen, R.R.1    Silva, E.A.2    Yuen, W.W.3
  • 40
    • 38849202330 scopus 로고    scopus 로고
    • Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
    • Pietras K, Pahler J, Bergers G, et al. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med 2008;5(1):e19
    • (2008) PLoS Med , vol.5 , Issue.1
    • Pietras, K.1    Pahler, J.2    Bergers, G.3
  • 41
  • 43
    • 57649135172 scopus 로고    scopus 로고
    • A role for VEGF as a negative regulator of pericyte function and vessel maturation
    • Greenberg JI, Shields DJ, Barillas SG, et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 2008;456(7223):809-813
    • (2008) Nature , vol.456 , Issue.7223 , pp. 809-813
    • Greenberg, J.I.1    Shields, D.J.2    Barillas, S.G.3
  • 45
    • 0025653869 scopus 로고
    • Leaky tumor vessels: Consequences for tumor stroma generation and for solid tumor therapy
    • Dvorak HF. Leaky tumor vessels: consequences for tumor stroma generation and for solid tumor therapy. Prog Clin Biol Res 1990;345A:317-330
    • (1990) Prog Clin Biol Res , vol.345 A , pp. 317-330
    • Dvorak, H.F.1
  • 46
    • 0036140857 scopus 로고    scopus 로고
    • Analysis of mural cell recruitment to tumor vessels
    • DOI 10.1161/hc0102.101437
    • Abramsson A, Berlin O, Papayan H. Paulin, M. Shani, and C. Betsholtz. Analysis of mural cell recruitment to tumor vessels. Circulation 2002;105(1):112-117 (Pubitemid 34049151)
    • (2002) Circulation , vol.105 , Issue.1 , pp. 112-117
    • Abramsson, A.1    Berlin, O.2    Papayan, H.3    Paulin, D.4    Shani, M.5    Betsholtz, C.6
  • 47
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • DOI 10.1038/ncponc0403, PII N0403
    • Jain RK, Duda DG, Clark JW, et al. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 2006;3:24-40 (Pubitemid 43108832)
    • (2006) Nature Clinical Practice Oncology , vol.3 , Issue.1 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 48
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307(5706):58-62
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 49
    • 1542320497 scopus 로고    scopus 로고
    • Pathology: Cancer cells compress intratumour vessels
    • Padera TP, Stoll BR, Tooredman JB, et al. Pathology: cancer cells compress intratumour vessels. Nature 2004;427(6976):695
    • (2004) Nature , vol.427 , Issue.6976 , pp. 695
    • Padera, T.P.1    Stoll, B.R.2    Tooredman, J.B.3
  • 52
    • 55049136730 scopus 로고    scopus 로고
    • Targeted therapies for metastatic renal cell carcinoma: An overview of toxicity and dosing strategies
    • Hutson TE, Figlin RA, Kuhn JG, et al. Targeted therapies for metastatic renal cell carcinoma: an overview of toxicity and dosing strategies. Oncologist 2008;13:1084-1096
    • (2008) Oncologist , vol.13 , pp. 1084-1096
    • Hutson, T.E.1    Figlin, R.A.2    Kuhn, J.G.3
  • 53
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007;357(26):2666- 2676
    • (2007) N Engl J Med , vol.357 , Issue.26 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 55
    • 3242802116 scopus 로고    scopus 로고
    • "Promiscuous" anticancer drugs that hit multiple targets may thwart resistance
    • Hampton T. "Promiscuous" anticancer drugs that hit multiple targets may thwart resistance. J Am Med Assoc 2004;292:419-420
    • (2004) J Am Med Assoc , vol.292 , pp. 419-420
    • Hampton, T.1
  • 58
    • 57649112725 scopus 로고    scopus 로고
    • Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
    • Stockmann C, Doedens A, Weidemann A, et al. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 2008;456(7223):814-818
    • (2008) Nature , vol.456 , Issue.7223 , pp. 814-818
    • Stockmann, C.1    Doedens, A.2    Weidemann, A.3
  • 60
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • Benjamin LE, Golijanin D, Itin A. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999;103(2):159-165 (Pubitemid 29053133)
    • (1999) Journal of Clinical Investigation , vol.103 , Issue.2 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 64
    • 0035870297 scopus 로고    scopus 로고
    • The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors
    • Sweeney CJ, Miller KD, Sissons SE, et al. The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. Cancer Res 2001;61(8):3369-3372
    • (2001) Cancer Res , vol.61 , Issue.8 , pp. 3369-3372
    • Sweeney, C.J.1    Miller, K.D.2    Sissons, S.E.3
  • 65
    • 7244247062 scopus 로고    scopus 로고
    • Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis
    • DOI 10.1083/jcb.200408130
    • Weis S, Cui J, Barnes L, Cheresh D. Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis. J Cell Biol 2004;167(2):223-229 (Pubitemid 39435066)
    • (2004) Journal of Cell Biology , vol.167 , Issue.2 , pp. 223-229
    • Weis, S.1    Cui, J.2    Barnes, L.3    Cheresh, D.4
  • 66
    • 41149138113 scopus 로고    scopus 로고
    • Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer
    • Jain RK. Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer. Nat Rev Cancer 2008;8(4):309-316
    • (2008) Nat Rev Cancer , vol.8 , Issue.4 , pp. 309-316
    • Jain, R.K.1
  • 67
    • 34447121919 scopus 로고    scopus 로고
    • Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy
    • Dickson PV, Hamner JB, Sims TL, et al. Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy. Clin Cancer Res 2007;13(13):3942-3950
    • (2007) Clin Cancer Res , vol.13 , Issue.13 , pp. 3942-3950
    • Dickson, P.V.1    Hamner, J.B.2    Sims, T.L.3
  • 68
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Pàez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15(3):220-223
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 220-223
    • Pàez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 69
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos JML, Lee CR, Cruz-Munoz W, et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009;15(3):232-239
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 232-239
    • Ebos, J.M.L.1    Lee, C.R.2    Cruz-Munoz, W.3
  • 70
    • 59649117924 scopus 로고    scopus 로고
    • Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
    • Mazzone M, Dettori D, Leite de Oliveira R, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 2009;136(5):839-851
    • (2009) Cell , vol.136 , Issue.5 , pp. 839-851
    • Mazzone, M.1    Dettori, D.2    De Leite Oliveira, R.3
  • 71
    • 70350684353 scopus 로고    scopus 로고
    • Biomarkers of response and resistance to antiangiogenic therapy
    • Jain RK, Duda DG,Willett CG, et al. Biomarkers of response and resistance to antiangiogenic therapy. Nat Clin Pract Oncol 2006;3(12):693-697
    • (2006) Nat Clin Pract Oncol , vol.3 , Issue.12 , pp. 693-697
    • Jain, R.K.1    Duda, D.G.2    Willett, C.G.3


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