A Fast Chromatographic Method for Estimating Lipophilicity and Ionization in Nonpolar Membrane-Like Environment

Molecular Pharmaceutics

Volumn 13, Issue 3, 2016, Pages 1100-1110

  Caron, Giulia ^a   Vallaro, Maura ^a   Ermondi, Giuseppe ^a   Goetz, Gilles H ^b   Abramov, Yuriy A ^b   Philippe, Laurence ^b   Shalaeva, Marina ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b PFIZER INC   (United States)

Author keywords

block relevance analysis; drug molecules; ElogD; intramolecular hydrogen bonds; ionization; lipophilicity descriptor; log Ptol; nonpolar environments; polymeric chromatographic column

Indexed keywords

1 NAPHTHOL; 2 NAPHTHOL; 3 BROMOQUINOLINE; 3 CHLOROPHENOL; 3 NITROPHENOL; 3,5 DICHLOROPHENOL; ACETONITRILE; ACETOPHENONE; ANILINE; ASTEMIZOLE; BIFONAZOLE; BROMAZEPAM; CARBAMAZEPINE; CLOTRIMAZOLE; DEXAMETHASONE; DIAZEPAM; DIETHYLSTILBESTROL; DIVINYLBENZENE; ESTRADIOL; GRISEOFULVIN; HYDROCORTISONE; HYDROCORTISONE ACETATE; LORAZEPAM; LORMETAZEPAM; NAPHTHALENE; NEFAZODONE; NIFEDIPINE; PHENAZONE; POLYSTYRENE; UNCLASSIFIED DRUG; WATER; ACETONITRILE DERIVATIVE; DRUG; POLYMER; TOLUENE;

ARTICLE; COMPUTER MODEL; DIELECTRIC CONSTANT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; IONIZATION; LIPOPHILICITY; PH; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; MEMBRANE; PROCEDURES; SOLUBILITY;

ACETONITRILES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; MEMBRANES; PHARMACEUTICAL PREPARATIONS; POLYMERS; SOLUBILITY; TOLUENE; WATER;

EID: 84960157713     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00910     Document Type: Article

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