Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Liu, Qiang ^a   Zhang, Xin ^a   Hu, Xiaoqing ^a   Dai, Linghui ^a   Fu, Xin ^a   Zhang, Jiying ^a   Ao, Yingfang ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; INTERLEUKIN 1; MICRORNA; MIRN136 MICRORNA, HUMAN; RNA; RNA, CIRCULAR; TUMOR NECROSIS FACTOR;

AGED; ARTICULAR CARTILAGE; CHONDROCYTE; DRUG EFFECTS; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION PROFILING; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; UPREGULATION;

AGED; CARTILAGE, ARTICULAR; CHONDROCYTES; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INTERLEUKIN-1; MALE; MATRIX METALLOPROTEINASE 13; MICRORNAS; MIDDLE AGED; RNA; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84960157256     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep22572     Document Type: Article

References (40)

1. Hayami, T. et al. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone 38, 234-243, doi: 10.1016/j.bone.2005.08.007 (2006).
2. Dieppe, P., Kirwan, J. The localization of osteoarthritis. Br J Rheumatol 33, 201-203 (1994).
3. Goldring, M. B. Update on the biology of the chondrocyte and new approaches to treating cartilage diseases. Best Pract Res Clin Rheumatol 20, 1003-1025, doi: 10.1016/j.berh.2006.06.003 (2006).
4. Kuhn, K., D'Lima, D. D., Hashimoto, S., Lotz, M. Cell death in cartilage. Osteoarthritis Cartilage 12, 1-16 (2004).
5. Goldring, M. B. The role of the chondrocyte in osteoarthritis. Arthritis Rheum 43, 1916-1926, doi: 10.1002/1529-0131(200009)43:9 3.0.CO; 2-I (2000).
6. Lotz, M. Cytokines in cartilage injury and repair. Clin Orthop Relat Res, S108-115 (2001).
7. Loeser, R. F. et al. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum 64, 705-717, doi: 10.1002/art.33388 (2012).
8. Salzman, J., Gawad, C., Wang, P. L., Lacayo, N., Brown, P. O. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. Plos One 7, e30733, doi: 10.1371/journal.pone.0030733 (2012).
9. Conn, S. J. et al. The RNA binding protein quaking regulates formation of circRNAs. Cell 160, 1125-1134, doi: 10.1016/j. cell.2015.02.014 (2015).
10. Memczak, S. et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495, 333-338, doi: 10.1038/nature11928 (2013).
11. Hentze, M. W., Preiss, T. Circular RNAs: splicing's enigma variations. EMBO J 32, 923-925, doi: 10.1038/emboj.2013.53 (2013).
12. Vicens, Q., Westhof, E. Biogenesis of Circular RNAs. Cell 159, 13-14, doi: 10.1016/j.cell.2014.09.005 (2014).
13. Hansen, T. B. et al. Natural RNA circles function as efficient microRNA sponges. Nature 495, 384-388, doi: 10.1038/nature11993 (2013).
14. Burd, C. E. et al. Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet 6, e1001233, doi: 10.1371/journal.pgen.1001233 (2010).
15. Chen, Y. T. et al. Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse. Proc Natl Acad Sci USA 87, 3077-3081 (1990).
16. You, X. et al. Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci 18, 603-610, doi: 10.1038/nn.3975 (2015).
17. Goldring, M. B., Birkhead, J., Sandell, L. J., Kimura, T., Krane, S. M. Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. J Clin Invest 82, 2026-2037, doi: 10.1172/JCI113823 (1988).
18. Liu, Q. et al. Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis. Arthritis Rheumatol 66, 969-978, doi: 10.1002/art.38309 (2014).
19. Zhang, Y. et al. Circular intronic long noncoding RNAs. Mol Cell 51, 792-806, doi: 10.1016/j.molcel.2013.08.017 (2013).
20. Jeck, W. R. et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA 19, 141-157, doi: 10.1261/rna.035667.112 (2013).
21. Li, P. et al. Using circular RNA as a novel type of biomarker in the screening of gastric cancer. Clin Chim Acta 444, 132-136, doi: 10.1016/j.cca.2015.02.018 (2015).
22. Peng, L., Yuan, X. Q., Li, G. C. The emerging landscape of circular RNA ciRS-7 in cancer (Review). Oncol Rep 33, 2669-2674, doi: 10.3892/or.2015.3904 (2015).
23. Zhang, Z. et al. Expression of microRNAs during chondrogenesis of human adipose-derived stem cells. Osteoarthritis Cartilage 20, 1638-1646, doi: 10.1016/j.joca.2012.08.024 (2012).
24. Zhang, Y. et al. A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. Proc Natl Acad Sci USA 108, 9863-9868, doi: 10.1073/pnas.1018493108 (2011).
25. Zhang, Y. et al. Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2. J Biol Chem 287, 21926-21935, doi: 10.1074/jbc.M112.340398 (2012).
26. Bauge, C., Girard, N., Lhuissier, E., Bazille, C., Boumediene, K. Regulation and Role of TGFbeta Signaling Pathway in Aging and Osteoarthritis Joints. Aging Dis 5, 394-405, doi: 10.14336/AD.2014.0500394 (2014).
27. Zhang, X. et al. Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Bone 34, 809-817, doi: 10.1016/j.bone.2003.12.026 (2004).
28. Goumans, M. J. et al. Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J 21, 1743-1753, doi: 10.1093/emboj/21.7.1743 (2002).
29. van der Kraan, P. M., Blaney Davidson, E. N., Blom, A., van den Berg, W. B. TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads. Osteoarthritis Cartilage 17, 1539-1545, doi: 10.1016/j.joca.2009.06.008 (2009).
30. Blaney Davidson, E. N. et al. Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. J Immunol 182, 7937-7945, doi: 10.4049/jimmunol.0803991 (2009).
31. Fan, Z., Soder, S., Oehler, S., Fundel, K., Aigner, T. Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage. Am J Pathol 171, 938-946, doi: 10.2353/ajpath.2007.061083 (2007).
32. Loeser, R. F., Forsyth, C. B., Samarel, A. M., Im, H. J. Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway. J Biol Chem 278, 24577-24585, doi: 10.1074/jbc.M304530200 (2003).
33. Lam, J. K., Chow, M. Y., Zhang, Y., Leung, S. W. siRNA Versus miRNA as Therapeutics for Gene Silencing. Mol Ther Nucleic Acids 4, e252, doi: 10.1038/mtna.2015.23 (2015).
34. Mankin, H. J., Dorfman, H., Lippiello, L., Zarins, A. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 53, 523-537 (1971).
35. Miyaki, S. et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum 60, 2723-2730, doi: 10.1002/art.24745 (2009).
36. Pujana, M. A. et al. Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet 39, 1338-1349, doi: 10.1038/ng.2007.2 (2007).
37. Prieto, C., Risueno, A., Fontanillo, C., De las Rivas, J. Human gene coexpression landscape: confident network derived from tissue transcriptomic profiles. PLoS One 3, e3911, doi: 10.1371/journal.pone.0003911 (2008).
38. Barabasi, A. L., Oltvai, Z. N. Network biology: understanding the cell's functional organization. Nat Rev Genet 5, 101-113, doi: 10.1038/nrg1272 (2004).
39. Enright, A. J. et al. MicroRNA targets in Drosophila. Genome Biol 5, R1, doi: 10.1186/gb-2003-5-1-r1 (2003).
40. Pasquinelli, A. E. MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet 13, 271-282, doi: 10.1038/nrg3162 (2012).