De Novo Design of Skin-Penetrating Peptides for Enhanced Transdermal Delivery of Peptide Drugs

Advanced Healthcare Materials

Volumn 5, Issue 5, 2016, Pages 602-609

  Menegatti, Stefano ^a   Zakrewsky, Michael ^b   Kumar, Sunny ^c   De Oliveira, Joshua Sanchez ^b   Muraski, John A ^d   Mitragotri, Samir ^b  

^a North Carolina State University   (United States)

^b University of California   (United States)

^c Biomedical Group   (United States)

^d Convoy Therapeutics ^*  (United States)

Author keywords

Cyclosporine A; De novo peptide design; Keratin; Skin penetrating peptides; Transdermal delivery

Indexed keywords

AFFINITY CHROMATOGRAPHY; CONTROLLED DRUG DELIVERY; DIGITAL LIBRARIES; DRUG PRODUCTS; KERATIN; LIBRARIES; MASS SPECTROMETRY; SULFUR COMPOUNDS; SURFACE PLASMON RESONANCE; TARGETED DRUG DELIVERY;

COMPUTATIONAL PROCESS; CYCLIC PEPTIDES; CYCLOSPORINE A; DE NOVO PEPTIDE DESIGN; PEPTIDE LIBRARY; TRANSDERMAL DELIVERY; TRANSDERMAL PERMEATION; VIRTUAL LIBRARIES;

PEPTIDES;

CYCLOSPORIN A; DISULFIDE; KERATIN; PEPTIDE DERIVATIVE; SKIN PENETRATING PEPTIDE; UNCLASSIFIED DRUG; CYCLOSPORIN; DRUG; PEPTIDE; PEPTIDE LIBRARY;

ADULT; AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; KERATINOCYTE; MASS SPECTROMETRY; NONHUMAN; PIG; PRIORITY JOURNAL; SCREENING; SKIN PENETRATION; TRANSDERMAL DRUG DELIVERY SYSTEM; AMINO ACID SEQUENCE; CELL SURVIVAL; CHEMISTRY; COMPUTER SIMULATION; CUTANEOUS DRUG ADMINISTRATION; CYTOLOGY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG EFFECTS; EPIDERMIS; METABOLISM; PEPTIDE LIBRARY; PROCEDURES; SKIN; SKIN ABSORPTION; THERMODYNAMICS;

ADMINISTRATION, CUTANEOUS; ADULT; AMINO ACID SEQUENCE; CELL SURVIVAL; COMPUTER SIMULATION; CYCLOSPORINE; DRUG DELIVERY SYSTEMS; DRUG DESIGN; EPIDERMIS; HUMANS; KERATINOCYTES; KERATINS; MASS SPECTROMETRY; PEPTIDE LIBRARY; PEPTIDES; PHARMACEUTICAL PREPARATIONS; SKIN; SKIN ABSORPTION; THERMODYNAMICS;

EID: 84960131905     PISSN: 21922640     EISSN: 21922659     Source Type: Journal    
DOI: 10.1002/adhm.201500634     Document Type: Article

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