2,3',4,4',5-pentachlorobiphenyl induces inflammatory responses in the thyroid through JNK and Aryl hydrocarbon receptor-mediated pathway

Toxicological Sciences

Volumn 149, Issue 2, 2016, Pages 300-311

  Xu, Bojin ^a   Yang, Hui ^a   Sun, Minne ^a   Chen, Huanhuan ^a   Jiang, Lin ^a   Zheng, Xuqin ^a   Ding, Guoxian ^a   Liu, Yun ^a   Sheng, Yunlu ^a   Cui, Dai ^a   Duan, Yu ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

AhR; Inflammatory mediators; JNK pathway; Polychlorinated biphenyl 118; sodium iodide symporter; Thyroid disturbance

Indexed keywords

2,3',4,4',5 PENTACHLOROBIPHENYL; ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; POLYCHLORINATED BIPHENYL DERIVATIVE; SMALL INTERFERING RNA; SODIUM IODIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 2,3',4,4',5-PENTACHLOROBIPHENYL; POLYCHLORINATED BIPHENYL; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DOSE TIME EFFECT RELATION; DOWN REGULATION; EXPOSURE VARIABLE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; THYROID INFLAMMATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; THYROID GLAND; WISTAR RAT;

ANIMALS; CELL SURVIVAL; CYTOCHROME P-450 CYP1A1; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; MALE; MAP KINASE SIGNALING SYSTEM; POLYCHLORINATED BIPHENYLS; RATS; RATS, WISTAR; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; THYROID GLAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84960131833     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv235     Document Type: Article

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