Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis

Aging Cell

Volumn 15, Issue 2, 2016, Pages 349-360

  Al Chami, E ^a   Tormo, A ^a   Pasquin, S ^a   Kanjarawi, R ^a   Ziouani, S ^b   Rafei, M ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Interleukin 21; MiR 181a; Signaling; T cells; Thymic involution; Tumor vaccine

Indexed keywords

DENDRITIC CELL VACCINE; DOPACHROME TAUTOMERASE; DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE 5; DUAL SPECIFICITY PHOSPHATASE 6; MICRORNA; MICRORNA 181A; PROTEIN TYROSINE PHOSPHATASE SHP 2; RECOMBINANT INTERLEUKIN 21; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; INTERLEUKIN 21; INTERLEUKIN DERIVATIVE; LYMPHOCYTE ANTIGEN RECEPTOR;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNIZATION; CANCER INHIBITION; CANCER SURVIVAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MALE; MELANOMA B16; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL EXPANSION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMIC EPITHELIAL CELL; THYMOCYTE; THYMOPOIESIS; THYMUS; TUMOR VOLUME; ANIMAL; C57BL MOUSE; DRUG EFFECTS; IMMUNOLOGY; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE; TUMOR CELL LINE;

AGING; ANIMALS; CELL LINE, TUMOR; FEMALE; INTERLEUKINS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; THYMOCYTES; THYMUS GLAND;

EID: 84960117830     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12440     Document Type: Article

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