SIRT1 inhibits differentiation of monocytes to macrophages: amelioration of synovial inflammation in rheumatoid arthritis

Journal of Molecular Medicine

Volumn 94, Issue 8, 2016, Pages 921-931

  Park, So Youn ^a   Lee, Sung Won ^b   Kim, Hye Young ^a   Lee, Sang Yeob ^b   Lee, Won Suk ^c   Hong, Ki Whan ^a   Kim, Chi Dae ^a,c  

^a Pusan National University   (South Korea)

^b Dong A University   (South Korea)

^c Pusan National University School of Medicine   (South Korea)

Author keywords

Inflammation; Monocyte to macrophage differentiation; Rheumatoid arthritis; SIRT1

Indexed keywords

ACTIN; CD11B ANTIGEN; CD14 ANTIGEN; CD36 ANTIGEN; ETANERCEPT; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; METHOTREXATE; PHORBOL 13 ACETATE 12 MYRISTATE; PREDNISONE; RESVERATROL; SIRTINOL; SIRTUIN 1; TRANSCRIPTION FACTOR PU 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ONCOPROTEIN; PROTO-ONCOGENE PROTEIN SPI-1; SIRT1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ACETYLATION; ADULT; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; BONE MARROW DERIVED MONOCYTE; CELL ADHESION; CELL DIFFERENTIATION; CELL STIMULATION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; MACROPHAGE; MALE; MIDDLE AGED; MONOCYTE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; SYNOVITIS; TRANSCRIPTION INITIATION; ANIMAL; C57BL MOUSE; CELL CULTURE; ENZYMOLOGY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING; SECRETION (PROCESS); TRANSGENIC MOUSE;

ANIMALS; ARTHRITIS, RHEUMATOID; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; FEMALE; HUMANS; MACROPHAGES; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDDLE AGED; MONOCYTES; NF-KAPPA B; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS; SIRTUIN 1; TRANS-ACTIVATORS;

EID: 84960103001     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-016-1402-7     Document Type: Article

References (39)

1. Sweeney SE, Firestein GS (2004) Rheumatoid arthritis: regulation of synovial inflammation. Int J Biochem Cell Biol 36:372–378
2. Goldring SR, Gravallese EM (2000) Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications. Arthritis Res 2:33–37
3. Mulherin D, Fitzgerald O, Bresnihan B (1996) Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum 39:115–124
4. Kinne RW, Stuhlmüller B, Burmester GR (2007) Cells of the synovium in rheumatoid arthritis. Macrophages. Arthritis Res Ther 9:224
5. Haigis MC, Sinclair DA (2010) Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5:253–295
6. Yoshizaki T, Schenk S, Imamura T, Babendure JL, Sonoda N, Bae EJ, Oh DY, Lu M, Milne JC, Westphal C et al (2010) SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am J Physiol Endocrinol Metab 298:E419–E428
7. Yang H, Zhang W, Pan H, Feldser HG, Lainez E, Miller C, Leung S, Zhong Z, Zhao H, Sweitzer S et al (2012) SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity. PLoS One 7, e46364
8. Moon MH, Jeong JK, Lee YJ, Seol JW, Jackson CJ, Park SY (2013) SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes. Osteoarthr Cartil 21:470–480
9. Hah YS, Cheon YH, Lim HS, Cho HY, Park BH, Ka SO, Lee YR, Jeong DW, Kim HO, Han MK et al (2014) Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-κB activation. PLoS One 9, e87733
10. Yang X, Karsenty G (2002) Transcription factors in bone: developmental and pathological aspects. Trends Mol Med 8:340–345
11. Kwon OH, Lee CK, Lee YI, Paik SG, Lee HJ (2005) The hematopoietic transcription factor PU.1 regulates RANK gene expression in myeloid progenitors. Biochem Biophys Res Commun 335:437–464
12. Park SY, Lee SW, Baek SH, Lee CW, Lee WS, Rhim BY, Hong KW, Kim CD (2013) Suppression of PU.1-linked TLR4 expression by cilostazol with decrease of cytokine production in macrophages from patients with rheumatoid arthritis. Br J Pharmacol 168:1401–1411
13. Schwende H, Fitzke E, Ambs P, Dieter P (1996) Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25-dihydroxyvitamin D3. J Leukoc Biol 59:555–561
14. Gross SA, Zheng JH, Le AT, Kerzic PJ, Irons RD (2006) PU.1 phosphorylation correlates with hydroquinone-induced alterations in myeloid differentiation and cytokine-dependent clonogenic response in human CD34(+) hematopoietic progenitor cells. Cell Biol Toxicol 22:229–241
15. Fujii I, Shingu M, Nobunaga M (1990) Monocyte activation in early onset rheumatoid arthritis. Ann Rheum Dis 49:497–503
16. Herranz D, Muñoz-Martin M, Cañamero M, Mulero F, Martinez-Pastor B, Fernandez-Capetillo O, Serrano M (2010) Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun 12:1–3
17. Winnik S, Stein S, Matter CM (2012) SIRT1—an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis. Curr Vasc Pharmacol 10:693–696
18. Jimenez-Boj E, Redlich K, Türk B, Hanslik-Schnabel B, Wanivenhaus A, Chott A, Smolen JS, Schett G (2005) Interaction between synovial inflammatory tissue and bone marrow in rheumatoid arthritis. J Immunol 175:2579–2588
19. Baek YS, Haas S, Hackstein H, Bein G, Hernandez-Santana M, Lehrach H, Sauer S, Seitz H (2009) Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells. BMC Immunol 2:10–18
20. Huh HY, Pearce SF, Yesner LM, Schindler JL, Silverstein RL (1996) Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation. Blood 87:2020–2028
21. Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J (2007) SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6:759–767
22. Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S (2011) SirT1 regulates adipose tissue inflammation. Diabetes 60:3235–3245
23. Nimmagadda VK, Bever CT, Vattikunta NR, Talat S, Ahmad V, Nagalla NK, Trisler D, Judge SI, Royal W 3rd, Chandrasekaran K et al (2013) Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets. J Immunol 190:4595–4607
24. Kinne RW, Bräuer R, Stuhlmüller B, Palombo-Kinne E, Burmester GR (2000) Macrophages in rheumatoid arthritis. Arthritis Res 2:189–202
25. Gilston V, Jones HW, Soo CC, Coumbe A, Blades S, Kaltschmidt C, Baeuerle PA, Morris CJ, Blake DR, Winyard PG (1997) NF-kappa B activation in human knee-joint synovial tissue during the early stage of joint inflammation. Biochem Soc Trans 25:518S
26. Makarov SS (2001) NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction. Arthritis Res 3:200–206
27. Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW (2004) Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23:2369–2380
28. Kim HY, Park SY, Lee SW, Lee HR, Lee WS, Rhim BY, Hong KW, Kim CD (2014) Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis. PLoS One 15, e104743
29. Huang Z, Wang C, Wei L, Wang J, Fan Y, Wang L, Wang Y, Chen T (2008) Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells. Biochem Biophys Res Commun 374:517–521
30. Zong Y, Sun L, Liu B, Deng YS, Zhan D, Chen YL, He Y, Liu J, Zhang ZJ, Sun J et al (2012) Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells. PLoS One 7, e44107
31. Valledor AF, Borràs FE, Cullell-Young M, Celada A (1998) Transcription factors that regulate monocyte/macrophage differentiation. J Leukoc Biol 63:405–445
32. DeKoter RP, Walsh JC, Singh H (1998) PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J 17:4456–4468
33. Pahl HL, Scheibe RJ, Zhang DE, Chen HM, Galson DL, Maki RA, Tenen DG (1993) The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter. J Biol Chem 268:5014–5020
34. Zhang DE, Hetherigton CJ, Tan S, Dziennis SE, Gonzalez DA, Chen HM, Tenen DG (1994) Sp1 is a critical factor for the monocytic specific expression of human CD14. J Biol Chem 269:11425–11434
35. Lan F, Cacicedo JM, Ruderman N, Ido Y (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem 283:27628–27635
36. Zhang Y, Qiu J, Wang X, Zhang Y, Xia M (2011) AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300. Arterioscler Thromb Vasc Biol 31:2897–2908
37. Lee HR, Shin HK, Park SY, Kim HY, Lee WS, Rhim BY, Hong KW, Kim CD (2014) Attenuation of β-amyloid-induced tauopathy via activation of CK2α/SIRT1: targeting for cilostazol. J Neurosci Res 92:206–217
38. Park SY, Lee SW, Kim HY, Lee SY, Lee WS, Hong KW, Kim CD (2015) Suppression of RANKL-induced osteoclast differentiation by cilostazol via SIRT1-induced RANK inhibition. Biochim Biophys Acta 1852:2137–2144
39. Lloberas J, Soler C, Celada A (1999) Mechanism of I-Abeta gene expression. Immunol Today 20:184–189