메뉴 건너뛰기




Volumn 37, Issue 8, 2016, Pages 11365-11374

Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway

Author keywords

Gastric cancer; Invasion; Naringenin; Proliferation; Signal transduction pathway

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CYCLINE; GELATINASE A; GELATINASE B; NARINGENIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SURVIVIN; ANTINEOPLASTIC AGENT; FLAVANONE DERIVATIVE;

EID: 84960088814     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-016-5013-2     Document Type: Article
Times cited : (101)

References (37)
  • 2
    • 84869492886 scopus 로고    scopus 로고
    • Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions
    • PID: 23079588
    • Soerjomataram I, Lortet-Tieulent J, Parkin DM, Ferlay J, Mathers C, et al. Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions. Lancet. 2012;380:1840–50.
    • (2012) Lancet , vol.380 , pp. 1840-1850
    • Soerjomataram, I.1    Lortet-Tieulent, J.2    Parkin, D.M.3    Ferlay, J.4    Mathers, C.5
  • 3
    • 77955058763 scopus 로고    scopus 로고
    • The role of traditional Chinese herbal medicines in cancer therapy—from TCM theory to mechanistic insights
    • COI: 1:CAS:528:DC%2BC3cXhtFSks73F, PID: 20635308
    • Hsiao WL, Liu L. The role of traditional Chinese herbal medicines in cancer therapy—from TCM theory to mechanistic insights. Planta Med. 2010;76:1118–31.
    • (2010) Planta Med , vol.76 , pp. 1118-1131
    • Hsiao, W.L.1    Liu, L.2
  • 4
    • 84866469084 scopus 로고    scopus 로고
    • Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents
    • PID: 22524801
    • Meiyanto E, Hermawan A, Anindyajati. Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents. Asian Pac J Cancer Prev. 2012;13:427–36.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 427-436
    • Meiyanto, E.1    Hermawan, A.2    Anindyajati3
  • 5
    • 45549094966 scopus 로고    scopus 로고
    • Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole-blood models
    • COI: 1:CAS:528:DC%2BD1cXpsVOhu7o%3D, PID: 18503517
    • Bodet C, La VD, Epifano F, Grenier D. Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole-blood models. J Periodontal Res. 2008;43:400–7.
    • (2008) J Periodontal Res , vol.43 , pp. 400-407
    • Bodet, C.1    La, V.D.2    Epifano, F.3    Grenier, D.4
  • 6
    • 0034813893 scopus 로고    scopus 로고
    • Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits
    • COI: 1:CAS:528:DC%2BD3MXktFKjs7g%3D, PID: 11396955
    • Lee CH, Jeong TS, Choi YK, Hyun BH, Oh GT, et al. Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits. Biochem Biophys Res Commun. 2001;284:681–8.
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 681-688
    • Lee, C.H.1    Jeong, T.S.2    Choi, Y.K.3    Hyun, B.H.4    Oh, G.T.5
  • 7
    • 84862559946 scopus 로고    scopus 로고
    • Protective effect of naringenin against lead-induced oxidative stress in rats
    • COI: 1:CAS:528:DC%2BC38XlvFWmurw%3D, PID: 22109809
    • Wang J, Yang Z, Lin L, Zhao Z, Liu Z, et al. Protective effect of naringenin against lead-induced oxidative stress in rats. Biol Trace Elem Res. 2012;146:354–9.
    • (2012) Biol Trace Elem Res , vol.146 , pp. 354-359
    • Wang, J.1    Yang, Z.2    Lin, L.3    Zhao, Z.4    Liu, Z.5
  • 8
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
    • COI: 1:CAS:528:DC%2BD3sXktFOnsbg%3D, PID: 12778135
    • Fidler IJ. The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer. 2003;3:453–8.
    • (2003) Nat Rev Cancer , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 9
    • 84908211500 scopus 로고    scopus 로고
    • Myricetin and naringenin inhibit human squamous cell carcinoma proliferation and migration in vitro
    • COI: 1:CAS:528:DC%2BC2cXhs12nsb3J, PID: 25256786
    • Maggioni D, Nicolini G, Rigolio R, Biffi L, Pignataro L, et al. Myricetin and naringenin inhibit human squamous cell carcinoma proliferation and migration in vitro. Nutr Cancer. 2014;66:1257–67.
    • (2014) Nutr Cancer , vol.66 , pp. 1257-1267
    • Maggioni, D.1    Nicolini, G.2    Rigolio, R.3    Biffi, L.4    Pignataro, L.5
  • 10
    • 84922023876 scopus 로고    scopus 로고
    • Naringenin suppresses K562 human leukemia cell proliferation and ameliorates adriamycin-induced oxidative damage in polymorphonuclear leukocytes
    • COI: 1:CAS:528:DC%2BC2MXmt1GktLs%3D, PID: 25667616
    • Li RF, Feng YQ, Chen JH, Ge LT, Xiao SY, et al. Naringenin suppresses K562 human leukemia cell proliferation and ameliorates adriamycin-induced oxidative damage in polymorphonuclear leukocytes. Exp Ther Med. 2015;9:697–706.
    • (2015) Exp Ther Med , vol.9 , pp. 697-706
    • Li, R.F.1    Feng, Y.Q.2    Chen, J.H.3    Ge, L.T.4    Xiao, S.Y.5
  • 11
    • 84905502744 scopus 로고    scopus 로고
    • Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP-2
    • COI: 1:CAS:528:DC%2BC2cXhsVynsLjJ, PID: 25017119
    • Liao AC, Kuo CC, Huang YC, Yeh CW, Hseu YC, et al. Naringenin inhibits migration of bladder cancer cells through downregulation of AKT and MMP-2. Mol Med Rep. 2014;10:1531–6.
    • (2014) Mol Med Rep , vol.10 , pp. 1531-1536
    • Liao, A.C.1    Kuo, C.C.2    Huang, Y.C.3    Yeh, C.W.4    Hseu, Y.C.5
  • 12
    • 84927727711 scopus 로고    scopus 로고
    • Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells
    • COI: 1:CAS:528:DC%2BC2MXmsFylsb0%3D, PID: 25866363
    • Yen HR, Liu CJ, Yeh CC. Naringenin suppresses TPA-induced tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015;235:1–9.
    • (2015) Chem Biol Interact , vol.235 , pp. 1-9
    • Yen, H.R.1    Liu, C.J.2    Yeh, C.C.3
  • 13
    • 80053082680 scopus 로고    scopus 로고
    • Naringenin reduces lung metastasis in a breast cancer resection model
    • COI: 1:CAS:528:DC%2BC3MXovFehsLg%3D, PID: 21748601
    • Qin L, Jin L, Lu L, Lu X, Zhang C, et al. Naringenin reduces lung metastasis in a breast cancer resection model. Protein Cell. 2011;2:507–16.
    • (2011) Protein Cell , vol.2 , pp. 507-516
    • Qin, L.1    Jin, L.2    Lu, L.3    Lu, X.4    Zhang, C.5
  • 14
    • 84862309686 scopus 로고    scopus 로고
    • Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities
    • COI: 1:CAS:528:DC%2BC38XntFajs7k%3D, PID: 22314287
    • Weng CJ, Yen GC. Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. Cancer Metastasis Rev. 2012;31:323–51.
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 323-351
    • Weng, C.J.1    Yen, G.C.2
  • 15
    • 84920506588 scopus 로고    scopus 로고
    • Chemopreventive and therapeutic potential of “naringenin,” a flavanone present in citrus fruits
    • COI: 1:CAS:528:DC%2BC2cXitFOgtb3I, PID: 25514618
    • Mir IA, Tiku AB. Chemopreventive and therapeutic potential of “naringenin,” a flavanone present in citrus fruits. Nutr Cancer. 2015;67:27–42.
    • (2015) Nutr Cancer , vol.67 , pp. 27-42
    • Mir, I.A.1    Tiku, A.B.2
  • 16
    • 84884674161 scopus 로고    scopus 로고
    • Screening of chemopreventive effect of naringenin-loaded nanoparticles in DMBA-induced hamster buccal pouch carcinogenesis by FT-IR spectroscopy
    • COI: 1:CAS:528:DC%2BC3sXptVyqsLg%3D, PID: 23749199
    • Krishnakumar N, Sulfikkarali NK, Manoharan S, Nirmal RM. Screening of chemopreventive effect of naringenin-loaded nanoparticles in DMBA-induced hamster buccal pouch carcinogenesis by FT-IR spectroscopy. Mol Cell Biochem. 2013;382:27–36.
    • (2013) Mol Cell Biochem , vol.382 , pp. 27-36
    • Krishnakumar, N.1    Sulfikkarali, N.K.2    Manoharan, S.3    Nirmal, R.M.4
  • 17
    • 84880114929 scopus 로고    scopus 로고
    • Chemopreventive efficacy of naringenin-loaded nanoparticles in 7,12-dimethylbenz(A)anthracene induced experimental oral carcinogenesis
    • COI: 1:CAS:528:DC%2BC3sXmt1CitL8%3D, PID: 23233294
    • Sulfikkarali N, Krishnakumar N, Manoharan S, Nirmal RM. Chemopreventive efficacy of naringenin-loaded nanoparticles in 7,12-dimethylbenz(A)anthracene induced experimental oral carcinogenesis. Pathol Oncol Res. 2013;19:287–96.
    • (2013) Pathol Oncol Res , vol.19 , pp. 287-296
    • Sulfikkarali, N.1    Krishnakumar, N.2    Manoharan, S.3    Nirmal, R.M.4
  • 18
    • 84874001241 scopus 로고    scopus 로고
    • Chinese patients with gastric cancer need targeted adjuvant chemotherapy schemes
    • PID: 23244147
    • Shi WT, Wei L, Xiang J, Su K, Ding Q, et al. Chinese patients with gastric cancer need targeted adjuvant chemotherapy schemes. Asian Pac J Cancer Prev. 2012;13:5263–72.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 5263-5272
    • Shi, W.T.1    Wei, L.2    Xiang, J.3    Su, K.4    Ding, Q.5
  • 19
    • 0036488589 scopus 로고    scopus 로고
    • Role of integrins in cell invasion and migration
    • PID: 12635172
    • Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer. 2002;2:91–100.
    • (2002) Nat Rev Cancer , vol.2 , pp. 91-100
    • Hood, J.D.1    Cheresh, D.A.2
  • 20
    • 52049111209 scopus 로고    scopus 로고
    • Integrins in breast cancer dormancy
    • COI: 1:CAS:528:DC%2BD1cXht1CjsbzM, PID: 18834411
    • Pontier SM, Muller WJ. Integrins in breast cancer dormancy. APMIS. 2008;116:677–84.
    • (2008) APMIS , vol.116 , pp. 677-684
    • Pontier, S.M.1    Muller, W.J.2
  • 21
    • 84892758917 scopus 로고    scopus 로고
    • 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1
    • COI: 1:CAS:528:DC%2BC2cXislKjtw%3D%3D, PID: 24220240
    • Li H, Zhu F, Chen H, Cheng KW, Zykova T, et al. 6-C-(E-phenylethenyl)-naringenin suppresses colorectal cancer growth by inhibiting cyclooxygenase-1. Cancer Res. 2014;74:243–52.
    • (2014) Cancer Res , vol.74 , pp. 243-252
    • Li, H.1    Zhu, F.2    Chen, H.3    Cheng, K.W.4    Zykova, T.5
  • 22
    • 23944440907 scopus 로고    scopus 로고
    • Negative regulation of beta-catenin/Tcf signaling by naringenin in AGS gastric cancer cell
    • COI: 1:CAS:528:DC%2BD2MXpsVCgurg%3D, PID: 16102728
    • Lee JH, Park CH, Jung KC, Rhee HS, Yang CH. Negative regulation of beta-catenin/Tcf signaling by naringenin in AGS gastric cancer cell. Biochem Biophys Res Commun. 2005;335:771–6.
    • (2005) Biochem Biophys Res Commun , vol.335 , pp. 771-776
    • Lee, J.H.1    Park, C.H.2    Jung, K.C.3    Rhee, H.S.4    Yang, C.H.5
  • 23
    • 38349087272 scopus 로고    scopus 로고
    • Naringenin reduces tumor size and weight lost in N-methyl-N′-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats
    • COI: 1:CAS:528:DC%2BD1cXhtV2hu7k%3D, PID: 19083396
    • Ekambaram G, Rajendran P, Magesh V, Sakthisekaran D. Naringenin reduces tumor size and weight lost in N-methyl-N′-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. Nutr Res. 2008;28:106–12.
    • (2008) Nutr Res , vol.28 , pp. 106-112
    • Ekambaram, G.1    Rajendran, P.2    Magesh, V.3    Sakthisekaran, D.4
  • 24
    • 52649115464 scopus 로고    scopus 로고
    • Impact of naringenin on glycoprotein levels in N-methyl-N′-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats
    • COI: 1:CAS:528:DC%2BD1cXhtVGktLzN, PID: 18766002
    • Ekambaram G, Rajendran P, Devaraja R, Muthuvel R, Sakthisekaran D. Impact of naringenin on glycoprotein levels in N-methyl-N′-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats. Anti Cancer Drugs. 2008;19:885–90.
    • (2008) Anti Cancer Drugs , vol.19 , pp. 885-890
    • Ekambaram, G.1    Rajendran, P.2    Devaraja, R.3    Muthuvel, R.4    Sakthisekaran, D.5
  • 25
    • 84859742418 scopus 로고    scopus 로고
    • Sorghum phenolics demonstrate estrogenic action and induce apoptosis in nonmalignant colonocytes
    • COI: 1:CAS:528:DC%2BC38XlsFemtbY%3D, PID: 22369068
    • Yang L, Allred KF, Geera B, Allred CD, Awika JM. Sorghum phenolics demonstrate estrogenic action and induce apoptosis in nonmalignant colonocytes. Nutr Cancer. 2012;64:419–27.
    • (2012) Nutr Cancer , vol.64 , pp. 419-427
    • Yang, L.1    Allred, K.F.2    Geera, B.3    Allred, C.D.4    Awika, J.M.5
  • 26
    • 84864228669 scopus 로고    scopus 로고
    • The naringenin-induced proapoptotic effect in breast cancer cell lines holds out against a high bisphenol a background
    • COI: 1:CAS:528:DC%2BC38XotlCrtLk%3D, PID: 22692793
    • Bulzomi P, Bolli A, Galluzzo P, Acconcia F, Ascenzi P, et al. The naringenin-induced proapoptotic effect in breast cancer cell lines holds out against a high bisphenol a background. IUBMB Life. 2012;64:690–6.
    • (2012) IUBMB Life , vol.64 , pp. 690-696
    • Bulzomi, P.1    Bolli, A.2    Galluzzo, P.3    Acconcia, F.4    Ascenzi, P.5
  • 27
    • 0036019933 scopus 로고    scopus 로고
    • Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice
    • COI: 1:CAS:528:DC%2BD38XotlWltrk%3D, PID: 12215209
    • Matsuzawa A, Nishitoh H, Tobiume K, Takeda K, Ichijo H. Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice. Antioxid Redox Signal. 2002;4:415–25.
    • (2002) Antioxid Redox Signal , vol.4 , pp. 415-425
    • Matsuzawa, A.1    Nishitoh, H.2    Tobiume, K.3    Takeda, K.4    Ichijo, H.5
  • 28
    • 84902826904 scopus 로고    scopus 로고
    • Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity
    • COI: 1:CAS:528:DC%2BC2cXotV2ks7w%3D, PID: 24622325
    • Rooswinkel RW, van de Kooij B, de Vries E, Paauwe M, Braster R, et al. Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity. Blood. 2014;123:2806–15.
    • (2014) Blood , vol.123 , pp. 2806-2815
    • Rooswinkel, R.W.1    van de Kooij, B.2    de Vries, E.3    Paauwe, M.4    Braster, R.5
  • 29
    • 84865323320 scopus 로고    scopus 로고
    • Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC38XhslCqu73E, PID: 22928777
    • Kotsafti A, Farinati F, Cardin R, Cillo U, Nitti D, et al. Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma. BMC Gastroenterol. 2012;12:118.
    • (2012) BMC Gastroenterol , vol.12 , pp. 118
    • Kotsafti, A.1    Farinati, F.2    Cardin, R.3    Cillo, U.4    Nitti, D.5
  • 30
    • 12344252751 scopus 로고    scopus 로고
    • Mechanisms of cancer cell invasion
    • COI: 1:CAS:528:DC%2BD2MXmvFertw%3D%3D, PID: 15661538
    • Sahai E. Mechanisms of cancer cell invasion. Curr Opin Genet Dev. 2005;15:87–96.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 87-96
    • Sahai, E.1
  • 32
    • 84930761038 scopus 로고    scopus 로고
    • New strategies for targeting matrix metalloproteinases
    • PID: 25595836
    • Fields GB. New strategies for targeting matrix metalloproteinases. Matrix Biol. 2015;44–46:239–46.
    • (2015) Matrix Biol , vol.44-46 , pp. 239-246
    • Fields, G.B.1
  • 33
    • 77950845621 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis
    • COI: 1:CAS:528:DC%2BC3cXkt1CrsLs%3D, PID: 20333791
    • Sampieri CL, de la Peña S, Ochoa-Lara M, Zenteno-Cuevas R, León-Córdoba K. Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis. World J Gastroenterol. 2010;16:1500–5.
    • (2010) World J Gastroenterol , vol.16 , pp. 1500-1505
    • Sampieri, C.L.1    de la Peña, S.2    Ochoa-Lara, M.3    Zenteno-Cuevas, R.4    León-Córdoba, K.5
  • 34
    • 84913554338 scopus 로고    scopus 로고
    • Naringenin reduces cholesterol-induced hepatic inflammation in rats by modulating matrix metalloproteinases-2, 9 via inhibition of nuclear factor κB pathway
    • COI: 1:CAS:528:DC%2BC2cXhvFeju7nE, PID: 25446569
    • Chtourou Y, Fetoui H, Jemai R, Ben Slima A, Makni M, et al. Naringenin reduces cholesterol-induced hepatic inflammation in rats by modulating matrix metalloproteinases-2, 9 via inhibition of nuclear factor κB pathway. Eur J Pharmacol. 2015;746:96–105.
    • (2015) Eur J Pharmacol , vol.746 , pp. 96-105
    • Chtourou, Y.1    Fetoui, H.2    Jemai, R.3    Ben Slima, A.4    Makni, M.5
  • 35
    • 84919488659 scopus 로고    scopus 로고
    • Effect of DAPK1 gene on proliferation, migration, and invasion of carcinoma of pancreas BxPC-3 cell line
    • PID: 25550789
    • Qin Y, Ye GX, Wu CJ, Wang S, Pan DB, et al. Effect of DAPK1 gene on proliferation, migration, and invasion of carcinoma of pancreas BxPC-3 cell line. Int J Clin Exp Pathol. 2014;7:7536–44.
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 7536-7544
    • Qin, Y.1    Ye, G.X.2    Wu, C.J.3    Wang, S.4    Pan, D.B.5
  • 36
    • 84904024562 scopus 로고    scopus 로고
    • Loss of T-cadherin (CDH-13) regulates AKT signaling and desensitizes cells to apoptosis in melanoma
    • COI: 1:CAS:528:DC%2BC3sXms1Cjtbo%3D, PID: 23625515
    • Bosserhoff AK, Ellmann L, Quast AS, Eberle J, Boyle GM, et al. Loss of T-cadherin (CDH-13) regulates AKT signaling and desensitizes cells to apoptosis in melanoma. Mol Carcinog. 2014;53:635–47.
    • (2014) Mol Carcinog , vol.53 , pp. 635-647
    • Bosserhoff, A.K.1    Ellmann, L.2    Quast, A.S.3    Eberle, J.4    Boyle, G.M.5
  • 37
    • 84929440509 scopus 로고    scopus 로고
    • Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer
    • PID: 25928246
    • Wen W, Wu J, Liu L, Tian Y, Buettner R, et al. Synergistic anti-tumor effect of combined inhibition of EGFR and JAK/STAT3 pathways in human ovarian cancer. Mol Cancer. 2015;14:100.
    • (2015) Mol Cancer , vol.14 , pp. 100
    • Wen, W.1    Wu, J.2    Liu, L.3    Tian, Y.4    Buettner, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.