MEGSA: A Powerful and Flexible Framework for Analyzing Mutual Exclusivity of Tumor Mutations

American Journal of Human Genetics

Volumn 98, Issue 3, 2016, Pages 442-455

  Hua, Xing ^a   Hyland, Paula L ^a   Huang, Jing ^a   Song, Lei ^a   Zhu, Bin ^a   Caporaso, Neil E ^a   Landi, Maria Teresa ^a   Chatterjee, Nilanjan ^a   Shi, Jianxin ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

driver genes; mutual exclusivity; oncogenic pathways; tumor sequencing

Indexed keywords

CD135 ANTIGEN; ISOCITRATE DEHYDROGENASE 2; NUCLEOPHOSMIN; PROTEIN KINASE B; PROTEIN P53; RETINOBLASTOMA BINDING PROTEIN 2; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR RUNX1; UVOMORULIN; AKT1 PROTEIN, HUMAN; ARID1A PROTEIN, HUMAN; CELL RECEPTOR; FLT3 PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATASE; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 2, HUMAN; MED23 PROTEIN, HUMAN; MEDIATOR COMPLEX; MEMBRANE PROTEIN; NRAS PROTEIN, HUMAN; NUCLEAR PROTEIN; REPRESSOR PROTEIN; RUNX1 PROTEIN, HUMAN; STEM CELL FACTOR RECEPTOR; TBL1XR1 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; BREAST CANCER; CANCER GENETICS; CANCER SURVIVAL; CELL PROLIFERATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; GENE MUTATION; HUMAN; MULTIPLE CANCER; MUTATION RATE; MUTUALLY EXCLUSIVE GENE SETS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOMATIC MUTATION; TUMOR GENE; BIOLOGY; BREAST TUMOR; DNA SEQUENCE; FEMALE; GENETICS; GENOME-WIDE ASSOCIATION STUDY; LEUKEMIA, MYELOID, ACUTE; MOLECULAR MODEL; MUTATION; PROCEDURES; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; COMPUTATIONAL BIOLOGY; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FEMALE; FMS-LIKE TYROSINE KINASE 3; GENOME-WIDE ASSOCIATION STUDY; GTP PHOSPHOHYDROLASES; HUMANS; ISOCITRATE DEHYDROGENASE; LEUKEMIA, MYELOID, ACUTE; MEDIATOR COMPLEX; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTATION; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPRESSOR PROTEINS; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84960082742     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2015.12.021     Document Type: Article

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