Anti-diabetic activities of catalpol in db/db mice

Korean Journal of Physiology and Pharmacology

Volumn 20, Issue 2, 2016, Pages 153-160

  Bao, Qinwen ^a   Shen, Xiaozhu ^a   Qian, Li ^a   Gong, Chen ^a   Nie, Maoxiao ^a   Dong, Yan ^a  

^a Lianyungang Second People's Hospital of Jiangsu Province East Hospital   (China)

Author keywords

Adiponection; AMPK; Catalpol db db mice

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADIPONECTIN; CATALPOL; CHOLESTEROL; GLUCOSE; GLUCOSE TRANSPORTER 4; HYDROXYMETHYL GLUTARIC ACID ACYL COENZYME A REDUCTASE; INSULIN; MESSENGER RNA; METFORMIN; OXIDOREDUCTASE; PLASMA PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING;

EID: 84959886688     PISSN: 12264512     EISSN: 20933827     Source Type: Journal    
DOI: 10.4196/kjpp.2016.20.2.153     Document Type: Article

References (35)

1. Jiménez-Flores L.M., López-Briones S, Macías-Cervantes MH, Ramírez-Emiliano J, Pérez-Vázquez V. A PPARγ, NF-kB and AMPK-dependent mechanism may be involved in the beneficial effects of curcumin in the diabetic db/db mice liver. Molecules. 2014; 19:8289-8302.
2. Chiang CK, Ho TI, Peng Y.S., Hsu SP, Pai MF, Yang SY, Hung K.Y., Wu KD. Rosiglitazone in diabetes control in hemodialysis patients with and without viral hepatitis infection: effectiveness and side effects. Diabetes Care. 2007; 30:3-7.
3. Wang Z, Wang J, Chan P. Treating type 2 diabetes mellitus with traditional chinese and Indian medicinal herbs. Evid Based Complement Alternat Med. 2013; 2013:343594.
4. Pungitore CR, Ayub MJ, Borkowski E.J., Tonn CE, Ciuffo GM. Inhibition of Taq DNA polymerase by catalpol. Cell Mol Biol (Noisy-le-grand). 2004; 50:767-772.
5. Wei M, Lu Y, Liu D., Ru W. Ovarian failure-resistant effects of catalpol in aged female rats. Biol Pharm Bull. 2014; 37:1444-1449.
6. Jiang B, Shen RF, Bi J, Tian X.S., Hinchliffe T., Xia Y. Catalpol: a potential therapeutic for neurodegenerative diseases. Curr Med Chem. 2015; 22:1278-1291.
7. Li X, Xu Z, Jiang Z., Sun L, Ji J, Miao J., Zhang X, Li X, Huang S., Wang T, Zhang L. Hypoglycemic effect of catalpol on high-fat diet/ streptozotocin-induced diabetic mice by increasing skeletal muscle mitochondrial biogenesis. Acta Biochim Biophys Sin (Shanghai). 2014; 46:738-748.
8. Shieh JP, Cheng KC, Chung H.H., Kerh YF, Yeh CH, Cheng JT. Plasma glucose lowering mechanisms of catalpol, an active principle from roots of Rehmannia glutinosa, in streptozotocin-induced diabetic rats. J Agric Food Chem. 2011; 59:3747-3753.
9. Bogdanov P, Corraliza L, Villena J.A., Carvalho AR, Garcia-Arumí J, Ramos D, Ruberte J, Simó R, Hernández C. The db/db mouse: a useful model for the study of diabetic retinal neurodege-neration. PLoS One. 2014; 9:e97302.
10. Zhang C, Gui L, Xu Y., Wu T, Liu D. Preventive effects of androgra-pholide on the development of diabetes in autoimmune diabetic NOD mice by inducing immune tolerance. Int Immunopharmacol. 2013; 16:451-456.
11. Pentinat T, Ramon-Krauel M, Cebria J., Diaz R, Jimenez-Chillaron JC. Transgenerational inheritance of glucose intolerance in a mouse model of neonatal overnutrition. Endocrinology. 2010; 151:5617-5623.
12. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001; 29:e45.
13. Zhang XD, Yan JW, Yan G.R., Sun XY, Ji J, Li YM, Hu Y.H., Wang HY. Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice. Acta Pharmacol Sin. 2010; 31:1470-1477.
14. Sattar N, Gill JM Type 2 diabetes as a disease of ectopic fat? BMC Med. 2014; 12:123.
15. Wang G, Xu X, Yao X., Zhu Z, Yu L, Chen L., Chen J, Shen X. Latanoprost effectively ameliorates glucose and lipid disorders in db/db and ob/ob mice. Diabetologia. 2013; 56:2702-2712.
16. Zhong X, Chung AC, Chen H.Y., Dong Y., Meng XM, Li R, Yang W, Hou F.F., Lan HY. miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes. Diabetologia. 2013; 56:663-674.
17. Kang SJ, Lee JE, Lee E.K., Jung DH, Song CH, Park SJ, Choi S.H., Han CH, Ku SK, Lee YJ. Fermentation with Aquilariae Lignum enhances the anti-diabetic activity of green tea in type II diabetic db/db mouse. Nutrients. 2014; 6:3536-3571.
18. Dong Z, Chen CX Effect of catalpol on diabetic nephropathy in rats. Phytomedicine. 2013; 20:1023-1029.
19. Huang WJ, Niu HS, Lin M.H., Cheng JT, Hsu FL. Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats. J Nat Prod. 2010; 73:1170-1172.
20. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res. 2001; 50:537-546.
21. Farese RV, Lee MC, Sajan MP Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus. Expert Opin Ther Targets. 2014; 18:1163-1175.
22. Kim S, Jung J, Kim H., Heo RW, Yi CO, Lee JE, Jeon B.T., Kim WH, Hahm JR, Roh GS. Exendin-4 improves nonalcoholic fatty liver disease by regulating glucose transporter 4 expression in ob/ob mice. Korean J Physiol Pharmacol. 2014; 18:333-339.
23. Coughlan KA, Valentine RJ, Ruderman N.B., Saha AK. AMPK activation: a therapeutic target for type 2 diabetes Diabetes Metab Syndr Obes. 2014; 7:241-253.
24. Kurth-Kraczek E.J., Hirshman MF, Goodyear L.J., Winder WW. 5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes. 1999; 48:1667-1671.
25. Yamaguchi S, Katahira H, Ozawa S., Nakamichi Y, Tanaka T, Shimoyama T., Takahashi K, Yoshimoto K, Imaizumi M.O., Nagamatsu S., Ishida H. Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab. 2005; 289:E643-E649.
26. Steinberg GR, Kemp BE AMPK in Health and Disease. Physiol Rev. 2009; 89:1025-1078.
27. Hu N, Yuan L, Li H.J., Huang C., Mao QM, Zhang YY, Lin M, Sun Y.Q., Zhong XY, Tang P, Lu X. Anti-diabetic activities of jiaotaiwan in db/db mice by augmentation of AMPK protein activity and upregulation of GLUT4 expression. Evid Based Complement Alternat Med. 2013; 2013:180721.
28. Biden TJ, Boslem E, Chu K.Y., Sue N. Lipotoxic endoplasmic reticulum stress, ? cell failure, and type 2 diabetes mellitus. Trends Endocrinol Metab. 2014; 25:389-398.
29. Henin N, Vincent MF, Gruber H.E., Van den Berghe G. Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase. FASEB J. 1995; 9:541-546.
30. Maeda K, Okubo K, Shimomura I., Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun. 1996; 221:286-289.
31. Yamauchi T, Kamon J, Ito Y., Tsuchida A, Yokomizo T, Kita S., Sugiyama T, Miyagishi M, Hara K., Tsunoda M, Murakami K, Ohteki T., Uchida S, Takekawa S, Waki H., Tsuno NH, Shibata Y, Terauchi Y, Froguel P., Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003; 423:762-769.
32. Coimbra S, Brandão Proencã J, Santos-Silva A, Neuparth MJ. Adiponectin, leptin, and chemerin in elderly patients with type 2 diabetes mellitus: a close linkage with obesity and length of the disease. Biomed Res Int. 2014; 2014:701915.
33. Yamauchi T, Kamon J, Minokoshi Y., Ito Y, Waki H, Uchida S., Yamashita S, Noda M, Kita S., Ueki K, Eto K, Akanuma Y., Froguel P, Foufelle F, Ferre P., Carling D, Kimura S, Nagai R., Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002; 8:1288-1295.
34. Xie W, Wang L, Dai Q., Yu H, He X, Xiong J., Sheng H, Zhang D, Xin R., Qi Y, Hu F, Guo S., Zhang K. Activation of AMPK restricts coxsackievirus B3 replication by inhibiting lipid accumulation. J Mol Cell Cardiol. 2015; 85:155-167.
35. Fujita H, Fujishima H, Koshimura J., Hosoba M, Yoshioka N, Shimotomai T., Morii T, Narita T, Kakei M., Ito S. Effects of antidia-betic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db mice. Endocr J. 2005; 52:427-433.