Optimizing transplantation of sensitized heart candidates using 4 antibody detection assays to prioritize the assignment of unacceptable antigens

Journal of Heart and Lung Transplantation

Volumn 35, Issue 2, 2016, Pages 165-172

  Reinsmoen, Nancy L ^a   Patel, Jignesh ^a   Mirocha, James ^a   Lai, Chih Hung ^a   Naim, Mehrnoush ^a   Ong, Geraldine ^a   Wang, Qi ^a   Zhang, Xiaohai ^a   Liou, Frank ^a   Yu, Zhe ^a   Kobashigawa, Jon ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

C1q; CDC; CPRA; heart transplant; solid phase antibody testing; unacceptable antigen

Indexed keywords

BORTEZOMIB; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1Q ANTIBODY; CORTICOSTEROID; ECULIZUMAB; HLA A ANTIGEN; HLA A23 ANTIGEN; HLA ANTIBODY; HLA ANTIGEN; HLA B ANTIGEN; HLA B44 ANTIGEN; HLA B81 ANTIGEN; HLA DR ANTIGEN; HLA DR53 ANTIGEN; HLA DR7 ANTIGEN; IMMUNOGLOBULIN; MYCOPHENOLIC ACID; RITUXIMAB; TACROLIMUS; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG; ALLOANTIBODY;

ADULT; ANTIBODY DETECTION; ANTIBODY MEDIATED REJECTION; ANTIGEN ANTIBODY REACTION; ARTICLE; CARDIAC GRAFT REJECTION; CLASSIFICATION ALGORITHM; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; DESENSITIZATION; DILUTION; FEMALE; FLOW CYTOMETER; FLUORESCENCE ANALYSIS; GRAFT RECIPIENT; HEART TRANSPLANTATION; HLA SYSTEM; HUMAN; IMMUNOASSAY; IMMUNOLOGY TEST KIT; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; PLASMAPHERESIS; PRIORITY JOURNAL; SENSITIZATION; SURVIVAL RATE; ALGORITHM; CARDIAC MUSCLE; DONOR; FLOW CYTOMETRY; HISTOCOMPATIBILITY TEST; IMMUNOLOGY; POSTOPERATIVE CARE;

ALGORITHMS; DESENSITIZATION, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; HEART TRANSPLANTATION; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; IMMUNOSUPPRESSION; ISOANTIBODIES; MALE; MIDDLE AGED; MYOCARDIUM; POSTOPERATIVE CARE; TISSUE DONORS;

EID: 84959871405     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2015.10.013     Document Type: Article

References (40)

1. M.R. Mickey, G. Ayoub, and P.I. Terasaki Prediction of negative crossmatch: an aid for cost-effective kidney sharing Transplant Proc 14 1982 279 281
2. J.W. Oldfather, C.B. Anderson, D.L. Phelan, and et al. Prediction of crossmatch outcome in highly sensitized dialysis patients based on the identification of serum HLA antibodies Transplantation 42 1986 267 270
3. R.J. Fulton, R.L. McDade, P.L. Smith, and et al. Advanced multiplexed analysis with the FlowMetrix system Clin Chem 43 1997 1749 1756
4. Y. Itoh, N. Mizuki, T. Shimada, and et al. High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population Immunogenetics 57 2005 717 729
5. A.A. Zachary, J.T. Sholander, J.A. Houp, and et al. Using real data for a virtual crossmatch Hum Immunol 70 2009 575 579
6. J.Z. Appel III, M.G. Hartwig, E. Cantu III, and et al. Role of flow cytometry to define unacceptable HLA antigens in lung transplant recipients with HLA-specific antibodies Transplantation 81 2006 1049 1057
7. H.M. Gebel, and R.A. Bray HLA antibody detection with solid phase assays: great expectations or expectations too great? Am J Transplant 14 2012 1964 1975
8. A.A. Zachary, R.A. Montgomery, and M.S. Leffell Defining unacceptable HLA antigens Curr Opin Organ Transplant 13 2008 405 410
9. A.A. Zachary, and M.S. Leffell Detecting and monitoring human leukocyte antigen-specific antibodies Hum Immunol 69 2008 591 604
10. N.L. Reinsmoen, C.H. Lai, A. Vo, and et al. Acceptable donor-specific antibody levels allowing for successful deceased and living donor kidney transplantation after desensitization therapy Transplantation 86 2008 820 825
11. C.H. Lai, K. Cao, G. Ong, and et al. Antibody testing strategies for deceased donor kidney transplantation after immunomodulatory therapy Transplantation 92 2011 48 53
12. J.M. Cecka, A.Y. Kucheryavaya, N.L. Reinsmoen, and et al. Calculated PRA: initial results show benefits for sensitized patients and a reduction in positive crossmatches Am J Transplant 11 2011 719 724
13. S.D. Zangwill, T.M. Ellis, J. Zlotocha, and et al. The virtual crossmatch - a screening tool for sensitized pediatric heart transplant recipients Pediatr Transplant 10 2006 38 41
14. S. Zangwill, T. Ellis, G. Stendahl, and et al. Practical application of the virtual crossmatch Pediatr Transplant 11 2007 650 654
15. N. Nikaein, W. Cherikh, K. Nelson, and et al. Organ Procurement and Transplantation Network/United Network for Organ Sharing Histocompatibility Committee collaborative study to evaluate prediction of crossmatch results in highly sensitized patients Transplantation 87 2009 557 562
16. A.R. Tambur, D.S. Ramon, D.B. Kaufman, and et al. Perception versus reality? Virtual crossmatch - how to overcome some of the technical and logistic limitations Am J Transplant 9 2009 1886 1893
17. J.A. Kobashigawa, J.K. Patel, M.M. Kittleson, and et al. The long-term outcome of treated sensitized patients who undergo heart transplantation Clin Transplant 25 2011 E61 E67
18. J.K. Patel, M. Kittleson, and J.A. Kobashigawa Everolimus for cardiac allograft vasculopathy-every patient, at any time? Cardiac allograft rejection Surgeon 9 2011 160 167
19. J. Patel, M. Everly, D. Chang, and et al. Reduction of alloantibodies via proteasome inhibition in cardiac transplantation J Heart Lung Transplant 30 2011 1320 1326
20. J.G. Berry, A. Angelini, M.M. Burke, and et al. The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: evolution and current status (2005-2011) J Heart Lung Transplant 30 2011 601
21. G. Chen, F. Sequeira, and D.B. Tyan Novel C1q assay reveals a clinically relevant subset of human leukocyte antigen antibodies independent of immunoglobulin G strength on single antigen beads Hum Immunol 72 2011 849 858
22. C. Chin, G. Chen, F. Sequeria, and et al. Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients J Heart Lung Transplant 30 2011 158 163
23. A. Zeevi, J. Lunz, B. Feingold, and et al. Persistent strong anti-HLA antibody at high titer is complement binding and associated with increased risk of antibody-mediated rejection in heart transplant recipients J Heart Lung Transplant 32 2013 98 105
24. A. Loupy, C. Lefaucheur, D. Vernerey, and et al. Complement-binding anti-HLA antibodies and kidney allograft survival N Engl J Med 369 2013 1215 1226
25. S. Schaub, G. Honger, M.T. Koller, and et al. Determinants of C1q binding in the single antigen bead assay Transplantation 98 2014 387 393
26. M. Naim, C.H. Lai, G. Ong, and et al. Luminex single antigen C1q negative, CDC positive HLA specific antibodies Hum Immunol 74 Suppl 2013 74
27. H.G. Otten, M.C. Verhaar, H.P.E. Borst, and et al. Pretransplant donor-specific HLA class-I and -II antibodies are associated with an increased risk for kidney graft failure Am J Transplant 12 2012 1618 1623
28. M. Crespo, A. Torio, V. Mas, and et al. Clinical relevance of pretransplant anti-HLA donor-specific antibodies: does C1q-fixation matter? Transplant Immunol 29 2013 28 33
29. M. Schnaidt, C. Weinstock, M. Jurisic, and et al. HLA antibody specification using single-antigen beads - a technical solution for the prozone effect Transplantation 92 2011 510 515
30. M. Colvin-Adams, J.M. Smith, B.M. Heubner, and et al. OPTN/SRTR 2011 annual data report: heart Am J Transplant 13 2013 119 148
31. R. Yanagida, L.S. Czer, N.L. Reinsmoen, and et al. Impact of virtual crossmatch on waiting times for heart transplantation Ann Thorac Surg 92 2011 2104 2111
32. D. Dragun, R. Catar, and A. Philippe Non-HLA antibodies in solid organ transplantation: recent concepts and clinical relevance Curr Opin Organ Transplant 18 2013 430 435
33. D. Dragun, A. Philippe, and R. Catar Role of non-HLA antibodies in organ transplantation Transplantation 17 2012 440 445
34. N.L. Reinsmoen, C.H. Lai, H. Heidecke, and et al. Anti-angiotensin type 1 receptor antibodies associated with antibody mediated rejection in donor HLA antibody negative patients Transplantation 90 2010 1473 1477
35. D. Dragun, D.N. Muller, J.H. Brasen, and et al. Angiotension II type 1-receptor activating antibodies in renal-allograft rejection N Engl J Med 352 2005 558 569
36. N.L. Reinsmoen Role of angiotensin II type 1 receptor-activating antibodies in solid organ transplantation Hum Immunol 74 2013 1474 1477
37. N.L. Reinsmoen, C.H. Lai, J. Mirocha, and et al. Increased negative impact of donor HLA-specific together with non-HLA-specific antibodies on graft outcome Transplantation 97 2014 595 601
38. R. Kelsch, A.S. Everding, E. Kuwertz-Broking, and et al. Accelerated kidney transplant rejection and hypertensive encephalopathy in a pediatric patient associated with antibodies against angiotensin type 1 receptor and HLA class II Transplantation 92 2011 57 59
39. M. Giral, Y. Foucher, A. Dufay, and et al. Pre-transplant sensitization against angiotensin II type 1 receptor is a risk factor for acute rejection and graft loss Am J Transplant 13 2013 2567 2576
40. M. Taniguchi, L.M. Rebellato, J. Cai, and et al. Higher risk of kidney graft failure in the presence of anti-angiotensin II type-1 receptor antibodies Am J Transplant 13 2013 2577 2589