Role of angiotensin II type 1 receptor-activating antibodies in solid organ transplantation

Human Immunology

Volumn 74, Issue 11, 2013, Pages 1474-1477

  Reinsmoen, Nancy L ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTIBODY; ANTIBODY; ENDOTHELIN 1; HLA ANTIBODY; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G3 ANTIBODY; LYMPHOCYTE ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ANTIBODY MEDIATED REJECTION; ARTICLE; COMPLEMENT DEPENDENT CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART TRANSPLANTATION; HUMAN; HUMORAL IMMUNITY; HYPERTENSION; HYPERTENSION ENCEPHALOPATHY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LUNG TRANSPLANTATION; MALIGNANT HYPERTENSION; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; SECONDARY IMMUNE RESPONSE;

ANGIOTENSIN II; ANTIBODIES; HLA ANTIGENS; HUMANS; HYPERTENSION; ORGAN TRANSPLANTATION; RECEPTOR, ANGIOTENSIN, TYPE 2; TRANSPLANTATION IMMUNOLOGY;

EID: 84885046105     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2013.06.034     Document Type: Article

References (34)

1. Dzau V.J. Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. Hypertension 2001, 37:1047.
2. Dragun D. Humoral responses directed against non-human leukocyte antigens in solid-organ transplantation. Transplantation 2008, 86:1019-1025.
3. Miller J.A., Scholey J.W. The impact of renin-angiotensin polymorphisms on physiological and pathophysiological processes in humans. Curr Opin Nephrol Hypertens 2004, 13:101.
4. Bonnardeaux A., Davies E., Jeunemaitre X., Fery I., Charru A., Clauser E., et al. Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 1994, 24:63-69.
5. Nickeleit V., Mihatsch M.J. Kidney transplants, antibodies and rejection: is C4d a magic marker?. Nephrol Dial Transplant 2003, 18:2232.
6. Dragun D., Philippe A., Catar R. Role of non-HLA antibodies in organ transplantation. Transplantation 2012, 17:440-445.
7. Reinsmoen N.L., Lai C.H., Heidecke H., Haas M., Cao K., Ong G., et al. Anti-angiotensin type 1 receptor antibodies associated with antibody mediated rejection in donor HLA antibody negative patients. Transplantation 2010, 90:1473-1477.
8. Dragun D. The role of angiotensin II type 1 receptor-activating antibodies in renal allograft vascular rejection. Pediatr Nephrol 2007, 22:911-914.
9. Slowinski T., Suker D., Schonemann C. Screening of patients on waiting-list for a renal transplant for agonistic non-HLA antibodies targeting angiotensin II type 1 receptor (abstract). J Am Soc Nephrol 2006, 17:393A.
10. Dragun D., Muller D.N., Brasen J.H., Fritsche L., Nieminen-Kelha M., Dechend R., et al. Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection. N Engl J Med 2005, 352:558-569.
11. Wallukat G., Homuth V., Fischer T., Lindschau C., Horstkamp B., Jüpner A., et al. Patients with preeclampsia develop agonistic antibodies against the angiotensin AT1 receptor. J Clin Invest 1999, 103:945-952.
12. Fu M.I., Herlitz H., Schulze W., Wallukat G., Micke P., Eftekhari P., et al. Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension. J Hypertens 2000, 18:945-953.
13. Mellor A.L., Munn D.H. Immunology at the maternal-fetal interface: lessons for T cell tolerance and suppression. Annu Rev Immunol 2000, 18:367.
14. Amico P., Hönger G., Bielmann D., Lutz D., Garzoni D., Steiger J., et al. Incidence and prediction of early antibody-mediated rejection due to non-human leukocyte antigen-antibodies. Transplantation 2008, 85:1557-1563.
15. Scornik J.C., Guerra G., Schold J.D., Srinivas T.R., Dragun D., Meier-Kriesche H.U., et al. Value of posttransplant antibody tests in the evaluation of patients with renal graft dysfunction. Am J Transplant 2007, 7:1808.
16. Kelsch R., Everding A.S., Kuwertz-Bröking E., Brand E., Spriewald B.M., Sibrowski W., et al. Accelerated kidney transplant rejection and hypertensive encephalopathy in a pediatric patient associated with antibodies against angiotensin type 1 receptor and HLA class II. Transplantation 2011, 92:57-59.
17. Yousufuddin M., Cook D.J., Starling R.C., Abdo A., Paul P., Tuzcu M., et al. Angiotensin II receptors from peritransplantation through first-year-post-transplantation and the risk of transplant coronary artery disease. J Am Coll Cardiol 2004, 43:1565-1573.
18. Ruiz-Ortega M., Lorenzo O., Rupérez M., Esteban V., Suzuki Y., Mezzano S., et al. Role of renin-angiotensin system in vascular disease. Hypertension 2001, 38:1382-1391.
19. Yamani M.H., Cook D.J., Rodriguez E.R., Thomas D.M., Gupta S., Alster J., et al. Increased expression of angiotensin II type 1 receptor (AGTR1) in heart transplant recipients with recurrent rejection. J Heart Lung Transplant 2006, 25:1283-1289.
20. de Gasparo M., Catt K.J., Inagami T., Wright J.W., Unger T. International Union of Pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000, 52:415-472.
21. Schneider M.P., Boesen E.I., Pollock D.M. Contrasting actions of endothelin ET(A) and ET(B) receptors in cardiovascular disease. Annu Rev Pharmacol Toxicol 2007, 47:731.
22. Hiemann N.E., Wellnhofer E., Knosalla C., Lehmkuhl H.B., Stein J., Hetzer R., et al. Prognostic impact of microvasculopathy on survival after heart transplantation-evidence from 9713 endomyocardial biopsies. Circulation 2007, 116:1274-1282.
23. Hiemann N.E., Meyer R., Wellnhofer E., Schoenemann C., Heidecke H., Lachmann N., et al. Non-HLA antibodies targeting vascular receptors enhance alloimmune response and microvasculopathy after heart transplantation. Transplantation 2012, 94:919-924.
24. Hiemann N.E., Musci M., Wellnhofer E., Meyer R., Hetzer R. Light microscopic biopsy findings after heart transplantation and possible links to development of graft vessel disease. Transplant Proc 1999, 31:149-151.
25. Locke J.E., Zachary A.A., Warren D.S., Segev D.L., Houp J.A., Montgomery R.A., et al. Proinflammatory events are associated with significant increases in breadth and strength of HLA-specific antibody. Am J Transplant 2009, 9:2136-2139.
26. Eng H.S., Arnaoutakis G.J., Lucas D., George T.J., Beaty C.A., Merlo C.A., et al. Angiotensin II type 1 receptor sensitization in lung transplantation. Hum Immunol 2012, 73(Suppl.):61.
27. Arnaoutakis G.J., Eng H.S., George T.J., Beaty C.A., Merlo C.A., Shah A.S., et al. The impact of angiotensin II type 1 receptor auto-antibodies and early lung transplant outcomes. Am J Transplant 2012, 12(S3):170.
28. Win T.S., Pettigrew G.J. Humoral autoimmunity and transplant vasculopathy: when allo is not enough. Transplantation 2010, 90:113.
29. Schwimmbeck P.L., Dyrberg T., Drachman D.B., Oldstone M.B. Molecular mimicry and myasthenia gravis: an autoantigenic site of acetycholine receptor α-subunit that has biologic activity and reacts immuno-chemically with herpes simplex virus. J Clin Invest 1989, 84:1174.
30. Masuda M.O., Levin M., De Oliveira S.F., Dos Santos Costa P.C., Bergami P.L., Dos Santos Almeida N.A., et al. Functionally active cardiac antibodies in chronic Chagas' disease are specifically blocked by Trypanosoma cruzi antigens. FASEB J 1998, 12:1551.
31. Stepan H., Wallukat G., Schultheiss H.P., Faber R., Walther T. Is parvovirus B19 the cause for autoimmunity against angiotensin II type 1 receptor?. J Reprod Immunol 2007, 73:130.
32. Jackson A.M., Lucas D.P., Melancon J.K., Desai N.M. Clinical relevance and IgG subclass determination of non-HLA antibodies identified using endothelial cell precursors isolated from donor blood. Transplantation 2011, 92:54-60.
33. Porcheray F., DeVito J., Yeap B.Y., Xue L., Dargon I., Paine R., et al. Chronic humoral rejection of human kidney allografts associates with broad autoantibody responses. Transplantation 2010, 89:1239-1246.
34. Nath D.S., Basha H.I., Mohanakumar T. Antihuman leukocyte antigen antibody-induced autoimmunity: role in chronic rejection. Curr Opin Organ Transplant 2010, 15:16-20.