L-Lysine supplementation does not affect the bioavailability of copper or iron in rats

Journal of Trace Elements in Medicine and Biology

Volumn 38, Issue , 2016, Pages 194-200

  Bertinato, Jesse ^a,b   Lavergne, Christopher ^a   Vu, Nina A ^a,b   Plouffe, Louise J ^a   Wood, Carla ^a   Griffin, Philip ^a   Xiao, Chao Wu ^a,c  

^a Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c CARLETON UNIVERSITY   (Canada)

Author keywords

Bioavailability; Copper; Diet; Iron; L Lysine; Rat

Indexed keywords

CERULOPLASMIN; COPPER; IRON; LYSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BIOAVAILABILITY; BODY WEIGHT; BODY WEIGHT GAIN; CERULOPLASMIN BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; FOOD INTAKE; HEMATOLOGICAL PARAMETERS; INTESTINE MUCOSA; KIDNEY; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DIET; RAT; ANIMAL; DIETARY SUPPLEMENT; SPRAGUE DAWLEY RAT;

ANIMALS; BIOLOGICAL AVAILABILITY; COPPER; DIETARY SUPPLEMENTS; IRON; LYSINE; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84959866895     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2016.02.005     Document Type: Article

References (32)

1. Claeys, W.L., De Vleeschouwer, K., Hendrickx, M.E., Effect of amino acids on acrylamide formation and elimination kinetics. Biotechnol. Prog. 21 (2005), 1525–1530.
2. Griffith, R.S., Norins, A.L., Kagan, C., A multicentered study of lysine therapy in herpes simplex infection. Dermatologica 156 (1978), 257–267.
3. Griffith, R.S., Walsh, D.E., Myrmel, K.H., Thompson, R.W., Behforooz, A., Success of L-lysine therapy in frequently recurrent herpes simplex infection: treatment and prophylaxis. Dermatologica 175 (1987), 183–190.
4. McCune, M.A., Perry, H.O., Muller, S.A., O'Fallon, W.M., Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 34 (1984), 366–373.
5. Miller, C.S., Foulke, C.N., Use of lysine in treating recurrent oral herpes simplex infections. Gen. Dent. 32 (1984), 490–493.
6. Gaby, A.R., Natural remedies for herpes simplex. Altern. Med. Rev. 11 (2006), 93–101.
7. Civitelli, R., Villareal, D.T., Agnusdei, D., Nardi, P., Avioli, L.V., Gennari, C., Dietary L-lysine and calcium metabolism in humans. Nutrition 8 (1992), 400–405.
8. Furst, P., Dietary L-lysine supplementation: a promising nutritional tool in the prophylaxis and treatment of osteoporosis. Nutrition 9 (1993), 71–72.
9. Bertinato, J., L'Abbé M.R., Maintaining copper homeostasis: regulation of copper-trafficking proteins in response to copper deficiency or overload. J. Nutr. Biochem. 15 (2004), 316–322.
10. Bertinato, J., Copper: physiology. Caballero, B., Finglas, P., Toldrá F., (eds.) The Encyclopedia of Food and Health, vol. 2, 2016, Academic Press, Oxford, 321–326.
11. Beard, J.L., Iron biology in immune function, muscle metabolism and neuronal functioning. J. Nutr. 131 (2001), S568–S580.
12. Cockell, K.A., Bertinato, J., L'Abbé M.R., Regulatory frameworks for copper considering chronic exposures of the population. Am. J. Clin. Nutr. 88 (2008), S863–S866.
13. Mitchell, G.V., Jenkins, M.Y., Effect of excess L-lysine on rat growth and on plasma and tissue concentrations of copper, iron and zinc. J. Nutr. Sci. Vitaminol. 29 (1983), 709–715.
14. Gao, S., Yin, T., Xu, B., Ma, Y., Hu, M., Amino acid facilitates absorption of copper in the Caco-2 cell culture model. Life Sci. 109 (2014), 50–56.
15. Aoyagi, S., Baker, D.H., Copper–amino acid complexes are partially protected against inhibitory effects of L-cysteine and L-ascorbic acid on copper absorption in chicks. J. Nutr. 124 (1994), 388–395.
16. Rabiansky, P.A., McDowell, L.R., Velasquez-Pereira, J., Wilkinson, N.S., Percival, S.S., Martin, F.G., et al. Evaluating copper lysine and copper sulfate sources for heifers. J. Dairy Sci. 82 (1999), 2642–2650.
17. Apgar, G.A., Kornegay, E.T., Mineral balance of finishing pigs fed copper sulfate or a copper–lysine complex at growth-stimulating levels. J. Anim. Sci. 74 (1996), 1594–1600.
18. Kegley, E.B., Spears, J.W., Bioavailability of feed-grade copper sources (oxide, sulfate, or lysine) in growing cattle. J. Anim. Sci. 72 (1994), 2728–2734.
19. Reeves, P.G., Nielsen, F.H., Fahey, G.C. Jr., AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet. J. Nutr. 123 (1993), 1939–1951.
20. Schosinsky, K.H., Lehmann, H.P., Beeler, M.F., Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochloride. Clin. Chem. 20 (1974), 1556–1563.
21. Bertinato, J., Zouzoulas, A., Considerations in the development of biomarkers of copper status. J. AOAC Int. 92 (2009), 1541–1550.
22. Wapnir, R.A., Copper absorption and bioavailability. Am. J. Clin. Nutr. 67 (1998), S1054–S1060.
23. Conato, C., Contino, A., Maccarrone, G., Magrì A., Remelli, M., Tabbì G., Copper(II) complexes with L-lysine and L-ornithine: is the side-chain involved in the coordination? A thermodynamic and spectroscopic study. Thermochim. Acta 362 (2000), 13–23.
24. Bertinato, J., Sherrard, L., Plouffe, L.J., EDTA disodium zinc has superior bioavailability compared to common inorganic or chelated zinc compounds in rats fed a high phytic acid diet. J. Trace Elem. Med. Biol. 26 (2012), 227–233.
25. Bertinato, J., Plouffe, L.J., Lavergne, C., Ly, C., Bioavailability of magnesium from inorganic and organic compounds is similar in rats fed a high phytic acid diet. Magnes. Res. 27 (2014), 175–185.
26. Institute of Medicine, Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. 2005, National Academies Press, Washington, DC.
27. Roeser, H.P., Lee, G.R., Nacht, S., Cartwright, G.E., The role of ceruloplasmin in iron metabolism. J. Clin. Invest. 49 (1970), 2408–2417.
28. Nowland, M.H., Hugunin, K.M., Rogers, K.L., Effects of short-term fasting in male Sprague-Dawley rats. Comp. Med. 61 (2011), 138–144.
29. Matsuzawa, T., Sakazume, M., Effects of fasting on haematology and clinical chemistry values in the rat and dog. Comp. Haematol. Int. 4 (1994), 152–156.
30. Deckardt, K., Weber, I., Kaspers, U., Hellwig, J., Tennekes, H., van Ravenzwaay, B., The effects of inhalation anaesthetics on common clinical pathology parameters in laboratory rats. Food Chem. Toxicol. 45 (2007), 1709–1718.
31. Harvey, P.W., Hunsaker, H.A., Allen, K.G., Dietary L-histidine-induced hypercholesterolemia and hypocupremia in the rat. J. Nutr. 111 (1981), 639–647.
32. Lutsenko, S., Barnes, N.L., Bartee, M.Y., Dmitriev, O.Y., Function and regulation of human copper-transporting ATPases. Physiol. Rev. 87 (2007), 1011–1046.