EDTA disodium zinc has superior bioavailability compared to common inorganic or chelated zinc compounds in rats fed a high phytic acid diet

Journal of Trace Elements in Medicine and Biology

Volumn 26, Issue 4, 2012, Pages 227-233

  Bertinato, Jesse ^a   Sherrard, Lindsey ^a   Plouffe, Louise J ^a  

^a Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals   (Canada)

Author keywords

Bioavailability; EDTA disodium zinc; Phytic acid; Rat; Zinc

Indexed keywords

EDETATE DISODIUM ZINC; GLUCONATE ZINC; HEMOGLOBIN; PHYTIC ACID; UNCLASSIFIED DRUG; ZINC ACETATE; ZINC CITRATE; ZINC DERIVATIVE; ZINC OROTATE; ZINC OXIDE; ZINC SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DIETARY INTAKE; FEMUR; GROWTH; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE LEVEL; WEIGHT GAIN; ZINC BLOOD LEVEL; ZINC DEFICIENCY;

ANIMALS; DIETARY SUPPLEMENTS; EDETIC ACID; MALE; PHYTIC ACID; RATS; RATS, SPRAGUE-DAWLEY; ZINC;

RATTUS;

EID: 84868205265     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2012.04.008     Document Type: Article

References (40)

1. Hess S.Y., Lonnerdal B., Hotz C., Rivera J.A., Brown K.H. Recent advances in knowledge of zinc nutrition and human health. Food Nutr Bull 2009, 30:S5-S11.
2. Brown K.H., Rivera J.A., Bhutta Z., Gibson R.S., King J.C., Lonnerdal B., et al. International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull 2004, 25:S99-S203.
3. Brown K.H., Peerson J.M., Baker S.K., Hess S.Y. Preventive zinc supplementation among infants, preschoolers, and older prepubertal children. Food Nutr Bull 2009, 30:S12-S40.
4. Brown K.H., Hambidge K.M., Ranum P. Zinc fortification of cereal flours: current recommendations and research needs. Food Nutr Bull 2010, 31:S62-S74.
5. Brown K.H., Lopez de Romana D., Arsenault J.E., Peerson J.M., Penny M.E. Comparison of the effects of zinc delivered in a fortified food or a liquid supplement on the growth, morbidity, and plasma zinc concentrations of young Peruvian children. Am J Clin Nutr 2007, 85:538-547.
6. Lo N.B., Aaron G.J., Hess S.Y., Dossou N.I., Guiro A.T., Wade S., et al. Plasma zinc concentration responds to short-term zinc supplementation, but not zinc fortification, in young children in Senegal. Am J Clin Nutr 2011, 93:1348-1355.
7. Arsenault J.E., Lopez de Romana D., Penny M.E., Van Loan M.D., Brown K.H. Additional zinc delivered in a liquid supplement, but not in a fortified porridge, increased fat-free mass accrual among young Peruvian children with mild-to-moderate stunting. J Nutr 2008, 138:108-114.
8. Hambidge K.M., Kin J.C., Kern D.L., English-Westcott J.L., Stall C. Pre-breakfast plasma zinc concentrations: the effect of previous meals. J Trace Elem Electrolytes Health Dis 1990, 4:229-231.
9. Gibson R.S., Bailey K.B., Gibbs M., Ferguson E.L. A review of phytate, iron, zinc, and calcium concentrations in plant-based complementary foods used in low-income countries and implications for bioavailability. Food Nutr Bull 2010, 31:S134-S146.
10. Hallberg L., Rossander L., Skanberg A.B. Phytates and the inhibitory effect of bran on iron absorption in man. Am J Clin Nutr 1987, 45:988-996.
11. Herman S., Griffin I.J., Suwarti S., Ernawati F., Permaesih D., Pambudi D., et al. Cofortification of iron-fortified flour with zinc sulfate, but not zinc oxide, decreases iron absorption in Indonesian children. Am J Clin Nutr 2002, 76:813-817.
12. Hotz C., DeHaene J., Woodhouse L.R., Villalpando S., Rivera J.A., King J.C. Zinc absorption from zinc oxide, zinc sulfate, zinc oxide+EDTA, or sodium-zinc EDTA does not differ when added as fortificants to maize tortillas. J Nutr 2005, 135:1102-1105.
13. Lopez de Romana D., Lonnerdal B., Brown K.H. Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide. Am J Clin Nutr 2003, 78:279-283.
14. Mendoza C., Peerson J.M., Brown K.H., Lonnerdal B. Effect of a micronutrient fortificant mixture and 2 amounts of calcium on iron and zinc absorption from a processed food supplement. Am J Clin Nutr 2004, 79:244-250.
15. 2EDTA enhances the absorption of iron and zinc from fortified rice flour in Sri Lankan children. J Nutr 2004, 134:3031-3036.
16. Davidsson L., Kastenmayer P., Hurrell R.F. Sodium iron EDTA [NaFe(III)EDTA] as a food fortificant: the effect on the absorption and retention of zinc and calcium in women. Am J Clin Nutr 1994, 60:231-237.
17. Hempe J.M., Cousins R.J. Effect of EDTA and zinc-methionine complex on zinc absorption by rat intestine. J Nutr 1989, 119:1179-1187.
18. Cockell K.A., Fischer P.W., Belonje B. Elemental composition of anatomically distinct regions of rat liver. Biol Trace Elem Res 1999, 70:251-263.
19. Yonekura L., Suzuki H. Effects of dietary zinc levels, phytic acid and resistant starch on zinc bioavailability in rats. Eur J Nutr 2005, 44:384-391.
20. Sandstrom B., Sandberg A.S. Inhibitory effects of isolated inositol phosphates on zinc absorption in humans. J Trace Elem Electrolytes Health Dis 1992, 6:99-103.
21. Lonnerdal B., Sandberg A.S., Sandstrom B., Kunz C. Inhibitory effects of phytic acid and other inositol phosphates on zinc and calcium absorption in suckling rats. J Nutr 1989, 119:211-214.
22. Institute of Medicine Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium and zinc 2001, National Academy of Sciences, Washington, DC.
23. Khokhar S., Pushpanjali, Fenwick R.G. Phytate content of Indian foods and intakes by vegetarian Indians of Hisar region, Haryana State. J Agric Food Chem 1994, 42:2440-2444.
24. Hunt J.R., Johnson L.K. Dietary protein, as egg albumen: effects on bone composition, zinc bioavailability and zinc requirements of rats, assessed by a modified broken-line model. J Nutr 1992, 122:161-169.
25. Bettger W.J., Savage J.E., O'Dell B.L. Extracellular zinc concentration and water metabolism in chicks. J Nutr 1981, 111:1013-1019.
26. Kirchgessner M., Stadler A.E., Roth H.P. Carbonic anhydrase activity and erythrocyte count in the blood of zinc-deficient rats. Bioinorg Chem 1975, 5:33-38.
27. Paterson P.G., Bettger W.J. Effect of dietary zinc intake on the hematological profile of the rat. Comp Biochem Physiol A: Comp Physiol 1986, 83:721-725.
28. El Hendy H.A., Yousef M.I., Abo El-Naga N.I. Effect of dietary zinc deficiency on hematological and biochemical parameters and concentrations of zinc, copper, and iron in growing rats. Toxicology 2001, 167:163-170.
29. O'Dell B.L., Browning J.D., Reeves P.G. Zinc deficiency increases the osmotic fragility of rat erythrocytes. J Nutr 1987, 117:1883-1889.
30. Konomi A., Yokoi K. Zinc deficiency decreases plasma erythropoietin concentration in rats. Biol Trace Elem Res 2005, 107:289-292.
31. Hurrell R.F., Reddy M.B., Burri J., Cook J.D. An evaluation of EDTA compounds for iron fortification of cereal-based foods. Br J Nutr 2000, 84:903-910.
32. Hurrell R., Ranum P., de Pee S., Biebinger R., Hulthen L., Johnson Q., et al. Revised recommendations for iron fortification of wheat flour and an evaluation of the expected impact of current national wheat flour fortification programs. Food Nutr Bull 2010, 31:S7-S21.
33. Lanigan R.S., Yamarik T.A. Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. Int J Toxicol 2002, 21(Suppl. 2):95-142.
34. Greiner R., Konietzny U. Phytase for food application. Food Technol Biotechnol 2006, 44(2):125-140.
35. Scrimgeour A.G., Marchitelli L.J., Whicker J.S., Song Y., Ho E., Young A.J. Phytase supplementation increases bone mineral density, lean body mass and voluntary physical activity in rats fed a low-zinc diet. J Nutr Biochem 2010, 21:653-658.
36. McClung J.P., Stahl C.H., Marchitelli L.J., Morales-Martinez N., Mackin K.M., Young A.J., et al. Effects of dietary phytase on body weight gain, body composition and bone strength in growing rats fed a low-zinc diet. J Nutr Biochem 2006, 17:190-196.
37. Rimbach G., Brandt K., Most E., Pallauf J. Supplemental phytic acid and microbial phytase change zinc bioavailability and cadmium accumulation in growing rats. J Trace Elem Med Biol 1995, 9:117-122.
38. Thacher T.D., Aliu O., Griffin I.J., Pam S.D., O'Brien K.O., Imade G.E., et al. Meals and dephytinization affect calcium and zinc absorption in Nigerian children with rickets. J Nutr 2009, 139:926-932.
39. 3+EDTA as a food fortificant: influence on zinc, calcium and copper metabolism in the rat. Br J Nutr 1994, 71:85-93.
40. Kratzer F.H., Allred J.B., Davis P.N., Marshall B.J., Vohra P. The effect of autoclaving soybean protein and the addition of ethylenediaminetetraacetic acid on the biological availability of dietary zinc for turkey poults. J Nutr 1959, 68:313-322.