Gram-negative bacteraemia; A multi-centre prospective evaluation of empiric antibiotic therapy and outcome in English acute hospitals

Clinical Microbiology and Infection

Volumn 22, Issue 3, 2016, Pages 244-251

  Fitzpatrick, J M ^a   Biswas, J S ^b   Edgeworth, J D ^b   Islam, J ^c   Jenkins, N ^d   Judge, R ^e   Lavery, A J ^f   Melzer, M ^g   Morris Jones, S ^f   Nsutebu, E F ^h   Peters, J ^a   Pillay, D G ^d   Pink, F ^g   Price, J R ⁱ   Scarborough, M ^j   Thwaites, G E ^k   Tilley, R ^e   Walker, A S ^j,k   Llewelyn, M J ^a,l  

^a ROYAL SUSSEX COUNTY HOSPITAL   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c SURREY AND SUSSEX HEALTHCARE NHS TRUST   (United Kingdom)

^d UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^e PLYMOUTH HOSPITALS NHS TRUST   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^g BARTS HEALTH NHS TRUST   (United Kingdom)

^h ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

ⁱ Worthing Hospital   (United Kingdom)

^j JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^k UNIVERSITY OF OXFORD   (United Kingdom)

^l BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

more..

Author keywords

Adult; Antibiotic therapy; Bloodstream infection; Gram negative bacteria; Mortality

Indexed keywords

AMINOGLYCOSIDE; AMOXICILLIN PLUS CLAVULANIC ACID; PIPERACILLIN PLUS TAZOBACTAM; ANTIINFECTIVE AGENT;

ABDOMINAL INFECTION; ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BILIARY TRACT INFECTION; BLOOD CULTURE; BLOOD SAMPLING; DISEASE SEVERITY; ESCHERICHIA COLI; FEMALE; GRAM NEGATIVE SEPSIS; HOSPITAL; HUMAN; KLEBSIELLA; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; MULTICENTER STUDY; PRIORITY JOURNAL; PSEUDOMONAS; SURVIVAL; TREATMENT OUTCOME; URINARY TRACT INFECTION; BACTEREMIA; CAUSE OF DEATH; CLINICAL TRIAL; COMORBIDITY; ENGLAND; EPIDEMIOLOGY; GRAM-NEGATIVE BACTERIAL INFECTIONS; MICROBIOLOGY; MIDDLE AGED; PROSPECTIVE STUDY; RISK FACTOR; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTEREMIA; CAUSE OF DEATH; COMORBIDITY; ENGLAND; FEMALE; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; TREATMENT OUTCOME;

EID: 84959575451     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1016/j.cmi.2015.10.034     Document Type: Article

References (30)

1. Goto M., Al-Hasan M.N. Overall burden of bloodstream infection and nosocomial bloodstream infection in North America and Europe. Clin Microbiol Infect 2013, 19:501-509.
2. de Kraker M.E., Jarlier V., Monen J.C., Heuer O.E., van de Sande N., Grundmann H. The changing epidemiology of bacteraemias in Europe: trends from the European Antimicrobial Resistance Surveillance System. Clin Microbiol Infect 2013, 19:860-868.
3. Laupland K.B. Incidence of bloodstream infection: a review of population-based studies. Clin Microbiol Infect 2013, 19:492-500.
4. Antimicrobial resistance surveillance in Europe 2013. European Centre for Disease Prevention and Control. Available at: http://ecdc.europa.eu/en/publications/Documents/antibiotic-resistance-in-EU-summary.pdf.
5. Llewelyn M.J., Hand K., Hopkins S., Walker A.S. Antibiotic policies in acute English NHS trusts: implementation of 'Start Smart-Then Focus' and relationship with Clostridium difficile infection rates. J Antimicrob Chemother 2015, 70:1230-1235.
6. Anderson D.J., Moehring R.W., Sloane R., Schmader K.E., Weber D.J., Fowler V.G., et al. Bloodstream infections in community hospitals in the 21st century: a multicenter cohort study. PlosOne 2014, 9:e91713.
7. Policy statement on antimicrobial stewardship by the Society for Healthcare Epidemiology of America (SHEA), the Infectious Diseases Society of America (IDSA), and the Pediatric Infectious Diseases Society (PIDS). Infect Control Hosp Epidemiol 2012, 33:322-327.
8. Dellinger P., Levy M.M., Rhodes A., Annane D., Gerlach H., Opal S.M., et al. Surviving sepsis campaign: international guidelines for the management of severe sepsis and septic shock 2012. Crit Care Med 2013, 41:580-637.
9. Paul M., Shani V., Muchtar E., Kariv G., Robenshtok E., Leibovici L., et al. Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis. Antimicrob Agents Chemother 2010, 54:4851-4863.
10. de Groot B., Ansems A., Gerling D.H., Rijpsma D., van Amstel P., Linzel D., et al. The association between time to antibiotics and relevant clinical outcomes in emergency department patients with various stages of sepsis: a prospective multi-center study. Crit Care 2015, 19:194-205.
11. Hranjec T., Rosenberger L.H., Swenson B., Metzger R., Flohr T.R., Politano A.D., et al. Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study. Lancet Infect Dis 2012, 12:774-780.
12. Pedersen G., Schonheyder H.C., Sorensen H.T. Antibiotic therapy and outcome of monomicrobial Gram-negative bacteraemia: a 3-year population-based study. Scand J Infect Dis 1997, 29:601-606.
13. Leibovici L., Shraga I., Drucker M., Konigsberger H., Samra Z., Pitlik S.D. The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med 1998, 244:379-386.
14. Ibrahim E.H., Sherman G., Ward S., Fraser V.J., Kollef M.H. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 2000, 118:146-155.
15. Micek S.T., Lloyd A.E., Ritchie D.J., Reichley R.M., Fraser V.J., Kollef M.H. Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother 2005, 49:1306-1311.
16. Scarsi K.K., Feinglass J.M., Scheetz M.H., Postelnick M.J., Bolon M.K., Noskin G.A. Impact of inactive empiric antimicrobial therapy on inpatient mortality and length of stay. Antimicrob Agents Chemother 2006, 50:3355-3360.
17. Cheong H.S., Kang C.I., Kwon K.T., Heo S.T., Wi Y.M., Kim E.S., et al. Clinical significance of healthcare-associated infections in community-onset Escherichia coli bacteraemia. J Antimicrob Chemother 2007, 60:1355-1360.
18. Lodise T.P., Patel N., Kwa A., Graves J., Furuno J.P., Graffunder E., et al. Predictors of 30-day mortality among patients with Pseudomonas aeruginosa bloodstream infections: impact of delayed appropriate antibiotic selection. Antimicrob Agents Chemother 2007, 51:3510-3515.
19. Peralta G., Sanchez M.B., Garrido J.C., De Benito I., Cano M.E., Martínez-Martínez L., et al. Impact of antibiotic resistance and of adequate empirical antibiotic treatment in the prognosis of patients with Escherichia coli bacteraemia. J Antimicrob Chemother 2007, 60:855-863.
20. Tumbarello M., Sanguinetti M., Montuori E., Trecarichi E.M., Posteraro B., Fiori B., et al. Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment. Antimicrob Agents Chemother 2007, 51:1987-1994.
21. Marschall J., Agniel D., Fraser V.J., Doherty J., Warren D.K. Gram-negative bacteraemia in non-ICU patients: factors associated with inadequate antibiotic therapy and impact on outcomes. J Antimicrob Chemother 2008, 61:1376-1383.
22. Chen H.C., Lin W.L., Lin C.C., Hsieh W.H., Hsieh W.H., Wu M.H., et al. Outcome of inadequate empirical antibiotic therapy in emergency department patients with community-onset bloodstream infections. J Antimicrob Chemother 2013, 68:947-953.
23. Vazquez-Guillamet C., Scolari M., Zilberberg M.D., Shorr A.F., Micek S.T., Kollef M. Using the number needed to treat to assess appropriate antimicrobial therapy as a determinant of outcome in severe sepsis and septic shock. Crit Care Med 2014, 42:2342-2349.
24. Hernandez C., Feher C., Soriano A., Marco F., Almela M., Cobos-Trigueros N., et al. Clinical characteristics and outcome of elderly patients with community-onset bacteremia. J Infect 2015, 70:135-143.
25. McGregor J.C., Rich S.E., Harris A.D., Perencevich E.N., Osih R., Lodise T.P., et al. A systematic review of the methods used to assess the association between appropriate antibiotic therapy and mortality in bacteremic patients. Clin Infect Dis 2007, 45:329-337.
26. Corona A., Bertolini G., Lipman J., Wilson A.P., Singer M. Antibiotic use and impact on outcome from bacteraemic critical illness: the BActeraemia Study in Intensive Care (BASIC). J Antimicrob Chemother 2010, 65:1276-1285.
27. Retamar P., Portillo M.M., López-Prieto M.D., Rodríguez-López F., de Cueto M., García M.V., et al. Impact of inadequate empirical therapy on the mortality of patients with bloodstream infections: a propensity score-based analysis. Antimicrob Agent Chemother 2012, 56:472-478.
28. Cain S.E., Kohn J., Bookstaver P.B., Albrecht H., Al-Hasan M.N. Stratification of the impact of inappropriate empirical antimicrobial therapy for gram-negative bloodstream infections by predicted prognosis. Antimicrob Agent Chemother 2015, 59:245-250.
29. McGinley A., Pearse R.M. A national early warning score for acutely ill patients. BMJ 2012, 345:e5310.
30. van Buuren S. Multiple imputation of discrete and continuous data by fully conditional specification. Stat Methods Med Res 2007, 16:219-242.