The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Daugherty, Daniel J ^a   Chechneva, Olga ^a   Mayrhofer, Florian ^b   Deng, Wenbin ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Institute for Pediatric Regenerative Medicine   (United States)

^c HUBEI UNIVERSITY OF ARTS AND SCIENCE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; BZRP PROTEIN, MOUSE; CXCL10 PROTEIN, MOUSE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIAL FIBRILLARY ASTROCYTIC PROTEIN, MOUSE; MESSENGER RNA; TUMOR NECROSIS FACTOR;

ANIMAL; C57BL MOUSE; CENTRAL NERVOUS SYSTEM; DISEASE MODEL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; MOUSE; MULTIPLE SCLEROSIS; PATHOLOGY; PROMOTER REGION;

ANIMALS; CENTRAL NERVOUS SYSTEM; CHEMOKINE CXCL10; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; INFLAMMATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPLE SCLEROSIS; PROMOTER REGIONS, GENETIC; RECEPTORS, GABA; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84959573495     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep22556     Document Type: Article

References (21)

1. Cosenza-Nashat, M. et al. Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain. Neuropathol. Appl. Neurobiol. 35, 306-328 (2009).
2. Yasuno, F. et al. Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106. Biol. Psych. 64, 835-841 (2008).
3. Meßmer, K. & Reynolds, G. P. Increased peripheral benzodiazepine binding sites in the brain of patients with Huntington's disease. Neurosci. Lett. 241, 53-56 (1998).
4. Gerhard, A., Schwarz, J., Myers, R., Wise, R. & Banati, R. B. Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study. NeuroImage 24, 591-595 (2005).
5. Papadopoulos, V. & Lecanu, L. Translocator protein (18 kDa) TSPO: An emerging therapeutic target in neurotrauma. Exp. Neurol. 219, 53-57 (2009).
6. Chen, M.-K. & Guilarte, T. R. Imaging the Peripheral Benzodiazepine Receptor Response in Central Nervous System Demyelination and Remyelination. Toxicol. Sci. 91, 532-539 (2006).
7. Hong, S. H., Choi, H. B., Kim, S. U. & McLarnon, J. G. Mitochondrial ligand inhibits store-operated calcium influx and COX-2 production in human microglia. J. Neurosci. Res. 83, 1293-1298 (2006).
8. Verleye, M. et al. The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain. Pharmacol. Biochem. Behav. 82, 712-720 (2005).
9. Zhuo, L. et al. hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis 31, 85-94 (2001).
10. Lo, U. et al. p38alpha (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes. Sci. Rep. 4, 7405; doi: 10.1038/srep07405 (2014).
11. Girard, C. et al. Etifoxine improves peripheral nerve regeneration and functional recovery. Proc. Natl. Acad. Sci. USA 105, 20505-20510 (2008).
12. Morohaku, K. et al. Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. Endocrinology 155, 89-97 (2013).
13. Šileikytė, J. et al. Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (translocator protein of 18 kDa (TSPO)). J. Biol. Chem. 289, 13769-13781 (2014).
14. Tu, L. N. et al. Peripheral benzodiazepine receptor/translocator protein global knockout mice are viable with no effects on steroid hormone biosynthesis. J. Biol. Chem. 289, 27444-27454 (2014).
15. Takano, A. et al. In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106. EJNMMI Res. 3, 30, doi: 10.1186/2191-219X-3-30 (2013).
16. Daugherty, D. J. et al. A TSPO ligand is protective in a mouse model of multiple sclerosis. EMBO Mol. Med. 5, 891-903 (2013).
17. Ryu, J. K., Choi, H. B. & McLarnon, J. G. Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum. Neurobiol. Dis. 20, 550-561 (2005).
18. Chung, I. Y. & Benveniste, E. N. Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide, IFNgamma and IL-1 beta. J. Immunol. 144, 2999-3007 (1990).
19. Choi, H. B. et al. Inhibition of lipopolysaccharide-induced cyclooxygenase-2, tumor necrosis factor-α and [Ca2+ ]i responses in human microglia by the peripheral benzodiazepine receptor ligand PK11195. J. Neurochem. 83, 546-555 (2002).
20. Phares, T. W., Stohlman, S. A., Hinton, D. R. & Bergmann, C. C. Astrocyte-Derived CXCL10 Drives Accumulation of Antibody-Secreting Cells in the Central Nervous System during Viral Encephalomyelitis. J. Virol. 87, 3382-3392 (2013).
21. Banati, R. B. et al. Positron emission tomography and functional characterization of a complete PBR/TSPO knockout. Nat. Commun. 5, 5452, doi: 10.1038/ncomms6452 (2014).