Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia

Journal of Thoracic and Cardiovascular Surgery

Volumn 151, Issue 1, 2016, Pages 245-252

  Sabe, Ashraf A ^a   Potz, Brittany A ^a   Elmadhun, Nassrene Y ^a   Liu, Yuhong ^a   Feng, Jun ^a   Abid, M Ruhul ^a   Abbott, Jinnette D ^a   Senger, Donald R ^b   Sellke, Frank W ^a  

^a BROWN UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

angiogenesis; animal model surgery; calpain inhibition; collateral circulation; ischemic heart disease; myocardial revascularization; perfusion

Indexed keywords

ANGIOPOIETIN 1; CALPAIN; ENDOSTATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; PAXILLIN; PHOSPHOPROTEIN; PHOSPHORYLATED EXTRACELLULAR SIGNAL REGULATED KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TALIN; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VINCULIN; [1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; ANGIOGENIC PROTEIN; PROTEINASE INHIBITOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY DENSITY; CHOLESTEROL DIET; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CIRCUMFLEX BRANCH; CORONARY ARTERY COLLATERAL CIRCULATION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; ENZYME INHIBITION; EXPERIMENTAL MYOCARDIAL ISCHEMIA; HEART MUSCLE PERFUSION; HEART MUSCLE RELAXATION; HEART PACING; HYPERCHOLESTEROLEMIA; LOW DRUG DOSE; MALE; MICROVASCULATURE; NONHUMAN; PORCINE MODEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REST; UPREGULATION; VASCULAR ENDOTHELIUM; YORKSHIRE PIG; ANIMAL; ANTAGONISTS AND INHIBITORS; CHRONIC DISEASE; COLLATERAL CIRCULATION; COMPLICATION; CORONARY ANGIOGRAPHY; CORONARY BLOOD VESSEL; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROCIRCULATION; MYOCARDIAL ISCHEMIA; MYOCARDIAL PERFUSION IMAGING; PATHOPHYSIOLOGY; TIME FACTOR; VASODILATATION;

ANGIOGENIC PROTEINS; ANIMALS; CALPAIN; CHRONIC DISEASE; COLLATERAL CIRCULATION; CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; CORONARY VESSELS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERCHOLESTEROLEMIA; MALE; MICROCIRCULATION; MICROVESSELS; MYOCARDIAL ISCHEMIA; MYOCARDIAL PERFUSION IMAGING; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEASE INHIBITORS; TIME FACTORS; VASODILATION;

EID: 84959559287     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2015.08.101     Document Type: Article

References (23)

1. A.D. Lassaletta, L.M. Chu, and F.W. Sellke Therapeutic neovascularization for coronary disease: current state and future prospects Basic Res Cardiol 106 2011 897 909
2. M.R. Bell, B.J. Gersh, H.V. Schaff, D.R. Holmes Jr., L.D. Fisher, E.L. Alderman, and et al. Effect of completeness of revascularization on long-term outcome of patients with three-vessel disease undergoing coronary artery bypass surgery. A report from the coronary artery surgery study (CASS) registry Circulation 86 1992 446 457
3. G.M. Lawrie, G.C. Morris Jr., A. Silvers, W.F. Wagner, A.E. Baron, S.S. Beltangady, and et al. The influence of residual disease after coronary bypass on the 5-year survival rate of 1274 men with coronary artery disease Circulation 66 1982 717 723
4. M. Boodhwani, N.R. Sodha, S. Mieno, S.H. Xu, J. Feng, B. Ramlawi, and et al. Functional, cellular, and molecular characterization of the angiogenic response to chronic myocardial ischemia in diabetes Circulation 116 2007 I31 I37
5. A. Abaci, A. Oguzhan, S. Kahraman, N.K. Eryol, S. Unal, H. Arinc, and et al. Effect of diabetes mellitus on formation of coronary collateral vessels Circulation 99 1999 2239 2242
6. S.J. Franco, and A. Huttenlocher Regulating cell migration: calpains make the cut J Cell Sci 118 2005 3829 3838
7. M.V. Hoang, J.A. Nagy, J.E. Fox, and D.R. Senger Moderation of calpain activity promotes neovascular integration and lumen formation during VEGF-induced pathological angiogenesis PLoS One 5 2010 e13612
8. M.V. Hoang, L.E. Smith, and D.R. Senger Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion Biochim Biophys Acta 1812 2011 549 557
9. E. Nakajima, L.L. David, C. Bystrom, T.R. Shearer, and M. Azuma Calpain-specific proteolysis in primate retina: contribution of calpains in cell death Invest Ophthalmol Vis Sci 47 2006 5469 5475
10. D.A. Potter, J.S. Tirnauer, R. Janssen, D.E. Croall, C.N. Hughes, K.A. Fiacco, and et al. Calpain regulates actin remodeling during cell spreading J Cell Biol 141 1998 647 662
11. M.P. Robich, R.M. Osipov, R. Nezafat, J. Feng, R.T. Clements, C. Bianchi, and et al. Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia Circulation 122 2010 S142 S149
12. K.P. Rentrop, M. Cohen, H. Blanke, and R.A. Phillips Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects J Am Coll Cardiol 5 1985 587 592
13. A.A. Sabe, N.Y. Elmadhun, A.A. Sadek, L.M. Chu, C. Bianchi, and F.W. Sellke Differential effects of atorvastatin on autophagy in ischemic and nonischemic myocardium in Ossabaw swine with metabolic syndrome J Thorac Cardiovasc Surg 148 2014 3172 3178
14. N.Y. Elmadhun, A.D. Lassaletta, L.M. Chu, Y. Liu, J. Feng, and F.W. Sellke Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome J Thorac Cardiovasc Surg 144 2012 1486 1493
15. N. Ferrara, H.P. Gerber, and J. LeCouter The biology of VEGF and its receptors Nat Med 9 2003 669 676
16. S.J. Franco, M.A. Rodgers, B.J. Perrin, J. Han, D.A. Bennin, D.R. Critchley, and et al. Calpain-mediated proteolysis of talin regulates adhesion dynamics Nat Cell Biol 6 2004 977 983
17. M. Kotecki, A.S. Zeiger, K.J. Van Vliet, and I.M. Herman Calpain- and talin-dependent control of microvascular pericyte contractility and cellular stiffness Microvasc Res 80 2010 339 348
18. H.A. Ahmad, L. Lu, S. Ye, G.G. Schwartz, and C.R. Greyson Calpain inhibition preserves talin and attenuates right heart failure in acute pulmonary hypertension Am J Respir Cell Mol Biol 47 2012 379 386
19. Y. Su, and E.R. Block Role of calpain in hypoxic inhibition of nitric oxide synthase activity in pulmonary endothelial cells Am J Physiol 278 2000 L1204 L1212
20. T.J. Stalker, C.B. Skvarka, and R. Scalia A novel role for calpains in the endothelial dysfunction of hyperglycemia FASEB J 17 2003 1511 1513
21. M.C. McDonald, H. Mota-Filipe, A. Paul, S. Cuzzocrea, M. Abdelrahman, S. Harwood, and et al. Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock FASEB J 15 2001 171 186
22. H. Ruetten, and C. Thiemermann Effect of calpain inhibitor I, an inhibitor of the proteolysis of I kappa B, on the circulatory failure and multiple organ dysfunction caused by endotoxin in the rat Br J Pharmacol 121 1997 695 704
23. B.A. Potz, A.A. Sabe, N.Y. Elmadhun, J. Feng, Y. Lui, H. Mitchell, and et al. Calpain inhibition decreases apoptosis in a swine model of chronic myocardial ischemia Surgery 158 2015 445 452