Identification of the appropriate dose metric for pulmonary inflammation of silver nanoparticles in an inhalation toxicity study

Nanotoxicology

Volumn 10, Issue 1, 2016, Pages 63-73

  Braakhuis, Hedwig M ^a,b   Cassee, Flemming R ^b,c   Fokkens, Paul H B ^b   De La Fonteyne, Liset J J ^b   Oomen, Agnes G ^b   Krystek, Petra ^d   De Jong, Wim H ^b   Van Loveren, Henk ^a,b   Park, Margriet V D Z ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d PHILIPS RESEARCH LABORATORIES   (Germany)

Author keywords

Dose metrics; inhalation exposure; nanotoxicology; risk assessment

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; SILVER NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; METAL NANOPARTICLE; SILVER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; CHEMICAL COMPOSITION; CONTROLLED STUDY; DOSE RESPONSE; DOSIMETRY; ENVIRONMENTAL EXPOSURE; HUMIDITY; INHALATIONAL DRUG ADMINISTRATION; LEUKOCYTE DIFFERENTIAL COUNT; LUNG BURDEN; LUNG CLEARANCE; LUNG TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PNEUMONIA; PREMATURE MORTALITY; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SURFACE AREA; ANIMAL; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; EXPOSURE; FISCHER 344 RAT; IMMUNOLOGY; LUNG; METABOLISM;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; INHALATION EXPOSURE; LUNG; MALE; METAL NANOPARTICLES; OXIDATIVE STRESS; PARTICLE SIZE; PNEUMONIA; RATS; RATS, INBRED F344; SILVER;

EID: 84959553835     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2015.1012184     Document Type: Article

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