Protective effect of Ad-VEGF-bone mesenchymal stem cells on cerebral infarction

Turkish Neurosurgery

Volumn 26, Issue 1, 2016, Pages 8-15

  Chen, Bo ^a   Zhang, Feng ^b   Li, Qiao Yu ^c   Gong, Aihua ^d   Lan, Qing ^a  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b 101 Hospital of Chinese People's Liberation Army Department of Neurosurgery   (China)

^c First People's Hospital of Zhenjiang   (China)

^d JIANGSU UNIVERSITY   (China)

Author keywords

Bone mesenchymal stem cell; Intracerebroventricular injection; Ischemic stroke; Phosphoinositide 3 kinase akt glycogen synthase kinase 3 pathway; Vascular endothelial growth factor

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; VASCULOTROPIN A;

ANIMAL; BRAIN; BRAIN ISCHEMIA; DISEASE MODEL; GENETICS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; NEUROPROTECTION; PATHOLOGY; PHYSIOLOGY; PROCEDURES; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; NEUROPROTECTION; PHOSPHATIDYLINOSITOL 3-KINASES; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84959543398     PISSN: 10195149     EISSN: None     Source Type: Journal    
DOI: 10.5137/1019-5149.JTN.11488-14.3     Document Type: Article

References (24)

1. Araujo M, Wandosell F: Differential cellular response after glutamate analog hippocampus damage. J Neurosci Res 44: 397-409, 1996
2. Benakis C, Bonny C, Hirt L: JNK inhibition and inflammation after cerebral ischemia. Brain Behav Immun 24:800-811, 2010
3. Bovolenta P, Wandosell F, Nieto-Sampedro M: CNS glial scar tissue: A source of molecules which inhibit central neurite outgrowth. Prog Brain Res 94:367-379, 1992
4. Chen J, Li Y, Wang L, Lu M, Zhang X, Chopp M: Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci 189:49-57, 2001
5. Chiba Y, Sasayama T, Miyake S, Koyama J, Kondoh T, Hosoda K, Kohmura E: Anti-VEGF receptor antagonist (VGA1155) reduces infarction in rat permanent focal brain ischemia. Kobe J Med Sci 54: E136-146, 2008
6. Connolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley BL, Delfino JJ, Siegel NR, Leimgruber RM, Feder J: Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84:1470-1478, 1989
7. Connolly DT, Olander JV, Heuvelman D, Nelson R, Monsell R, Siegel N, Haymore BL, Leimgruber R, Feder J: Human vascular permeability factor. Isolation from U937 cells. J Biol Chem 264:20017-20024, 1989
8. Endo H, Nito C, Kamada H, Nishi T, Chan PH: Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats. J Cereb Blood Flow Metab 26:1479-1489, 2006
9. Gao X, Zhang H, Takahashi T, Hsieh J, Liao J, Steinberg GK, Zhao H: The Akt signaling pathway contributes to postconditioning's protection against stroke; The protection is associated with the MAPK and PKC pathways. J Neurochem 105:943-955, 2008
10. Graham GD: Tissue plasminogen activator for acute ischemic stroke in clinical practice: A meta-analysis of safety data. Stroke 34: 2847-2850, 2003
11. Kilic E, Kilic U, Wang Y, Bassetti CL, Marti HH, Hermann DM: The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J 20:1185-1187, 2006
12. Kriz J: Inflammation in ischemic brain injury: Timing is important. Crit Rev Neurobiol 18(1-2): 145-157, 2006
13. Laurer HL, Mcintosh TK: Experimental models of brain trauma. Curr Opin Neurol 12(6): 715-721, 1999
14. Noshita N, Lewen A, Sugawara T, Chan PH: Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 21:1442-1450, 2001
15. Sarkar D, Zhao W, Gupta A, Loh WL, Karnik R, Karp JM: Cell surface engineering of mesenchymal stem cell. Methods Mol Biol 698:505-523, 2011
16. Schallert T, Kozlowski DA, Humm JL, Cocke RR: Use-dependent structural events in recovery of function. Adv Neurol 73:229-238, 1997
17. Seung-Wan Y, Sung-Soo K, Lee SY, Lee HS, Kim HS, Lee YD, Suh-Kim H: Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model. Exp Mol Med 40(4): 387-397, 2008
18. Sun B, Chen L, Wei X, Xiang Y, Liu X, Zhang X: The Akt/GSK-3beta pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats. Biochem Biophys Res Comm 409: 808-813, 2011
19. Towfighi A, Ovbiagele B, Saver JL: Therapeutic mile-stone: Stroke declines from the second to the third leading organ-and diseasespecific cause of death in the United States. Stroke 41:499-503, 2009
20. Wang H, Wang G, Yu Y, Wang Y: The role of phosphoinositide-3-kinase /Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. Brain Res 1297:177-184, 2009
21. Yip TR, Demaerschalk BM: Estimated cost savings of increased use of intravenous tissue plasminogen activator for acute ischemic stroke in Canada. Stroke 38: 1952-1955, 2007
22. Yuji K, Naoki T, Kazutaka S: Cell therapy for stroke: Emphasis on optimizing safety and efficacy profile of endothelial progenitor cells. Curr Pharm Des 18(25): 3731-3734, 2012
23. Zhang ZG, Zhang L, Jiang Q, Zhang R, Davies K, Powers C, Bruggen Nv, Chopp M: VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest 106:829-838, 2000
24. Zhao H, Sapolsky RM, Steinberg GK: Phosphoinositide-3-kinase/ akt survival signal pathways are implicated in neuronal survival after stroke. Mol Neurobiol 34:249-270, 2006