Reprogramming psychiatry: Stem cells and bipolar disorder

The Lancet

Volumn 387, Issue 10021, 2016, Pages 823-825

  Harrison, Paul J ^a   Cader, M Zameel ^b   Geddes, John R ^a  

^a WARNEFORD HOSPITAL   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LITHIUM; SODIUM CHANNEL; LITHIUM DERIVATIVE; NEUROLEPTIC AGENT;

ACTION POTENTIAL; AUTISM; BIPOLAR DISORDER; CALCIUM SIGNALING; CELL REPROGRAMMING TECHNIQUE; HUMAN; NOTE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PSYCHIATRY; SCHIZOPHRENIA; STEM CELL TRANSPLANTATION; TREATMENT RESPONSE; DRUG EFFECTS; MALE; NERVE CELL; PATHOLOGY;

ACTION POTENTIALS; ANTIPSYCHOTIC AGENTS; BIPOLAR DISORDER; HUMANS; LITHIUM COMPOUNDS; MALE; NEURONS;

EID: 84959511538     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(16)00235-X     Document Type: Note

References (14)

1. T Kaiser, G Feng Modeling psychiatric disorders for developing effective treatments Nat Med 21 2015 979 988
2. KJ Brennand, A Simone, J Jou et al. Modelling schizophrenia using human induced pluripotent stem cells Nature 473 2011 221 225
3. J Mariani, G Coppola, P Zhang et al. FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders Cell 162 2015 375 390
4. HM Chen, CJ DeLong, M Bame et al. Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients Transl Psychiatry 4 2014 e375
5. JM Madison, F Zhou, A Nigam et al. Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities Mol Psychiatry 20 2015 703 717
6. JL Wang, SM Shamah, AX Sun et al. Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness Transl Psychiatry 4 2014 e428
7. J Mertens, QW Wang, Y Kim et al. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder Nature 527 2015 95 99
8. AC Andreazza, LT Young The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment Int J Neuropsychopharmacol 17 2014 1039 1052
9. PJ Harrison Molecular neurobiological clues to the pathogenesis of bipolar disorder Curr Opin Neurobiol 36 2016 1 6
10. M Alda Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics Mol Psychiatry 20 2015 661 670
11. TL Young-Pearse, EM Morrow Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities Curr Opin Neurobiol 36 2016 66 73
12. T Yoshimizu, JQ Pan, AE Mungenast et al. Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons Mol Psychiatry 20 2015 162 169
13. AE Handel, S Chintawar, T Lalic et al. Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics Hum Mol Genet 2016 10.1093/hmg/ddv637 published online Jan 5.
14. MA Lancaster, M Renner, C-A Martin et al. Cerebral organoids model human brain development and microcephaly Nature 501 2013 373 379