Chronic Alcohol Consumption Causes Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response

Alcoholism: Clinical and Experimental Research

Volumn 40, Issue 3, 2016, Pages 518-528

  Song, Ming ^a   Chen, Theresa ^a   Prough, Russell A ^a   Cave, Matthew C ^a,b   Mcclain, Craig J ^a,b  

^a University of Louisville School of Medicine   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alcohol; Fructose; Kupffer Cell Activation; M1 Polarization; Nonalcoholic Fatty Liver Disease

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COPPER; ENDOTOXIN; FRUCTOSE; LIPOPOLYSACCHARIDE BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ALCOHOL METABOLISM; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CD163 GENE; CD38 GENE; CONTROLLED STUDY; DIETARY INTAKE; DISEASE COURSE; DISEASE EXACERBATION; EMR1 GENE; EPIDIDYMIS FAT; FATTY LIVER; FRUCTOSE METABOLISM; GENE; GENE EXPRESSION; INFLAMMATION; KUPFFER CELL; LIPID STORAGE; LIVER INJURY; LIVER WEIGHT; MALE; MONOCYTE CHEMOATTRACTANT PROTEIN 1 GENE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEATOSIS; TOLL LIKE RECEPTOR 4 GENE; TUMOR NECROSIS FACTOR ALPHA GENE; UPREGULATION; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DRINKING BEHAVIOR; METABOLIC SYNDROME X; METABOLISM;

ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; FATTY LIVER; FRUCTOSE; LIVER DISEASES, ALCOHOLIC; MALE; METABOLIC SYNDROME X; MICE; MICE, INBRED C57BL;

EID: 84959510424     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12994     Document Type: Article

References (50)

1. Aigner E, Strasser M, Haufe H, Sonnweber T, Hohla F, Stadlmayr A, Solioz M, Tilg H, Patsch W, Weiss G, Stickel F, Datz C (2010) A role for low hepatic copper concentrations in nonalcoholic Fatty liver disease. Am J Gastroenterol 105:1978-1985.
2. Aigner E, Theurl I, Haufe H, Seifert M, Hohla F, Scharinger L, Stickel F, Mourlane F, Weiss G, Datz C (2008) Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease. Gastroenterology 135:680-688.
3. Alwahsh SM, Xu M, Schultze FC, Wilting J, Mihm S, Raddatz D, Ramadori G (2014) Combination of alcohol and fructose exacerbates metabolic imbalance in terms of hepatic damage, dyslipidemia, and insulin resistance in rats. PLoS One 9:e104220.
4. Arteel GE (2003) Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 124:778-790.
5. Assy N, Nasser G, Kamayse I, Nseir W, Beniashvili Z, Djibre A, Grosovski M (2008) Soft drink consumption linked with fatty liver in the absence of traditional risk factors. Can J Gastroenterol 22:811-816.
6. Bagchi A, Herrup EA, Warren HS, Trigilio J, Shin HS, Valentine C, Hellman J (2007) MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J Immunol 178:1164-1171.
7. Bergheim I, Weber S, Vos M, Kramer S, Volynets V, Kaserouni S, McClain CJ, Bischoff SC (2008) Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. J Hepatol 48:983-992.
8. Bjarnason I, Peters TJ, Wise RJ (1984) The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1:179-182.
9. Blank SE, Duncan DA, Meadows GG (1991) Suppression of natural killer cell activity by ethanol consumption and food restriction. Alcohol Clin Exp Res 15:16-22.
10. Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917.
11. Carr RM, Correnti J (2015) Insulin resistance in clinical and experimental alcoholic liver disease. Ann N Y Acad Sci 1353:1-20.
12. Chiang DJ, McCullough AJ (2014) The impact of obesity and metabolic syndrome on alcoholic liver disease. Clin Liver Dis 18:157-163.
13. Deering TB, Dickson ER, Fleming CR, Geall MG, McCall JT, Baggenstoss AH (1977) Effect of D-penicillamine on copper retention in patients with primary billiary cirrhosis. Gastroenterology 72:1208-1212.
14. Fields M, Lewis CG, Lure MD (1994) Alcohol consumption mimics the effects of a high-fructose, low-copper diet in rats. Alcohol 11:17-23.
15. Fujisawa T, Riby J, Kretchmer N (1991) Intestinal absorption of fructose in the rat. Gastroenterology 101:360-367.
16. Gao B, Bataller R (2011) Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141:1572-1585.
17. Hallfrisch J (1990) Metabolic effects of dietary fructose. FASEB J 4:2652-2660.
18. Hritz I, Mandrekar P, Velayudham A, Catalano D, Dolganiuc A, Kodys K, Kurt-Jones E, Szabo G (2008) The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 48:1224-1231.
19. Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ (2002) Mechanisms of hepatotoxicity. Toxicol Sci 65:166-176.
20. Lee MJ, Bagci P, Kong J, Vos MB, Sharma P, Kalb B, Saltz JH, Martin DR, Adsay NV, Farris AB (2013) Liver steatosis assessment: correlations among pathology, radiology, clinical data and automated image analysis software. Pathol Res Pract 209:371-379.
21. Louvet A, Teixeira-Clerc F, Chobert MN, Deveaux V, Pavoine C, Zimmer A, Pecker F, Mallat A, Lotersztajn S (2011) Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology 54:1217-1226.
22. Luza SC, Speisky HC (1996) Liver copper storage and transport during development: implications for cytotoxicity. Am J Clin Nutr 63:812s-820s.
23. Meyerholz DK, Edsen-Moore M, McGill J, Coleman RA, Cook RT, Legge KL (2008) Chronic alcohol consumption increases the severity of murine influenza virus infections. J Immunol 181:641-648.
24. Minter RM, Bi X, Ben-Josef G, Wang T, Hu B, Arbabi S, Hemmila MR, Wang SC, Remick DG, Su GL (2009) LPS-binding protein mediates LPS-induced liver injury and mortality in the setting of biliary obstruction. Am J Physiol Gastrointest Liver Physiol 296:G45-G54.
25. Miura K, Yang L, Van Rooijen N, Ohnishi H, Seki E (2012) Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol 302:G1310-G1321.
26. Munford RS (2005) Detoxifying endotoxin: time, place and person. J Endotoxin Res 11:69-84.
27. Naveau S, Giraud V, Borotto E, Aubert A, Capron F, Chaput JC (1997) Excess weight risk factor for alcoholic liver disease. Hepatology 25:108-111.
28. Odermatt A (2011) The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease. Am J Physiol Renal Physiol 301:F919-F931.
29. Oleszczuk A, Spannbauer M, Tannapfel A, Bluher M, Hengstler J, Pietsch UC, Schuhmacher A, Wittekind C, Hauss JP, Schon MR (2007) Regenerative capacity differs between micro- and macrovesicular hepatic steatosis. Exp Toxicol Pathol 59:205-213.
30. Ouyang X, Cirillo P, Sautin Y, McCall S, Bruchette JL, Diehl AM, Johnson RJ, Abdelmalek MF (2008) Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol 48:993-999.
31. Parlesak A, Schafer C, Schutz T, Bode JC, Bode C (2000) Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease. J Hepatol 32:742-747.
32. Petrasek J, Dolganiuc A, Csak T, Nath B, Hritz I, Kodys K, Catalano D, Kurt-Jones E, Mandrekar P, Szabo G (2011) Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells. Hepatology 53:649-660.
33. Riby JE, Fujisawa T, Kretchmer N (1993) Fructose absorption. Am J Clin Nutr 58:748S-753S.
34. Rodriguez-Moreno F, Gonzalez-Reimers E, Santolaria-Fernandez F, Galindo-Martin L, Hernandez-Torres O, Batista-Lopez N, Molina-Perez M (1997) Zinc, copper, manganese, and iron in chronic alcoholic liver disease. Alcohol 14:39-44.
35. Roulot D, Costes JL, Buyck JF, Warzocha U, Gambier N, Czernichow S, Le Clesiau H, Beaugrand M (2011) Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years. Gut 60:977-984.
36. Schosinsky KH, Lehmann HP, Beeler MF (1974) Measurement of ceruloplasmin from its oxidase activity in serum by use of o-dianisidine dihydrochloride. Clin Chem 20:1556-1563.
37. Seki E, Brenner DA (2008) Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 48:322-335.
38. Song K, Coleman RA, Zhu X, Alber C, Ballas ZK, Waldschmidt TJ, Cook RT (2002) Chronic ethanol consumption by mice results in activated splenic T cells. J Leukoc Biol 72:1109-1116.
39. Song M, Schuschke DA, Zhou Z, Chen T, Pierce WM Jr, Wang R, Johnson WT, McClain CJ (2012) High fructose feeding induces copper deficiency in Sprague-Dawley rats: a novel mechanism for obesity related fatty liver. J Hepatol 56:433-440.
40. Song M, Zhou Z, Chen T, Zhang J, McClain CJ (2011) Copper deficiency exacerbates bile duct ligation-induced liver injury and fibrosis in rats. J Pharmacol Exp Ther 339:298-306.
41. Spruss A, Bergheim I (2009) Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease. J Nutr Biochem 20:657-662.
42. Spruss A, Kanuri G, Wagnerberger S, Haub S, Bischoff SC, Bergheim I (2009) Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology 50:1094-1104.
43. Stepanova M, Rafiq N, Younossi ZM (2010) Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: a population-based study. Gut 59:1410-1415.
44. Thurman RG (1998) II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol 275:G605-G611.
45. Tsukamoto H, Machida K, Dynnyk A, Mkrtchyan H (2009) "Second hit" models of alcoholic liver disease. Semin Liver Dis 29:178-187.
46. Uhlikova E, Kupcova V, Szantova M, Turecky L (2008) Plasma copper and ceruloplasmin in patients with alcoholic liver steatosis. Bratisl Lek Listy 109:431-433.
47. Wan J, Benkdane M, Teixeira-Clerc F, Bonnafous S, Louvet A, Lafdil F, Pecker F, Tran A, Gual P, Mallat A, Lotersztajn S, Pavoine C (2014) M2 Kupffer cells promote M1 Kupffer cell apoptosis: a protective mechanism against alcoholic and nonalcoholic fatty liver disease. Hepatology 59:130-142.
48. Wu D, Cederbaum AI (2009) Oxidative stress and alcoholic liver disease. Semin Liver Dis 29:141-154.
49. Xu J, Lai KK, Verlinsky A, Lugea A, French SW, Cooper MP, Ji C, Tsukamoto H (2011) Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol 55:673-682.
50. Zhong W, McClain CJ, Cave M, Kang YJ, Zhou Z (2010) The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. Am J Physiol Gastrointest Liver Physiol 298:G625-G633.