Connective tissue diseases: Mitochondria drive NETosis and inflammation in SLE

Nature Reviews Rheumatology

Volumn 12, Issue 4, 2016, Pages 195-196

  Boilard, Eric ^a   Fortin, Paul R ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; INTERFERON; MITOCHONDRIAL DNA; MYELOID DIFFERENTIATION FACTOR 88; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ADAPTIVE IMMUNITY; ANTIGEN ANTIBODY COMPLEX; ANTIPHOSPHOLIPID SYNDROME; CELL DEATH; CHRONIC GRANULOMATOUS DISEASE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; EXTRACELLULAR TRAP; GRANULOCYTE; HUMAN; INFLAMMATION; INNATE IMMUNITY; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NETOSIS; NEUTROPHIL; NONHUMAN; NOTE; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; FEMALE; IMMUNOLOGY; MALE; METABOLISM;

ANIMALS; DNA, MITOCHONDRIAL; EXTRACELLULAR TRAPS; FEMALE; GRANULOMATOUS DISEASE, CHRONIC; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MITOCHONDRIA; NEUTROPHILS;

EID: 84959507658     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2016.24     Document Type: Note

References (10)

1. Phillipson, M. & Kubes, P. The neutrophil in vascular inflammation. Nat. Med. 17, 1381-1390 (2011).
2. Villanueva, E. et al. Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J. Immunol. 187, 538-552 (2011).
3. Kaplan, M. J. Neutrophils in the pathogenesis and manifestations of SLE. Nat. Rev. Rheumatol. 7, 691-699 (2011).
4. Lood, C. et al. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Nat. Med. 22, 146-153 (2016).
5. Remijsen, Q. et al. Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res. 21, 290-304 (2011).
6. Bianchi, M. et al. Restoration of NET formation by gene therapy in CGD controls aspergillosis. Blood 114, 2619-2622 (2009).
7. Douda, D. N., Khan, M. A., Grasemann, H. & Palaniyar, N. SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx. Proc. Natl Acad. Sci. USA 112, 2817-2822 (2015).
8. Andersson, S. G. et al. The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature 396, 133-140 (1998).
9. Boudreau, L. H. et al. Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. Blood 124, 2173-2183 (2014).
10. Zhang, Q. et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464, 104-107 (2010).