Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

Nature Medicine

Volumn 22, Issue 2, 2016, Pages 146-153

  Lood, Christian ^a   Blanco, Luz P ^b   Purmalek, Monica M ^b   Carmona Rivera, Carmelo ^b   De Ravin, Suk S ^c   Smith, Carolyne K ^b   Malech, Harry L ^c   Ledbetter, Jeffrey A ^d   Elkon, Keith B ^a,d   Kaplan, Mariana J ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; INTERFERON; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RIBONUCLEOPROTEIN; ANTIGEN ANTIBODY COMPLEX; PEROXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CHRONIC GRANULOMATOUS DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; EXPERIMENTAL MODEL; EXTRACELLULAR TRAP; FEMALE; GRANULOCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRION; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; ADULT; ANIMAL; FLUORESCENCE MICROSCOPY; GENETICS; IMMUNOLOGY; IMMUNOPRECIPITATION; JURKAT CELL LINE; KIDNEY; METABOLISM; OXIDATION REDUCTION REACTION; REAL TIME POLYMERASE CHAIN REACTION;

ADULT; ANIMALS; ANTIGEN-ANTIBODY COMPLEX; DNA, MITOCHONDRIAL; EXTRACELLULAR TRAPS; FEMALE; GRANULOMATOUS DISEASE, CHRONIC; HUMANS; IMMUNOPRECIPITATION; IN VITRO TECHNIQUES; INTERFERON TYPE I; JURKAT CELLS; KIDNEY; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MICE; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; NADPH OXIDASE; NEUTROPHILS; OXIDATION-REDUCTION; PEROXIDASE; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RIBONUCLEOPROTEINS;

EID: 84957441476     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4027     Document Type: Article

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