Lactobacillus acidophilus attenuates Salmonella-induced intestinal inflammation via TGF-β signaling

BMC Microbiology

Volumn 15, Issue 1, 2015, Pages

  Huang, I Fei ^a,b,c   Lin, I Chun ^d   Liu, Pei Feng ^a   Cheng, Ming Fang ^a,b   Liu, Yen Chen ^a   Hsieh, Yao Dung ^a   Chen, Jih Jung ^e   Chen, Chun Lin ^f   Chang, Hsueh Wei ^g   Shu, Chih Wen ^a  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^d KAOHSIUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^e TAJEN UNIVERSITY   (Taiwan)

^f NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^g KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

L. acidophilus; MIR21; NF B; Salmonella; SMAD; Synbiotics; TGF b

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; INULIN; MICRORNA 21; PROBIOTIC AGENT; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; IMMUNOSUPPRESSIVE AGENT; SMAD3 PROTEIN, HUMAN; SMAD4 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CACO 2 CELL LINE; CONTROLLED STUDY; ENTERITIS; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INTRACELLULAR SIGNALING; LACTOBACILLUS ACIDOPHILUS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SALMONELLOSIS; TRANSCRIPTION REGULATION; BIOLOGICAL MODEL; BIOSYNTHESIS; CACO-2 CELL LINE; GENE EXPRESSION PROFILING; GROWTH, DEVELOPMENT AND AGING; INFLAMMATION; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

CACO-2 CELLS; CYTOKINES; GENE EXPRESSION PROFILING; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; INULIN; LACTOBACILLUS ACIDOPHILUS; MODELS, BIOLOGICAL; NF-KAPPA B; PROBIOTICS; REAL-TIME POLYMERASE CHAIN REACTION; SALMONELLA INFECTIONS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84959499462     PISSN: None     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/s12866-015-0546-x     Document Type: Article

References (37)

1. Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA. 2004;101(44):15718-23.
2. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027-31.
3. Mundy R, MacDonald TT, Dougan G, Frankel G, Wiles S. Citrobacter rodentium of mice and man. Cell Microbiol. 2005;7(12):1697-706.
4. Schiller LR. Infectious disease: A germy world-food-borne infections in 2009. Nat Rev Gastroenterol Hepatol. 2009;6(4):197-8.
5. Abrahams GL, Muller P, Hensel M. Functional dissection of SseF, a type III effector protein involved in positioning the salmonella-containing vacuole. Traffic. 2006;7(8):950-65.
6. Gewirtz AT, Rao AS, Simon Jr PO, Merlin D, Carnes D, Madara JL, et al. Salmonella typhimurium induces epithelial IL-8 expression via Ca(2+)-mediated activation of the NF-kappaB pathway. J Clin Invest. 2000;105(1):79-92.
7. Kim MS, Yoon YS, Seo JG, Lee HG, Chung MJ, Yum DY. A study on the prevention of salmonella infection by using the aggregation characteristics of lactic Acid bacteria. Toxicol Res. 2013;29(2):129-35.
8. Brown SP, Le Chat L, Taddei F. Evolution of virulence: Triggering host inflammation allows invading pathogens to exclude competitors. Ecol Lett. 2008;11(1):44-51.
9. Yang YJ, Chuang CC, Yang HB, Lu CC, Sheu BS. Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFkappaB pathways. BMC Microbiol. 2012;12:38.
10. McCabe LR, Irwin R, Schaefer L, Britton RA. Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice. J Cell Physiol. 2013;228(8):1793-8.
11. Dimitrijevic R, Ivanovic N, Mathiesen G, Petrusic V, Zivkovic I, Djordjevic B, et al. Effects of Lactobacillus rhamnosus LA68 on the immune system of C57BL/6 mice upon oral administration. J Dairy Res. 2014;81(2):202-7.
12. Ivanovic N, Minic R, Dimitrijevic L, Radojevic Skodric S, Zivkovic I, Djordjevic B. Lactobacillus rhamnosus LA68 and Lactobacillus plantarum WCFS1 differently influence metabolic and immunological parameters in high fat diet-induced hypercholesterolemia and hepatic steatosis. Food Funct. 2015;6(2):558-65.
13. Li C, Nie SP, Zhu KX, Ding Q, Li C, Xiong T, et al. Lactobacillus plantarum NCU116 improves liver function, oxidative stress and lipid metabolism in rats with high fat diet induced non-alcoholic fatty liver disease. Food Funct. 2014;5(12):3216-23.
14. Chiu YH, Lu YC, Ou CC, Lin SL, Tsai CC, Huang CT, et al. Lactobacillus plantarum MYL26 induces endotoxin tolerance phenotype in Caco-2 cells. BMC Microbiol. 2013;13:190.
15. Chiu YH, Lin SL, Tsai JJ, Lin MY. Probiotic actions on diseases: Implications for therapeutic treatments. Food Funct. 2014;5(4):625-34.
16. Monteleone G, Pallone F, MacDonald TT. Smad7 in TGF-beta-mediated negative regulation of gut inflammation. Trends Immunol. 2004;25(10):513-7.
17. Bitzer M, von Gersdorff G, Liang D, Dominguez-Rosales A, Beg AA, Rojkind M, et al. A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA. Genes Dev. 2000;14(2):187-97.
18. Foye OT, Huang IF, Chiou CC, Walker WA, Shi HN. Early administration of probiotic Lactobacillus acidophilus and/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7 cell signaling. FEMS Immunol Med Microbiol. 2012;65(3):467-80.
19. Li Q, Zhang D, Wang Y, Sun P, Hou X, Larner J, et al. MiR-21/Smad 7 signaling determines TGF-beta1-induced CAF formation. Sci Rep. 2013;3:2038.
20. Wang T, Zhang L, Shi C, Sun H, Wang J, Li R, et al. TGF-beta-induced miR-21 negatively regulates the antiproliferative activity but has no effect on EMT of TGF-beta in HaCaT cells. Int J Biochem Cell Biol. 2012;44(2):366-76.
21. Kim YJ, Hwang SJ, Bae YC, Jung JS. MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue. Stem cells (Dayton, Ohio). 2009;27(12):3093-102.
22. Dong J, Jimi E, Zeiss C, Hayden MS, Ghosh S. Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease. Genes Dev. 2010;24(16):1709-17.
23. Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M. Multiple control of interleukin-8 gene expression. J Leukoc Biol. 2002;72(5):847-55.
24. Karimi R, Azizi MH, Ghasemlou M, Vaziri M. Application of inulin in cheese as prebiotic, fat replacer and texturizer: A review. Carbohydr Polym. 2015;119C:85-100.
25. Godinez I, Raffatellu M, Chu H, Paixao TA, Haneda T, Santos RL, et al. Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestine. Infect Immun. 2009;77(1):387-98.
26. Malago JJ, Nemeth E, Koninkx JF, Tooten PC, Fajdiga S, van Dijk JE. Microbial products from probiotic bacteria inhibit Salmonella enteritidis 857-induced IL-8 synthesis in Caco-2 cells. Folia Microbiol (Praha). 2010;55(4):401-8.
27. Bested AC, Logan AC, Selhub EM. Intestinal microbiota, probiotics and mental health: From Metchnikoff to modern advances: Part I-autointoxication revisited. Gut Pathog. 2013;5(1):5.
28. Monteleone G, Fantini MC, Onali S, Zorzi F, Sancesario G, Bernardini S, et al. Phase I clinical trial of Smad7 knockdown using antisense oligonucleotide in patients with active Crohn's disease. Mol Ther. 2012;20(4):870-6.
29. Roberfroid M. Prebiotics: The concept revisited. J Nutr. 2007;137(3 Suppl 2):830S-7S.
30. Scholz-Ahrens KE, Ade P, Marten B, Weber P, Timm W, Acil Y, et al. Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure. J Nutr. 2007;137(3 Suppl 2):838S-46S.
31. Lomax AR, Calder PC. Prebiotics, immune function, infection and inflammation: A review of the evidence. Br J Nutr. 2009;101(5):633-58.
32. Geier MS, Butler RN, Howarth GS. Inflammatory bowel disease: Current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics. Int J Food Microbiol. 2007;115(1):1-11.
33. Hedin C, Whelan K, Lindsay JO. Evidence for the use of probiotics and prebiotics in inflammatory bowel disease: A review of clinical trials. Proc Nutr Soc. 2007;66(3):307-15.
34. Zenhom M, Hyder A, de Vrese M, Heller KJ, Roeder T, Schrezenmeir J. Prebiotic oligosaccharides reduce proinflammatory cytokines in intestinal Caco-2 cells via activation of PPARgamma and peptidoglycan recognition protein 3. J Nutr. 2011;141(5):971-7.
35. Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: A meta-analysis of masked, randomised, placebo-controlled trials. Lancet Infect Dis. 2006;6(6):374-82.
36. Lin JS, Chiu YH, Lin NT, Chu CH, Huang KC, Liao KW, et al. Different effects of probiotic species/strains on infections in preschool children: A double-blind, randomized, controlled study. Vaccine. 2009;27(7):1073-9.
37. Lin HC, Hsu CH, Chen HL, Chung MY, Hsu JF, Lien RI, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: A multicenter, randomized, controlled trial. Pediatrics. 2008;122(4):693-700.