메뉴 건너뛰기




Volumn 35, Issue 7, 2016, Pages 966-977

Mastering variation: Variance components and personalised medicine

Author keywords

Components of variation; Cross over trials; N of 1 trials; Personalised medicine; Random effects

Indexed keywords

ARTICLE; ASTHMA; CLINICAL PRACTICE; FORCED EXPIRATORY VOLUME; GENETIC VARIABILITY; HEALTH CARE POLICY; HUMAN; MEDICAL DECISION MAKING; METHODOLOGY; PERSONALIZED MEDICINE; STUDY DESIGN; TONSILLECTOMY; TREATMENT RESPONSE; VARIANCE; ANALYSIS OF VARIANCE; BIOSTATISTICS; CLINICAL TRIAL (TOPIC); COMPUTER GRAPHICS; COMPUTER SIMULATION; CROSSOVER PROCEDURE; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC); STATISTICS AND NUMERICAL DATA; UTILIZATION;

EID: 84959474251     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.6739     Document Type: Article
Times cited : (138)

References (54)
  • 2
    • 0035739148 scopus 로고    scopus 로고
    • Individual therapy: New dawn or false dawn
    • Senn SJ. Individual therapy: New dawn or false dawn. Drug Information Journal 2001; 35:1479-1494.
    • (2001) Drug Information Journal , vol.35 , pp. 1479-1494
    • Senn, S.J.1
  • 3
    • 6944230023 scopus 로고    scopus 로고
    • Individual response to treatment: is it a valid assumption?
    • Senn SJ. Individual response to treatment: is it a valid assumption? British Medical Journal 2004; 329:966-968.
    • (2004) British Medical Journal , vol.329 , pp. 966-968
    • Senn, S.J.1
  • 5
    • 0027398823 scopus 로고
    • Suspended judgment n-of-1 trials
    • Senn SJ. Suspended judgment n-of-1 trials. Controlled Clinical Trials 1993; 14:1-5.
    • (1993) Controlled Clinical Trials , vol.14 , pp. 1-5
    • Senn, S.J.1
  • 6
    • 0031826288 scopus 로고    scopus 로고
    • Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug research
    • Kalow W, Tang BK, Endrenyi L. Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug research. Pharmacogenetics 1998; 8:283-289.
    • (1998) Pharmacogenetics , vol.8 , pp. 283-289
    • Kalow, W.1    Tang, B.K.2    Endrenyi, L.3
  • 7
    • 84959572358 scopus 로고    scopus 로고
    • Paving the way for personalized medicine: FDA's role in a new era of medical product development
    • Food and Drug Administration. . In, U.S. Department of Health and Human Services (ed). Food and Drug Administration, Silver Spring, MD: City
    • Food and Drug Administration. Paving the way for personalized medicine: FDA's role in a new era of medical product development. In Paving the Way for Personalized Medicine: FDA's Role in a New Era of Medical Product Development, U.S. Department of Health and Human Services (ed). Food and Drug Administration, Silver Spring, MD: City, 2013.
    • (2013) Paving the Way for Personalized Medicine: FDA's Role in a New Era of Medical Product Development
  • 8
    • 85019520992 scopus 로고    scopus 로고
    • Cancer Research UK,Date accessed 3 May 2015
    • Cancer Research UK, http://www.cancerresearchuk.org/cancer-info/cancerstats/types/ Date accessed 3 May 2015
  • 10
    • 0038572263 scopus 로고    scopus 로고
    • Physicians' Desk Reference., Medical Economics (ed). Medical Economics Company: Montvale, NJ
    • Physicians' Desk Reference. Physicians' Desk Reference, Medical Economics (ed). Medical Economics Company: Montvale, NJ, 2000.
    • (2000) Physicians' Desk Reference
  • 11
    • 84901853551 scopus 로고    scopus 로고
    • A note regarding 'random effects'
    • Senn S. A note regarding 'random effects'. Statistics in Medicine 2014; 33:2876-2877.
    • (2014) Statistics in Medicine , vol.33 , pp. 2876-2877
    • Senn, S.1
  • 13
    • 0035865989 scopus 로고    scopus 로고
    • Cluster trials in implementation research: estimation of intracluster correlation coefficients and sample size
    • Campbell MK, Mollison J, Grimshaw JM. Cluster trials in implementation research: estimation of intracluster correlation coefficients and sample size. Statistics in Medicine 2001; 20:391-399.
    • (2001) Statistics in Medicine , vol.20 , pp. 391-399
    • Campbell, M.K.1    Mollison, J.2    Grimshaw, J.M.3
  • 14
    • 0023025908 scopus 로고
    • Analysis of data from multiclinic trials
    • Fleiss JL. Analysis of data from multiclinic trials. Controlled Clinical Trials 1986; 7:267-275.
    • (1986) Controlled Clinical Trials , vol.7 , pp. 267-275
    • Fleiss, J.L.1
  • 15
    • 0023498488 scopus 로고
    • Analysis of data from multiclinic trials
    • Grizzle JE. Analysis of data from multiclinic trials. Controlled Clinical Trials 1987; 8:392-393.
    • (1987) Controlled Clinical Trials , vol.8 , pp. 392-393
    • Grizzle, J.E.1
  • 16
    • 0032528888 scopus 로고    scopus 로고
    • A comparison of various estimators of a treatment difference for a multi-centre clinical trial
    • discussion 1799-1800.
    • Jones B, Teather D, Wang J, Lewis JA. A comparison of various estimators of a treatment difference for a multi-centre clinical trial. Statistics in Medicine 1998; 17:1767-1777 discussion 1799-1800.
    • (1998) Statistics in Medicine , vol.17 , pp. 1767-1777
    • Jones, B.1    Teather, D.2    Wang, J.3    Lewis, J.A.4
  • 17
    • 0032529143 scopus 로고    scopus 로고
    • Some controversies in planning and analysing multi-centre trials
    • discussion 1799-1800.
    • Senn SJ. Some controversies in planning and analysing multi-centre trials. Statistics in Medicine 1998; 17:1753-1765; discussion 1799-1800.
    • (1998) Statistics in Medicine , vol.17 , pp. 1753-1765
    • Senn, S.J.1
  • 18
    • 0033818505 scopus 로고    scopus 로고
    • Center-weighting issues in multicenter clinical trials
    • Gallo P. Center-weighting issues in multicenter clinical trials. Journal of biopharmaceutical statistics 2001; 10:145-163.
    • (2001) Journal of biopharmaceutical statistics , vol.10 , pp. 145-163
    • Gallo, P.1
  • 20
    • 0025796963 scopus 로고
    • Clinical usefulness of amitriptyline in fibromyalgia: the results of 23N-of-1 randomized controlled trials
    • Jaeschke R, Adachi J, Guyatt G, Keller J, Wong B. Clinical usefulness of amitriptyline in fibromyalgia: the results of 23N-of-1 randomized controlled trials. The Journal of rheumatology 1991; 18:447-451.
    • (1991) The Journal of rheumatology , vol.18 , pp. 447-451
    • Jaeschke, R.1    Adachi, J.2    Guyatt, G.3    Keller, J.4    Wong, B.5
  • 24
    • 40649099422 scopus 로고
    • T is for trouble (and textbooks): a critique of some examples of the paired-samples t-test
    • Preece DA. T is for trouble (and textbooks): a critique of some examples of the paired-samples t-test. The Statistician 1982; 31:169-195.
    • (1982) The Statistician , vol.31 , pp. 169-195
    • Preece, D.A.1
  • 27
    • 0345399126 scopus 로고
    • The probable error of a mean
    • Student.
    • Student. The probable error of a mean. Biometrika 1908; 6:1-25.
    • (1908) Biometrika , vol.6 , pp. 1-25
  • 28
    • 84555192592 scopus 로고    scopus 로고
    • Investigating variability in patient response to treatment - a case study from a replicate cross-over study
    • Senn S, Rolfe K, Julious SA. Investigating variability in patient response to treatment - a case study from a replicate cross-over study. Statistical Methods in Medical Research 2011; 20:657-666.
    • (2011) Statistical Methods in Medical Research , vol.20 , pp. 657-666
    • Senn, S.1    Rolfe, K.2    Julious, S.A.3
  • 30
    • 84928789447 scopus 로고    scopus 로고
    • Personalized medicine: time for one-person trials
    • Schork NJ. Personalized medicine: time for one-person trials. Nature 2015; 520:609-611.
    • (2015) Nature , vol.520 , pp. 609-611
    • Schork, N.J.1
  • 31
    • 70449369661 scopus 로고    scopus 로고
    • Measurement in clinical trials: a neglected issue for statisticians?
    • Senn S, Julious S. Measurement in clinical trials: a neglected issue for statisticians? Statistics in Medicine 2009; 28:3189-3209.
    • (2009) Statistics in Medicine , vol.28 , pp. 3189-3209
    • Senn, S.1    Julious, S.2
  • 32
    • 10644253180 scopus 로고    scopus 로고
    • Disappointing dichotomies
    • Senn SJ. Disappointing dichotomies. Pharmaceutical statistics 2003; 2:239-240.
    • (2003) Pharmaceutical statistics , vol.2 , pp. 239-240
    • Senn, S.J.1
  • 33
    • 77955920415 scopus 로고    scopus 로고
    • Three things every medical writer should know about statistics
    • Senn SJ. Three things every medical writer should know about statistics. The Write Stuff 2009; 18:159-162.
    • (2009) The Write Stuff , vol.18 , pp. 159-162
    • Senn, S.J.1
  • 37
    • 16644391425 scopus 로고    scopus 로고
    • Added values: controversies concerning randomization and additivity in clinical trials
    • Senn SJ. Added values: controversies concerning randomization and additivity in clinical trials. Statistics in Medicine 2004; 23:3729-3753.
    • (2004) Statistics in Medicine , vol.23 , pp. 3729-3753
    • Senn, S.J.1
  • 40
    • 0020334306 scopus 로고
    • Analysis of covariance and standardization as instances of prediction
    • Lane PW, Nelder JA. Analysis of covariance and standardization as instances of prediction. Biometrics 1982; 38:613-621.
    • (1982) Biometrics , vol.38 , pp. 613-621
    • Lane, P.W.1    Nelder, J.A.2
  • 42
    • 0034662061 scopus 로고    scopus 로고
    • Heterogeneity and statistical significance in meta-analysis: an empirical study of 125 meta-analyses
    • Engels EA, Schmid CH, Terrin N, Olkin I, Lau J. Heterogeneity and statistical significance in meta-analysis: an empirical study of 125 meta-analyses. Statistics in Medicine 2000; 19:1707-1728.
    • (2000) Statistics in Medicine , vol.19 , pp. 1707-1728
    • Engels, E.A.1    Schmid, C.H.2    Terrin, N.3    Olkin, I.4    Lau, J.5
  • 43
    • 0028811119 scopus 로고
    • An evidence based approach to individualising treatment
    • Glasziou PP, Irwig LM. An evidence based approach to individualising treatment. British Medical Journal 1995; 311:1356-1359.
    • (1995) British Medical Journal , vol.311 , pp. 1356-1359
    • Glasziou, P.P.1    Irwig, L.M.2
  • 47
    • 0035961549 scopus 로고    scopus 로고
    • Sure outcomes of random events: a model for clinical trials
    • Bouckaert A, Mouchart M. Sure outcomes of random events: a model for clinical trials. Statistics in Medicine 2001; 20:521-543.
    • (2001) Statistics in Medicine , vol.20 , pp. 521-543
    • Bouckaert, A.1    Mouchart, M.2
  • 49
    • 79953210773 scopus 로고    scopus 로고
    • Time to tackle unwarranted variations in practice
    • Wennberg JE. Time to tackle unwarranted variations in practice. BMJ 2011; 342.
    • (2011) BMJ , vol.342
    • Wennberg, J.E.1
  • 50
    • 79957958439 scopus 로고    scopus 로고
    • How Intermountain trimmed health care costs through robust quality improvement efforts
    • James BC, Savitz LA. How Intermountain trimmed health care costs through robust quality improvement efforts. Health Affairs 2011; 30:1185-1191.
    • (2011) Health Affairs , vol.30 , pp. 1185-1191
    • James, B.C.1    Savitz, L.A.2
  • 52
    • 84903511379 scopus 로고    scopus 로고
    • Personalised medicine, disease prevention, and the inverse care law: more harm than benefit?
    • James JE. Personalised medicine, disease prevention, and the inverse care law: more harm than benefit? European Journal of Epidemiology 2014; 29:383-390.
    • (2014) European Journal of Epidemiology , vol.29 , pp. 383-390
    • James, J.E.1
  • 54
    • 79961180449 scopus 로고    scopus 로고
    • Epidemiology, epigenetics and the 'Gloomy Prospect': embracing randomness in population health research and practice
    • Smith GD. Epidemiology, epigenetics and the 'Gloomy Prospect': embracing randomness in population health research and practice. International Journal of Epidemiology 2011; 40:537-562.
    • (2011) International Journal of Epidemiology , vol.40 , pp. 537-562
    • Smith, G.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.