메뉴 건너뛰기




Volumn 59, Issue 4, 2016, Pages 700-708

Metabolic consequences of acute and chronic empagliflozin administration in treatment-naive and metformin pretreated patients with type 2 diabetes

Author keywords

Empagliflozin; Endogenous glucose production; Glycosuria; Metformin; Type 2 diabetes

Indexed keywords

CARBOHYDRATE; EMPAGLIFLOZIN; FAT; GLUCAGON; GLUCOSE; INSULIN; METFORMIN; ANTIDIABETIC AGENT; BENZHYDRYL DERIVATIVE; GLUCOSIDE;

EID: 84959467737     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3845-8     Document Type: Article
Times cited : (24)

References (34)
  • 1
    • 78651349221 scopus 로고    scopus 로고
    • Biology of human sodium glucose transporters
    • COI: 1:CAS:528:DC%2BC3MXns1Cms7g%3D, PID: 21527736
    • Wright EM, Loo DD, Hirayama BA (2011) Biology of human sodium glucose transporters. Physiol Rev 91:733–794
    • (2011) Physiol Rev , vol.91 , pp. 733-794
    • Wright, E.M.1    Loo, D.D.2    Hirayama, B.A.3
  • 2
    • 78651348100 scopus 로고    scopus 로고
    • Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2
    • COI: 1:CAS:528:DC%2BC3MXhsl2qurk%3D, PID: 20980548
    • Hummel CS, Lu C, Loo DD, Hirayama BA, Voss AA, Wright EM (2011) Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol 300:C14–C21
    • (2011) Am J Physiol Cell Physiol , vol.300 , pp. C14-C21
    • Hummel, C.S.1    Lu, C.2    Loo, D.D.3    Hirayama, B.A.4    Voss, A.A.5    Wright, E.M.6
  • 3
    • 78651406659 scopus 로고    scopus 로고
    • SGLT2 mediates glucose reabsorption in the early proximal tubule
    • COI: 1:CAS:528:DC%2BC3MXhsVChsrY%3D, PID: 20616166
    • Vallon V, Platt KA, Cunard R et al (2011) SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol 22:104–112
    • (2011) J Am Soc Nephrol , vol.22 , pp. 104-112
    • Vallon, V.1    Platt, K.A.2    Cunard, R.3
  • 4
    • 84959549507 scopus 로고    scopus 로고
    • Summary of product characteristics, Available from
    • Boehringer Ingelheim International GmbH (2015). Jardiance (empagliflozin). Summary of product characteristics. Available from www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002677/WC500168592.pdf. Accessed 27 Apr 2015
    • (2015) Jardiance (empagliflozin)
  • 5
    • 84959506987 scopus 로고    scopus 로고
    • Summary of product characteristics, Available from
    • AstraZeneca AB (2015). Forxiga (dapagliflozin). Summary of product characteristics. Available from www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002322/WC500136026.pdf. Accessed 27 Apr 2015
    • (2015) Forxiga (dapagliflozin)
    • AstraZeneca, A.B.1
  • 6
    • 84959576591 scopus 로고    scopus 로고
    • Summary of product characteristics, Available from
    • Janssen-Cilag International NV (2015). Invokana (canagliflozin). Summary of product characteristics. Available from www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002649/WC500156456.pdf. Accessed 27 Apr 2015
    • (2015) Invokana (canagliflozin)
  • 7
    • 84900458799 scopus 로고    scopus 로고
    • Ipragliflozin: first global approval
    • COI: 1:CAS:528:DC%2BC2cXmsV2nsbw%3D, PID: 24668021
    • Poole RM, Dungo RT (2014) Ipragliflozin: first global approval. Drugs 74:611–617
    • (2014) Drugs , vol.74 , pp. 611-617
    • Poole, R.M.1    Dungo, R.T.2
  • 8
    • 84902296808 scopus 로고    scopus 로고
    • Tofogliflozin: first global approval
    • COI: 1:CAS:528:DC%2BC2cXoslCgsrY%3D, PID: 24848755
    • Poole RM, Prossler JE (2014) Tofogliflozin: first global approval. Drugs 74:939–944
    • (2014) Drugs , vol.74 , pp. 939-944
    • Poole, R.M.1    Prossler, J.E.2
  • 9
    • 84902240389 scopus 로고    scopus 로고
    • Luseogliflozin: first global approval
    • COI: 1:CAS:528:DC%2BC2cXoslCgsr8%3D, PID: 24848756
    • Markham A, Elkinson S (2014) Luseogliflozin: first global approval. Drugs 74:945–950
    • (2014) Drugs , vol.74 , pp. 945-950
    • Markham, A.1    Elkinson, S.2
  • 10
    • 84864146681 scopus 로고    scopus 로고
    • LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BC38XhtVOmtrfP, PID: 22739142
    • Zambrowicz B, Freiman J, Brown PM et al (2012) LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther 92:158–169
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 158-169
    • Zambrowicz, B.1    Freiman, J.2    Brown, P.M.3
  • 11
    • 84928381216 scopus 로고    scopus 로고
    • Dose-ranging efficacy and safety study of ertugliflozin, a sodium-glucose co-transporter 2 inhibitor, in patients with type 2 diabetes on a background of metformin
    • COI: 1:CAS:528:DC%2BC2MXntFGgsLo%3D, PID: 25754396
    • Amin NB, Wang X, Jain SM, Lee DS, Nucci G, Rusnak JM (2015) Dose-ranging efficacy and safety study of ertugliflozin, a sodium-glucose co-transporter 2 inhibitor, in patients with type 2 diabetes on a background of metformin. Diabetes Obes Metab 17:591–598
    • (2015) Diabetes Obes Metab , vol.17 , pp. 591-598
    • Amin, N.B.1    Wang, X.2    Jain, S.M.3    Lee, D.S.4    Nucci, G.5    Rusnak, J.M.6
  • 12
    • 84919489425 scopus 로고    scopus 로고
    • Randomized efficacy and safety trial of once-daily remogliflozin etabonate for the treatment of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2cXitVylurvM, PID: 25238025
    • Sykes AP, Kemp GL, Dobbins R et al (2015) Randomized efficacy and safety trial of once-daily remogliflozin etabonate for the treatment of type 2 diabetes. Diabetes Obes Metab 17:98–101
    • (2015) Diabetes Obes Metab , vol.17 , pp. 98-101
    • Sykes, A.P.1    Kemp, G.L.2    Dobbins, R.3
  • 13
    • 84864283226 scopus 로고    scopus 로고
    • SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects
    • COI: 1:CAS:528:DC%2BC38XhtVOmtLjM, PID: 22310849
    • Ferrannini E, Solini A (2012) SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects. Nat Rev Endocrinol 8:495–502
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 495-502
    • Ferrannini, E.1    Solini, A.2
  • 14
    • 84912533839 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin for type 2 diabetes: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC2cXhsFahtbvE, PID: 24766495
    • Liakos A, Karagiannis T, Athanasiadou E et al (2014) Efficacy and safety of empagliflozin for type 2 diabetes: a systematic review and meta-analysis. Diabetes Obes Metab 16:984–993
    • (2014) Diabetes Obes Metab , vol.16 , pp. 984-993
    • Liakos, A.1    Karagiannis, T.2    Athanasiadou, E.3
  • 15
    • 84930580913 scopus 로고    scopus 로고
    • Update on long-term efficacy and safety of dapagliflozin in patients with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2MXotVamt78%3D, PID: 25941564
    • Liakos A, Karagiannis T, Bekiari E, Boura P, Tsapas A (2015) Update on long-term efficacy and safety of dapagliflozin in patients with type 2 diabetes mellitus. Ther Adv Endocrinol Metab 6:61–67
    • (2015) Ther Adv Endocrinol Metab , vol.6 , pp. 61-67
    • Liakos, A.1    Karagiannis, T.2    Bekiari, E.3    Boura, P.4    Tsapas, A.5
  • 16
    • 84901830673 scopus 로고    scopus 로고
    • Canagliflozin: a review of its use in patients with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXotFOqtLs%3D, PID: 24831734
    • Plosker G (2014) Canagliflozin: a review of its use in patients with type 2 diabetes mellitus. Drugs 74:807–824
    • (2014) Drugs , vol.74 , pp. 807-824
    • Plosker, G.1
  • 17
    • 84887191925 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia
    • COI: 1:CAS:528:DC%2BC3sXhslCrs7%2FI, PID: 23906374
    • Rosenstock J, Seman LJ, Jelaska A et al (2013) Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia. Diabetes Obes Metab 15:1154–1160
    • (2013) Diabetes Obes Metab , vol.15 , pp. 1154-1160
    • Rosenstock, J.1    Seman, L.J.2    Jelaska, A.3
  • 18
    • 84891851923 scopus 로고    scopus 로고
    • Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3sXhvFaksLrE, PID: 24186878
    • Ferrannini E, Berk A, Hantel S et al (2013) Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes. Diabetes Care 36:4015–4021
    • (2013) Diabetes Care , vol.36 , pp. 4015-4021
    • Ferrannini, E.1    Berk, A.2    Hantel, S.3
  • 19
    • 84901455931 scopus 로고    scopus 로고
    • Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial
    • PID: 24722494
    • Häring HU, Merker L, Seewaldt-Becker E et al (2014) Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Care 37:1650–1659
    • (2014) Diabetes Care , vol.37 , pp. 1650-1659
    • Häring, H.U.1    Merker, L.2    Seewaldt-Becker, E.3
  • 20
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose co-transporter-2 inhibition in type 2 diabetic patients
    • COI: 1:CAS:528:DC%2BC2cXis1ers7c%3D, PID: 24463454
    • Ferrannini E, Muscelli E, Frascerra S et al (2014) Metabolic response to sodium-glucose co-transporter-2 inhibition in type 2 diabetic patients. J Clin Invest 124:499–508
    • (2014) J Clin Invest , vol.124 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3
  • 21
    • 84893827104 scopus 로고    scopus 로고
    • Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
    • COI: 1:CAS:528:DC%2BC2cXis1ersL0%3D, PID: 24463448
    • Merovci A, Solis-Herrera C, Daniele G et al (2014) Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest 124:509–514
    • (2014) J Clin Invest , vol.124 , pp. 509-514
    • Merovci, A.1    Solis-Herrera, C.2    Daniele, G.3
  • 22
    • 82255185902 scopus 로고    scopus 로고
    • Control of blood glucose in the absence of hepatic glucose production during prolonged fasting in mice: induction of renal and intestinal gluconeogenesis by glucagon
    • COI: 1:CAS:528:DC%2BC38XpvFOitg%3D%3D, PID: 22013018
    • Mutel E, Gautier-Stein A, Abdul-Wahed A et al (2011) Control of blood glucose in the absence of hepatic glucose production during prolonged fasting in mice: induction of renal and intestinal gluconeogenesis by glucagon. Diabetes 60:3121–3131
    • (2011) Diabetes , vol.60 , pp. 3121-3131
    • Mutel, E.1    Gautier-Stein, A.2    Abdul-Wahed, A.3
  • 23
    • 84925489733 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • PID: 25583541
    • Inzucchi SE, Bergenstal RM, Buse JB et al (2015) Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 58:429–442
    • (2015) Diabetologia , vol.58 , pp. 429-442
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 24
    • 84908080513 scopus 로고    scopus 로고
    • The target of metformin in type 2 diabetes
    • PID: 25317875
    • Ferrannini E (2014) The target of metformin in type 2 diabetes. N Engl J Med 371:1547–1548
    • (2014) N Engl J Med , vol.371 , pp. 1547-1548
    • Ferrannini, E.1
  • 25
    • 33846570905 scopus 로고    scopus 로고
    • Effect of pioglitazone on the metabolic and hormonal response to a mixed meal in type II diabetes
    • COI: 1:CAS:528:DC%2BD2sXisFyrtLc%3D, PID: 17259945
    • Gastaldelli A, Casolaro A, Pettiti M et al (2007) Effect of pioglitazone on the metabolic and hormonal response to a mixed meal in type II diabetes. Clin Pharmacol Ther 81:205–212
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 205-212
    • Gastaldelli, A.1    Casolaro, A.2    Pettiti, M.3
  • 26
    • 0018864615 scopus 로고
    • Total body water volumes for adult males and females estimated from simple anthropometric measurements
    • COI: 1:CAS:528:DyaL3cXht1GltL0%3D, PID: 6986753
    • Watson PE, Watson ID, Batt RD (1980) Total body water volumes for adult males and females estimated from simple anthropometric measurements. Am J Clin Nutr 33:27–39
    • (1980) Am J Clin Nutr , vol.33 , pp. 27-39
    • Watson, P.E.1    Watson, I.D.2    Batt, R.D.3
  • 27
    • 0037866804 scopus 로고    scopus 로고
    • A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models
    • Mari A, Stojanovska L, Proietto J, Thorburn AW (2003) A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models. Comput Methods Prog Biomed 71:269–281
    • (2003) Comput Methods Prog Biomed , vol.71 , pp. 269-281
    • Mari, A.1    Stojanovska, L.2    Proietto, J.3    Thorburn, A.W.4
  • 28
    • 0023930822 scopus 로고
    • The theoretical bases of indirect calorimetry: a review
    • COI: 1:CAS:528:DyaL1cXptFWisA%3D%3D, PID: 3278194
    • Ferrannini E (1988) The theoretical bases of indirect calorimetry: a review. Metabolism 37:287–301
    • (1988) Metabolism , vol.37 , pp. 287-301
    • Ferrannini, E.1
  • 29
    • 0036889282 scopus 로고    scopus 로고
    • Meal and oral glucose tests for assessment of β-cell action: modelling analysis in normal subjects
    • COI: 1:CAS:528:DC%2BD38XpslGjtbc%3D, PID: 12388151
    • Mari A, Schmitz O, Gastaldelli A, Oestergaard T, Nyholm B, Ferrannini E (2002) Meal and oral glucose tests for assessment of β-cell action: modelling analysis in normal subjects. Am J Physiol Endocrinol Metab 283:E1159–E1166
    • (2002) Am J Physiol Endocrinol Metab , vol.283 , pp. E1159-E1166
    • Mari, A.1    Schmitz, O.2    Gastaldelli, A.3    Oestergaard, T.4    Nyholm, B.5    Ferrannini, E.6
  • 30
    • 0026504160 scopus 로고
    • Estimation of insulin secretion rates from C-peptide levels: comparison of individual and standard kinetic parameters for C-peptide clearance
    • PID: 1551497
    • Van Cauter E, Mestrez F, Sturis J, Polonsky KS (1992) Estimation of insulin secretion rates from C-peptide levels: comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes 41:368–377
    • (1992) Diabetes , vol.41 , pp. 368-377
    • Van Cauter, E.1    Mestrez, F.2    Sturis, J.3    Polonsky, K.S.4
  • 31
    • 84907970634 scopus 로고    scopus 로고
    • Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity?
    • COI: 1:CAS:528:DC%2BC2cXhtlOlt77N, PID: 25172519
    • Wu T, Thazhath SS, Bound MJ, Jones KL, Horowitz M, Rayner CK (2014) Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity? Diabetes Res Clin Pract 106:e3–e6
    • (2014) Diabetes Res Clin Pract , vol.106 , pp. e3-e6
    • Wu, T.1    Thazhath, S.S.2    Bound, M.J.3    Jones, K.L.4    Horowitz, M.5    Rayner, C.K.6
  • 32
    • 78649908592 scopus 로고    scopus 로고
    • Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC3cXhsFamt7jP, PID: 20152998
    • Cuthbertson J, Patterson S, O’Harte FP, Bell PM (2011) Addition of metformin to exogenous glucagon-like peptide-1 results in increased serum glucagon-like peptide-1 concentrations and greater glucose lowering in type 2 diabetes mellitus. Metabolism 60:52–56
    • (2011) Metabolism , vol.60 , pp. 52-56
    • Cuthbertson, J.1    Patterson, S.2    O’Harte, F.P.3    Bell, P.M.4
  • 33
    • 84951906012 scopus 로고    scopus 로고
    • Energy balance following sodium-glucose co-transporter-2 (SGLT2) inhibition
    • PID: 26180105
    • Ferrannini G, Hach T, Crowe S, Sanghvi A, Hall KD, Ferrannini E (2015) Energy balance following sodium-glucose co-transporter-2 (SGLT2) inhibition. Diabetes Care 38:1730–1735
    • (2015) Diabetes Care , vol.38 , pp. 1730-1735
    • Ferrannini, G.1    Hach, T.2    Crowe, S.3    Sanghvi, A.4    Hall, K.D.5    Ferrannini, E.6
  • 34
    • 84962339296 scopus 로고    scopus 로고
    • Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition
    • PID: 26078479
    • Peters AL, Buschur EO, Buse JB et al (2015) Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care 38:1687–1693
    • (2015) Diabetes Care , vol.38 , pp. 1687-1693
    • Peters, A.L.1    Buschur, E.O.2    Buse, J.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.