-
1
-
-
84923357083
-
Homeostasis, inflammation, and disease susceptibility
-
Kotas M.E., Medzhitov R. Homeostasis, inflammation, and disease susceptibility. Cell 2015, 160:816-827.
-
(2015)
Cell
, vol.160
, pp. 816-827
-
-
Kotas, M.E.1
Medzhitov, R.2
-
2
-
-
77950346282
-
Immunity, inflammation, and cancer
-
Grivennikov S.I., Greten F.R., Karin M. Immunity, inflammation, and cancer. Cell 2010, 140:883-899.
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
4
-
-
59649117667
-
Molecular biology of inflammation and sepsis: a primer
-
Cinel I., Opal S.M. Molecular biology of inflammation and sepsis: a primer. Crit. Care Med. 2009, 37:291-304.
-
(2009)
Crit. Care Med.
, vol.37
, pp. 291-304
-
-
Cinel, I.1
Opal, S.M.2
-
5
-
-
0037180771
-
Inflammation in atherosclerosis
-
Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
-
(2002)
Nature
, vol.420
, pp. 868-874
-
-
Libby, P.1
-
6
-
-
17644412023
-
Inflammation, atherosclerosis, and coronary artery disease
-
Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 2005, 352:1685-1695.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 1685-1695
-
-
Hansson, G.K.1
-
7
-
-
34250823515
-
Gene-specific control of inflammation by TLR-induced chromatin modifications
-
Foster S.L., Hargreaves D.C., Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007, 447:972-978.
-
(2007)
Nature
, vol.447
, pp. 972-978
-
-
Foster, S.L.1
Hargreaves, D.C.2
Medzhitov, R.3
-
8
-
-
84880044900
-
MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways
-
Cheng H.S., Sivachandran N., Lau A., Boudreau E., Zhao J.L., Baltimore D., Delgado-Olguin P., Cybulsky M.I., Fish J.E. MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways. EMBO Mol. Med. 2013, 5:949-966.
-
(2013)
EMBO Mol. Med.
, vol.5
, pp. 949-966
-
-
Cheng, H.S.1
Sivachandran, N.2
Lau, A.3
Boudreau, E.4
Zhao, J.L.5
Baltimore, D.6
Delgado-Olguin, P.7
Cybulsky, M.I.8
Fish, J.E.9
-
9
-
-
84908602740
-
NF-kappaB directs dynamic super enhancer formation in inflammation and atherogenesis
-
Brown J.D., Lin C.Y., Duan Q., Griffin G., Federation A.J., Paranal R.M., Bair S., Newton G., Lichtman A.H., Kung A.L., Yang T., Wang H., Luscinskas F.W., Croce K.J., Bradner J.E., Plutzky J. NF-kappaB directs dynamic super enhancer formation in inflammation and atherogenesis. Mol. Cell 2014, 56:219-231.
-
(2014)
Mol. Cell
, vol.56
, pp. 219-231
-
-
Brown, J.D.1
Lin, C.Y.2
Duan, Q.3
Griffin, G.4
Federation, A.J.5
Paranal, R.M.6
Bair, S.7
Newton, G.8
Lichtman, A.H.9
Kung, A.L.10
Yang, T.11
Wang, H.12
Luscinskas, F.W.13
Croce, K.J.14
Bradner, J.E.15
Plutzky, J.16
-
10
-
-
78650806593
-
Suppression of inflammation by a synthetic histone mimic
-
Nicodeme E., Jeffrey K.L., Schaefer U., Beinke S., Dewell S., Chung C.W., Chandwani R., Marazzi I., Wilson P., Coste H., White J., Kirilovsky J., Rice C.M., Lora J.M., Prinjha R.K., Lee K., Tarakhovsky A. Suppression of inflammation by a synthetic histone mimic. Nature 2010, 468:1119-1123.
-
(2010)
Nature
, vol.468
, pp. 1119-1123
-
-
Nicodeme, E.1
Jeffrey, K.L.2
Schaefer, U.3
Beinke, S.4
Dewell, S.5
Chung, C.W.6
Chandwani, R.7
Marazzi, I.8
Wilson, P.9
Coste, H.10
White, J.11
Kirilovsky, J.12
Rice, C.M.13
Lora, J.M.14
Prinjha, R.K.15
Lee, K.16
Tarakhovsky, A.17
-
11
-
-
84876222028
-
Selective inhibition of tumor oncogenes by disruption of super-enhancers
-
Loven J., Hoke H.A., Lin C.Y., Lau A., Orlando D.A., Vakoc C.R., Bradner J.E., Lee T.I., Young R.A. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell 2013, 153:320-334.
-
(2013)
Cell
, vol.153
, pp. 320-334
-
-
Loven, J.1
Hoke, H.A.2
Lin, C.Y.3
Lau, A.4
Orlando, D.A.5
Vakoc, C.R.6
Bradner, J.E.7
Lee, T.I.8
Young, R.A.9
-
12
-
-
84888015137
-
Super-enhancers in the control of cell identity and disease
-
Hnisz D., Abraham B.J., Lee T.I., Lau A., Saint-Andre V., Sigova A.A., Hoke H.A., Young R.A. Super-enhancers in the control of cell identity and disease. Cell 2013, 155:934-947.
-
(2013)
Cell
, vol.155
, pp. 934-947
-
-
Hnisz, D.1
Abraham, B.J.2
Lee, T.I.3
Lau, A.4
Saint-Andre, V.5
Sigova, A.A.6
Hoke, H.A.7
Young, R.A.8
-
13
-
-
8144225486
-
MicroRNA genes are transcribed by RNA polymerase II
-
Lee Y., Kim M., Han J., Yeom K.H., Lee S., Baek S.H., Kim V.N. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004, 23:4051-4060.
-
(2004)
EMBO J.
, vol.23
, pp. 4051-4060
-
-
Lee, Y.1
Kim, M.2
Han, J.3
Yeom, K.H.4
Lee, S.5
Baek, S.H.6
Kim, V.N.7
-
14
-
-
56549129538
-
Chromatin structure analyses identify miRNA promoters
-
Ozsolak F., Poling L.L., Wang Z., Liu H., Liu X.S., Roeder R.G., Zhang X., Song J.S., Fisher D.E. Chromatin structure analyses identify miRNA promoters. Genes Dev. 2008, 22:3172-3183.
-
(2008)
Genes Dev.
, vol.22
, pp. 3172-3183
-
-
Ozsolak, F.1
Poling, L.L.2
Wang, Z.3
Liu, H.4
Liu, X.S.5
Roeder, R.G.6
Zhang, X.7
Song, J.S.8
Fisher, D.E.9
-
15
-
-
33747608638
-
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
-
Taganov K.D., Boldin M.P., Chang K.J., Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:12481-12486.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 12481-12486
-
-
Taganov, K.D.1
Boldin, M.P.2
Chang, K.J.3
Baltimore, D.4
-
16
-
-
38049030287
-
Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock
-
Tili E., Michaille J.J., Cimino A., Costinean S., Dumitru C.D., Adair B., Fabbri M., Alder H., Liu C.G., Calin G.A., Croce C.M. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J. Immunol. 2007, 179:5082-5089.
-
(2007)
J. Immunol.
, vol.179
, pp. 5082-5089
-
-
Tili, E.1
Michaille, J.J.2
Cimino, A.3
Costinean, S.4
Dumitru, C.D.5
Adair, B.6
Fabbri, M.7
Alder, H.8
Liu, C.G.9
Calin, G.A.10
Croce, C.M.11
-
17
-
-
84858722006
-
MicroRNAs, new effectors and regulators of NF-kappaB
-
Boldin M.P., Baltimore D. MicroRNAs, new effectors and regulators of NF-kappaB. Immunol. Rev. 2012, 246:205-220.
-
(2012)
Immunol. Rev.
, vol.246
, pp. 205-220
-
-
Boldin, M.P.1
Baltimore, D.2
-
18
-
-
77951964981
-
Posttranscriptional regulation of microRNA biogenesis in animals
-
Siomi H., Siomi M.C. Posttranscriptional regulation of microRNA biogenesis in animals. Mol. Cell 2010, 38:323-332.
-
(2010)
Mol. Cell
, vol.38
, pp. 323-332
-
-
Siomi, H.1
Siomi, M.C.2
-
19
-
-
84904985459
-
Regulation of microRNA biogenesis
-
Ha M., Kim V.N. Regulation of microRNA biogenesis. Nat. Rev. Mol. Cell Biol. 2014, 15:509-524.
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 509-524
-
-
Ha, M.1
Kim, V.N.2
-
20
-
-
55049132350
-
Regulation of mammalian microRNA processing and function by cellular signaling and subcellular localization
-
Smalheiser N.R. Regulation of mammalian microRNA processing and function by cellular signaling and subcellular localization. Biochim. Biophys. Acta 2008, 1779:678-681.
-
(2008)
Biochim. Biophys. Acta
, vol.1779
, pp. 678-681
-
-
Smalheiser, N.R.1
-
21
-
-
84876216563
-
Master transcription factors and mediator establish super-enhancers at key cell identity genes
-
Whyte W.A., Orlando D.A., Hnisz D., Abraham B.J., Lin C.Y., Kagey M.H., Rahl P.B., Lee T.I., Young R.A. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 2013, 153:307-319.
-
(2013)
Cell
, vol.153
, pp. 307-319
-
-
Whyte, W.A.1
Orlando, D.A.2
Hnisz, D.3
Abraham, B.J.4
Lin, C.Y.5
Kagey, M.H.6
Rahl, P.B.7
Lee, T.I.8
Young, R.A.9
-
22
-
-
78650758676
-
Histone H3K27ac separates active from poised enhancers and predicts developmental state
-
Creyghton M.P., Cheng A.W., Welstead G.G., Kooistra T., Carey B.W., Steine E.J., Hanna J., Lodato M.A., Frampton G.M., Sharp P.A., Boyer L.A., Young R.A., Jaenisch R. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:21931-21936.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 21931-21936
-
-
Creyghton, M.P.1
Cheng, A.W.2
Welstead, G.G.3
Kooistra, T.4
Carey, B.W.5
Steine, E.J.6
Hanna, J.7
Lodato, M.A.8
Frampton, G.M.9
Sharp, P.A.10
Boyer, L.A.11
Young, R.A.12
Jaenisch, R.13
-
23
-
-
84925283769
-
What are super-enhancers?
-
Pott S., Lieb J.D. What are super-enhancers?. Nat. Genet. 2015, 47:8-12.
-
(2015)
Nat. Genet.
, vol.47
, pp. 8-12
-
-
Pott, S.1
Lieb, J.D.2
-
24
-
-
79953057954
-
Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration
-
Zhu N., Zhang D., Chen S., Liu X., Lin L., Huang X., Guo Z., Liu J., Wang Y., Yuan W., Qin Y. Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration. Atherosclerosis 2011, 215:286-293.
-
(2011)
Atherosclerosis
, vol.215
, pp. 286-293
-
-
Zhu, N.1
Zhang, D.2
Chen, S.3
Liu, X.4
Lin, L.5
Huang, X.6
Guo, Z.7
Liu, J.8
Wang, Y.9
Yuan, W.10
Qin, Y.11
-
25
-
-
84955279894
-
ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas
-
Yang H., Schramek D., Adam R.C., Keyes B.E., Wang P., Zheng D., Fuchs E. ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. ELIFE 2015, 4.
-
(2015)
ELIFE
, vol.4
-
-
Yang, H.1
Schramek, D.2
Adam, R.C.3
Keyes, B.E.4
Wang, P.5
Zheng, D.6
Fuchs, E.7
-
26
-
-
23744467035
-
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4
-
Yang Z., Yik J.H., Chen R., He N., Jang M.K., Ozato K., Zhou Q. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Mol. Cell 2005, 19:535-545.
-
(2005)
Mol. Cell
, vol.19
, pp. 535-545
-
-
Yang, Z.1
Yik, J.H.2
Chen, R.3
He, N.4
Jang, M.K.5
Ozato, K.6
Zhou, Q.7
-
27
-
-
23744514308
-
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription
-
Jang M.K., Mochizuki K., Zhou M., Jeong H.S., Brady J.N., Ozato K. The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. Mol. Cell 2005, 19:523-534.
-
(2005)
Mol. Cell
, vol.19
, pp. 523-534
-
-
Jang, M.K.1
Mochizuki, K.2
Zhou, M.3
Jeong, H.S.4
Brady, J.N.5
Ozato, K.6
-
28
-
-
67649648237
-
Control of inducible genes expression by signal-dependent transcriptional elongation
-
Hargreaves D.C., Horng T., Medzhitov R. Control of inducible genes expression by signal-dependent transcriptional elongation. Cell 2009, 138:129-145.
-
(2009)
Cell
, vol.138
, pp. 129-145
-
-
Hargreaves, D.C.1
Horng, T.2
Medzhitov, R.3
-
29
-
-
68449097267
-
MiR-145 and miR-143 regulate smooth muscle cell fate and plasticity
-
Cordes K.R., Sheehy N.T., White M.P., Berry E.C., Morton S.U., Muth A.N., Lee T.H., Miano J.M., Ivey K.N., Srivastava D. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 2009, 460:705-710.
-
(2009)
Nature
, vol.460
, pp. 705-710
-
-
Cordes, K.R.1
Sheehy, N.T.2
White, M.P.3
Berry, E.C.4
Morton, S.U.5
Muth, A.N.6
Lee, T.H.7
Miano, J.M.8
Ivey, K.N.9
Srivastava, D.10
-
30
-
-
79959691239
-
MiR-143 and miR-145: molecular keys to switch the phenotype of vascular smooth muscle cells
-
Rangrez A.Y., Massy Z.A., Metzinger-Le M.V., Metzinger L. miR-143 and miR-145: molecular keys to switch the phenotype of vascular smooth muscle cells. Circ. Cardiovasc. Genet. 2011, 4:197-205.
-
(2011)
Circ. Cardiovasc. Genet.
, vol.4
, pp. 197-205
-
-
Rangrez, A.Y.1
Massy, Z.A.2
Metzinger-Le, M.V.3
Metzinger, L.4
-
31
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
Filippakopoulos P., Qi J., Picaud S., Shen Y., Smith W.B., Fedorov O., Morse E.M., Keates T., Hickman T.T., Felletar I., Philpott M., Munro S., McKeown M.R., Wang Y., Christie A.L., West N., Cameron M.J., Schwartz B., Heightman T.D., La Thangue N., French C.A., Wiest O., Kung A.L., Knapp S., Bradner J.E. Selective inhibition of BET bromodomains. Nature 2010, 468:1067-1073.
-
(2010)
Nature
, vol.468
, pp. 1067-1073
-
-
Filippakopoulos, P.1
Qi, J.2
Picaud, S.3
Shen, Y.4
Smith, W.B.5
Fedorov, O.6
Morse, E.M.7
Keates, T.8
Hickman, T.T.9
Felletar, I.10
Philpott, M.11
Munro, S.12
McKeown, M.R.13
Wang, Y.14
Christie, A.L.15
West, N.16
Cameron, M.J.17
Schwartz, B.18
Heightman, T.D.19
La Thangue, N.20
French, C.A.21
Wiest, O.22
Kung, A.L.23
Knapp, S.24
Bradner, J.E.25
more..
-
32
-
-
77952713824
-
RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo
-
Bailey D., Jahagirdar R., Gordon A., Hafiane A., Campbell S., Chatur S., Wagner G.S., Hansen H.C., Chiacchia F.S., Johansson J., Krimbou L., Wong N.C., Genest J. RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo. J. Am. Coll. Cardiol. 2010, 55:2580-2589.
-
(2010)
J. Am. Coll. Cardiol.
, vol.55
, pp. 2580-2589
-
-
Bailey, D.1
Jahagirdar, R.2
Gordon, A.3
Hafiane, A.4
Campbell, S.5
Chatur, S.6
Wagner, G.S.7
Hansen, H.C.8
Chiacchia, F.S.9
Johansson, J.10
Krimbou, L.11
Wong, N.C.12
Genest, J.13
-
33
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
Delmore J.E., Issa G.C., Lemieux M.E., Rahl P.B., Shi J., Jacobs H.M., Kastritis E., Gilpatrick T., Paranal R.M., Qi J., Chesi M., Schinzel A.C., McKeown M.R., Heffernan T.P., Vakoc C.R., Bergsagel P.L., Ghobrial I.M., Richardson P.G., Young R.A., Hahn W.C., Anderson K.C., Kung A.L., Bradner J.E., Mitsiades C.S. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 2011, 146:904-917.
-
(2011)
Cell
, vol.146
, pp. 904-917
-
-
Delmore, J.E.1
Issa, G.C.2
Lemieux, M.E.3
Rahl, P.B.4
Shi, J.5
Jacobs, H.M.6
Kastritis, E.7
Gilpatrick, T.8
Paranal, R.M.9
Qi, J.10
Chesi, M.11
Schinzel, A.C.12
McKeown, M.R.13
Heffernan, T.P.14
Vakoc, C.R.15
Bergsagel, P.L.16
Ghobrial, I.M.17
Richardson, P.G.18
Young, R.A.19
Hahn, W.C.20
Anderson, K.C.21
Kung, A.L.22
Bradner, J.E.23
Mitsiades, C.S.24
more..
|