Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

Journal of Medicinal Chemistry

Volumn 59, Issue 4, 2016, Pages 1634-1641

  Raux, Brigitt ^a   Voitovich, Yuliia ^a,b   Derviaux, Carine ^a   Lugari, Adrien ^a,h   Rebuffet, Etienne ^a   Milhas, Sabine ^a,c   Priet, Stéphane ^c   Roux, Thomas ^d   Trinquet, Eric ^d   Guillemot, Jean Claude ^c   Knapp, Stefan ^e,f,g   Brunel, Jean Michel ^a   Fedorov, Alexey Yu ^b   Collette, Yves ^a   Roche, Philippe ^a   Betzi, Stéphane ^a   Combes, Sébastien ^a   Morelli, Xavier ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b LOBACHEVSKY STATE UNIVERSITY OF NIZHNY NOVGOROD   (Russian Federation)

^c AIX MARSEILLE UNIVERSITY   (France)

^d Cisbio Bioassays   (France)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g GOETHE UNIVERSITY   (Germany)

^h BIOASTER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BROMODOMAIN INHIBITOR; XANTHINE DERIVATIVE; BRD4 PROTEIN, HUMAN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; PROTEIN DOMAIN; ACETYLATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; METABOLISM; MOLECULAR MODEL; PROTEIN TERTIARY STRUCTURE;

ACETYLATION; DRUG DISCOVERY; HUMANS; MODELS, MOLECULAR; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS; XANTHINES;

EID: 84959387458     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01708     Document Type: Article

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