Structure enabled design of BaZ2-ICR, a chemical probe targeting the bromodomains of BaZ2a and BaZ2B

Journal of Medicinal Chemistry

Volumn 58, Issue 5, 2015, Pages 2553-2559

  Drouin, Ludovic ^a   McGrath, Sally ^a   Vidler, Lewis R ^a   Chaikuad, Apirat ^b   Monteiro, Octovia ^b,c   Tallant, Cynthia ^b,c   Philpott, Martin ^b,c   Rogers, Catherine ^b,c   Fedorov, Oleg ^b,c   Liu, Manjuan ^a   Akhtar, Wasim ^a   Hayes, Angela ^a   Raynaud, Florence ^a   Müller, Susanne ^b,c   Knapp, Stefan ^b,c   Hoelder, Swen ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN2 ICR; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN2A; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN2B; BROMODOMAIN INHIBITOR; UNCLASSIFIED DRUG; BAZ2A PROTEIN, HUMAN; MOLECULAR PROBE; NONHISTONE PROTEIN; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; ISOTHERMAL TITRATION CALORIMETRY; MOUSE; NONHUMAN; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; VOLUME OF DISTRIBUTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; MICROSOME; MOLECULAR PROBE; PHARMACOLOGY;

ANIMALS; CHROMOSOMAL PROTEINS, NON-HISTONE; DRUG DESIGN; MICE; MICROSOMES; MODELS, MOLECULAR; MOLECULAR PROBES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84924674529     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501963e     Document Type: Article

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