Ethyl pyruvate protects against sepsis by regulating energy metabolism

Therapeutics and Clinical Risk Management

Volumn 12, Issue , 2016, Pages 287-294

  Kang, Hongjun ^a   Mao, Zhi ^a   Zhao, Yan ^a   Yin, Ting ^b   Song, Qing ^a   Pan, Liang ^a   Hu, Xin ^a   Hu, Jie ^a   Zhou, Feihu ^a  

^a Chinese General Hospital   (China)

^b The Centre Hospital of BaoTou   (China)

Author keywords

Energy metabolism; Ethyl pyruvate; Inflammation; Reactive oxygen species; Sepsis

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ETHYL PYRUVATE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTIC ACID; MALONALDEHYDE; PYRUVIC ACID; PYRUVIC ACID DERIVATIVE; RINGER LACTATE SOLUTION; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; CONTROLLED STUDY; DRUG EFFECT; ENERGY METABOLISM; HISTOPATHOLOGY; INTESTINE; LAPAROTOMY; LIVER; LIVER HOMOGENATE; MALE; METABOLIC ACIDOSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTECTION; PROTEIN BLOOD LEVEL; SURVIVAL RATE;

EID: 84959340794     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S97989     Document Type: Article

References (29)

1. Shapiro N, Howell MD, Bates DW, et al. The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection. Ann Emerg Med. 2006; 48(5):583-590.
2. Kleinpell RM, Graves BT, Ackerman MH. Incidence, pathogenesis, and management of sepsis: an overview. AACN Adv Crit Care. 2006;17(4):385-393.
3. Olivencia-Yurvati AH, Blair JL, Baig M, Mallet RT. Pyruvate-enhanced cardioprotection during surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2003;17(6):715-720.
4. Sims CA, Wattanasirichaigoon S, Menconi MJ, Ajami AM, Fink MP. Ringer’s ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosa injury in rats. Crit Care Med. 2001;29(8): 1513-1518.
5. Tawadrous ZS, Delude RL, Fink MP. Resuscitation from hemorrhagic shock with Ringer’s ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats. Shock. 2002;17(6): 473-477.
6. Guo J, Zhang J, Luo X, et al. Effects of ethyl pyruvate on cardiac function recovery and apoptosis reduction after global cold ischemia and reperfusion. Exp Ther Med. 2014;7(5):1197-1202.
7. Hu X, Cui B, Zhou X, et al. Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Mol Biol Rep. 2012;39(1):227-231.
8. Pravda J. Metabolic theory of septic shock. World J Crit Care Med. 2014;3(2):45-54.
9. Wang X, Qin W, Qiu X, et al. A novel role of exogenous carbon monoxide on protecting cardiac function and improving survival against sepsis via mitochondrial energetic metabolism pathway. Int J Biol Sci. 2014;10(7):777-788.
10. Crouser ED. Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion. 2004;4(56):729-741.
11. Rittirsch D, Huber-Laang MS, Flierl MA, Ward PA. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc. 2009; 4(1):31-36.
12. Uchiyama T, Delude RL, Fink MP. Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion. Intensive Care Med. 2003;29(11):2050-2058.
13. Chiu CJ, Mc Ardle AH, Brown R, Scott HJ, Gurd FN. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg. 1970;101(4):478-483.
14. Kammermeier H. Meaning of energetic parameters. Basic Res Cardiol. 1993;88(5):380-384.
15. Manfredi G, Yang L, Gajewski CD, Mattiazzi M. Measurements of ATP in mammalian cells. Methods. 2002;26(4):317-326.
16. Zur Nedden S, Eason R, Doney AS, Frenguelli BG. An ion-pair reversed-phase HPLC method for determination of fresh tissue adenine nucleotides avoiding freeze-thaw degradation of ATP. Anal Biochem. 2009;388(1):108-114.
17. Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med. 2013;369(9):840-851.
18. Haupt W, Fritzsche H, Hohenberger W, Zirngibl H. Selective cytokine release induced by serum and separated plasma from septic patients. Eur J Surg. 1996;162(10):769-776.
19. Ulloa L, Ochani M, Yang H, et al. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A. 2002;99(19):12351-12356.
20. Fink MP. Ethyl pyruvate: a novel anti-inflammatory agent. J Intern Med. 2007;261(4):349-362.
21. Venkataraman R, Kellum JA, Song M, Fink MP. Resuscitation with Ringer’s ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentration in a rat model of lipopolysaccharide-induced shock. Shock. 2002;18(6):507-512.
22. Ozawa K, Fujimoto T, Nakatani T, et al. Changes in hepatic energy charge, blood ketone ratio, and indocyanine green clearance in relation to DNA synthesis after hepatectomy. Life Sci. 1982;31(7): 647-653.
23. Minemura M, Tajiri K, Shimizu Y. Liver involvement in systemic infection. World J Hepatol. 2014;6(9):632-642.
24. Waelgaard L, Dahl BM, Kvarstein G, Tonnessen T. Tissue gas tension and tissue metabolites for detection of organ hypoperfusion and ischemia. Acta Anaesthesiol Scand. 2012;56(2):200-209.
25. Burša F, Pleva L, Máca J, Sklienka P, Ševčík P. Tissue ischemia microdialysis assessments following severe traumatic haemorrhagic shock: lactate/pyruvate ratio as a new resuscitation end point. BMC Anesthesiol. 2014;14:118-126.
26. Crawford RS, Albadawi H, Atkins MD, et al. Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb ischemia and reperfusion. J Trauma. 2011;70(1): 103-110.
27. Sheth H, Hafez T, Glantzounis GK, et al. Glycine maintains mitochondrial activity and bile composition following warm liver ischemia-reperfusion injury. J Gastroenterol Hepatol. 2011;26(1):194-200.
28. Shen LC, Fall L, Walton GM, Atkinson DE. Interaction between energy charge and metabolite modulation in the regulation of enzymes of amphibolic sequences. Phosphofructokinase and pyruvate dehydrogenase. Biochemistry. 1968;7(11):4041-4045.
29. Woo YJ, Taylor MD, Cohen JE, et al. Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia. J Thorac Cardiovasc Surg. 2004;127(5):1262-1269.