Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation

Journal of Cellular and Molecular Medicine

Volumn 20, Issue 5, 2016, Pages 980-986

  Navarro, Rocío ^a   Delgado Wicke, Pablo ^a   Nuñez Prado, Natalia ^a   Compte, Marta ^a   Blanco Toribio, Ana ^a   Nuñez, Gabriel ^b   Álvarez Vallina, Luis ^a,c   Sanz, Laura ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^b UNIVERSITY OF MICHIGAN   (United States)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

Inflammation; Lipopolysaccharide; NOD1; Peptidoglycan; Pericyte; TLR4; Vascular biology

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NOD1 PROTEIN, HUMAN; NOD2 PROTEIN, HUMAN; PEPTIDOGLYCAN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE 2; RIPK2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

AGONIST; ARTICLE; BRAIN PERICYTE; C12 IE DAP AGONIST; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; VASCULITIS; WESTERN BLOTTING; BIOSYNTHESIS; BRAIN; BRAIN ARTERY; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; METABOLISM; PERICYTE; PRIMARY CELL CULTURE; SECRETION (PROCESS); VASCULARIZATION;

BRAIN; CEREBRAL ARTERIES; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; NF-KAPPA B; NOD1 SIGNALING ADAPTOR PROTEIN; NOD2 SIGNALING ADAPTOR PROTEIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDOGLYCAN; PERICYTES; PRIMARY CELL CULTURE; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASE 2; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84959299256     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12804     Document Type: Article

References (16)

1. Armulik A, Genové G, Betsholtz C. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell. 2011; 21: 193-215.
2. Kovac A, Erickson MA, Banks WA. Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J Neuroinflammation. 2011; 8: 139.
3. Pieper C, Marek JJ, Unterberg M, et al. Brain capillary pericytes contribute to the immune defense in response to cytokines or LPS in vitro. Brain Res. 2014; 1550: 1-8.
4. Jansson D, Rustenhoven J, Feng S, et al. A role for human brain pericytes in neuroinflammation. J Neuroinflammation. 2014; 11: 104.
5. Guijarro-Muñoz I, Compte M, Álvarez-Cienfuegos A, et al. Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes. J Biol Chem. 2014; 289: 2457-68.
6. Caruso R, Warner N, Inohara N, et al. NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity. 2014; 41: 898-908.
7. Philpott DJ, Sorbara MT, Robertson SJ, et al. NOD proteins: regulators of inflammation in health and disease. Nat Rev Immunol. 2014; 14: 9-23.
8. Gatheral T, Reed DM, Moreno L, et al. A key role for the endothelium in NOD1 mediated vascular inflammation: comparison to TLR4 responses. PLoS ONE. 2012; 7: e42386.
9. Nishio H, Kanno S, Onoyama S, et al. Nod1 ligands induce site-specific vascular inflammation. Arterioscler Thromb Vasc Biol. 2011; 31: 1093-9.
10. Chamaillard M, Hashimoto M, Horie Y, et al. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol. 2003; 4: 702-7.
11. Guijarro-Muñoz I, Cuesta AM, Alvarez-Cienfuegos A, et al. The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. Exp Cell Res. 2012; 318: 371-8.
12. Harder J, Núñez G. Functional expression of the intracellular pattern recognition receptor NOD1 in human keratinocytes. J Invest Dermatol. 2009; 129: 1299-302.
13. Kobayashi K, Inohara N, Hernandez LD, et al. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature. 2002; 416: 194-9.
14. Windheim M, Lang C, Peggie M, et al. Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem J. 2007; 404: 179-90.
15. Park J-H, Kim Y-G, McDonald C, et al. RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol. 2007; 178: 2380-6.
16. Selvanantham T, Escalante NK, Cruz Tleugabulova M, et al. Nod1 and Nod2 enhance TLR-mediated invariant NKT cell activation during bacterial infection. J Immunol. 2013; 191: 5646-54.