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Volumn 39, Issue 1-2, 2016, Pages 34-40

Genomic features: Impact on pathogenesis and treatment of chronic lymphocytic leukemia

Author keywords

Chronic lymphocytic leukaemia; Cytogenetics; Gene mutations; Prognostic factors

Indexed keywords

ATM PROTEIN; CD20 ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; NOTCH1 RECEPTOR; PROTEIN P53; SPLICING FACTOR 3 SUBUNIT 1 PROTEIN; UNCLASSIFIED DRUG; GENETIC MARKER; TUMOR MARKER; TUMOR PROTEIN;

EID: 84959252774     PISSN: 22965270     EISSN: 22965262     Source Type: Journal    
DOI: 10.1159/000443906     Document Type: Review
Times cited : (5)

References (50)
  • 1
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Döhner H, Stilgenbauer S, Benner A, et al.: Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910-1916.
    • (2000) N Engl J Med , vol.343 , pp. 1910-1916
    • Döhner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 2
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: A randomised, open-label, phase 3 trial
    • Hallek M, Fischer K, Fingerle-Rowson G, et al.: Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010; 376: 1164-1174.
    • (2010) Lancet , vol.376 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3
  • 3
    • 84901408966 scopus 로고    scopus 로고
    • Gene mutations and treatment outcome in chronic lymphocytic leukemia: Results from the CLL8 trial
    • Stilgenbauer S, Schnaiter A, Paschka P, et al.: Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial. Blood 2014; 123: 3247-3254.
    • (2014) Blood , vol.123 , pp. 3247-3254
    • Stilgenbauer, S.1    Schnaiter, A.2    Paschka, P.3
  • 4
    • 80755127112 scopus 로고    scopus 로고
    • Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia
    • Wierda WG, O'Brien S, Wang X, et al.: Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia. J Clin Oncol 2011; 29: 4088-4095.
    • (2011) J Clin Oncol , vol.29 , pp. 4088-4095
    • Wierda, W.G.1    O'Brien, S.2    Wang, X.3
  • 5
    • 84907200622 scopus 로고    scopus 로고
    • Entering the era of targeted therapy for chronic lymphocytic leukemia: Impact on the practicing clinician
    • Byrd JC, Jones JJ, Woyach JA, et al.: Entering the era of targeted therapy for chronic lymphocytic leukemia: impact on the practicing clinician. J Clin Oncol Off J Am Soc Clin Oncol 2014; 32: 3039-3047.
    • (2014) J Clin Oncol off J Am Soc Clin Oncol , vol.32 , pp. 3039-3047
    • Byrd, J.C.1    Jones, J.J.2    Woyach, J.A.3
  • 6
    • 84945302209 scopus 로고    scopus 로고
    • Mutations driving CLL and their evolution in progression and relapse
    • Landau DA, Tausch E, Taylor-Weiner AN, et al.: Mutations driving CLL and their evolution in progression and relapse. Nature 2015; 526: 525-530.
    • (2015) Nature , vol.526 , pp. 525-530
    • Landau, D.A.1    Tausch, E.2    Taylor-Weiner, A.N.3
  • 7
    • 84945248976 scopus 로고    scopus 로고
    • Non-coding recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, Beá S, Valdés-Mas R, et al.: Non-coding recurrent mutations in chronic lymphocytic leukaemia. Nature 2015; 526: 519-524.
    • (2015) Nature , vol.526 , pp. 519-524
    • Puente, X.S.1    Beá, S.2    Valdés-Mas, R.3
  • 8
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, et al.: Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848-1854.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3
  • 9
    • 0037103212 scopus 로고    scopus 로고
    • V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia
    • Kröber A, Seiler T, Benner A, et al.: V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 2002; 100: 1410-1416.
    • (2002) Blood , vol.100 , pp. 1410-1416
    • Kröber, A.1    Seiler, T.2    Benner, A.3
  • 10
    • 84856260422 scopus 로고    scopus 로고
    • Defining the prognosis of early stage chronic lymphocytic leukaemia patients
    • Pepper C, Majid A, Lin TT, et al.: Defining the prognosis of early stage chronic lymphocytic leukaemia patients. Br J Haematol 2012; 156: 499-507.
    • (2012) Br J Haematol , vol.156 , pp. 499-507
    • Pepper, C.1    Majid, A.2    Lin, T.T.3
  • 12
    • 84866152172 scopus 로고    scopus 로고
    • Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling
    • Dühren-von Minden M, Übelhart R, Schneider D, et al.: Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 2012; 489: 309-312.
    • (2012) Nature , vol.489 , pp. 309-312
    • Dühren-Von Minden, M.1    Übelhart, R.2    Schneider, D.3
  • 13
    • 84879748062 scopus 로고    scopus 로고
    • Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
    • Byrd JC, Furman RR, Coutre SE, et al.: Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 2013; 369: 32-42.
    • (2013) N Engl J Med , vol.369 , pp. 32-42
    • Byrd, J.C.1    Furman, R.R.2    Coutre, S.E.3
  • 14
    • 84896692766 scopus 로고    scopus 로고
    • Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
    • Furman RR, Sharman JP, Coutre SE, et al.: Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 2014; 370: 997-1007.
    • (2014) N Engl J Med , vol.370 , pp. 997-1007
    • Furman, R.R.1    Sharman, J.P.2    Coutre, S.E.3
  • 15
    • 84959212620 scopus 로고    scopus 로고
    • Venetoclax (ABT-199/ GDC-0199) combined with rituximab induces deep responses in patients with relapsed/refractory chronic lymphocytic leukemia
    • abstr S431
    • Roberts AW, Ma S, Brander D, et al. Venetoclax (ABT-199/ GDC-0199) combined with rituximab induces deep responses in patients with relapsed/refractory chronic lymphocytic leukemia. EHA Ann Meet 2015;abstr S431.
    • (2015) EHA Ann Meet
    • Roberts, A.W.1    Ma, S.2    Brander, D.3
  • 16
    • 13544275555 scopus 로고    scopus 로고
    • Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: The lesson of the IGHV3-21 gene
    • Ghia P, Stamatopoulos K, Belessi C, et al.: Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene. Blood 2005; 105: 1678-1685.
    • (2005) Blood , vol.105 , pp. 1678-1685
    • Ghia, P.1    Stamatopoulos, K.2    Belessi, C.3
  • 17
    • 84878396846 scopus 로고    scopus 로고
    • SF3B1 mutations in chronic lymphocytic leukemia
    • Wan Y, Wu CJ: SF3B1 mutations in chronic lymphocytic leukemia. Blood 2013; 121: 4627-4634.
    • (2013) Blood , vol.121 , pp. 4627-4634
    • Wan, Y.1    Wu, C.J.2
  • 18
    • 80054691036 scopus 로고    scopus 로고
    • General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL
    • Fazi C, Scarfò L, Pecciarini L, et al.: General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL. Blood 2011; 118: 6618-6625.
    • (2011) Blood , vol.118 , pp. 6618-6625
    • Fazi, C.1    Scarfò, L.2    Pecciarini, L.3
  • 19
    • 25444520537 scopus 로고    scopus 로고
    • MiR-15 and miR-16 induce apoptosis by targeting BCL2
    • Cimmino A, Calin GA, Fabbri M, et al.: miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 2005; 102: 13944-13949.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 13944-13949
    • Cimmino, A.1    Calin, G.A.2    Fabbri, M.3
  • 20
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T: Identification of novel genes coding for small expressed RNAs. Science 2001; 294: 853-858.
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 21
    • 58249117812 scopus 로고    scopus 로고
    • The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype
    • Dicker F, Herholz H, Schnittger S, et al.: The detection of TP53 mutations in chronic lymphocytic leukemia independently predicts rapid disease progression and is highly correlated with a complex aberrant karyotype. Leukemia 2008; 23: 117-124.
    • (2008) Leukemia , vol.23 , pp. 117-124
    • Dicker, F.1    Herholz, H.2    Schnittger, S.3
  • 22
    • 84943579968 scopus 로고    scopus 로고
    • Complex karyotype is a stronger predictor than del(17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinibbased regimens
    • Thompson PA, O'Brien SM, Wierda WG, et al.: Complex karyotype is a stronger predictor than del(17p) for an inferior outcome in relapsed or refractory chronic lymphocytic leukemia patients treated with ibrutinibbased regimens. Cancer 2015; 121: 3612-3621.
    • (2015) Cancer , vol.121 , pp. 3612-3621
    • Thompson, P.A.1    O'Brien, S.M.2    Wierda, W.G.3
  • 23
    • 84870763388 scopus 로고    scopus 로고
    • High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations
    • Edelmann J, Holzmann K, Miller F, et al.: High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations. Blood 2012; 120: 4783-4794.
    • (2012) Blood , vol.120 , pp. 4783-4794
    • Edelmann, J.1    Holzmann, K.2    Miller, F.3
  • 24
    • 79957949229 scopus 로고    scopus 로고
    • Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: Results from the LRF CLL4 trial
    • Gonzalez D, Martinez P, Wade R, et al.: Mutational status of the TP53 gene as a predictor of response and survival in patients with chronic lymphocytic leukemia: results from the LRF CLL4 trial. J Clin Oncol Off J Am Soc Clin Oncol 2011; 29: 2223-2229.
    • (2011) J Clin Oncol off J Am Soc Clin Oncol , vol.29 , pp. 2223-2229
    • Gonzalez, D.1    Martinez, P.2    Wade, R.3
  • 26
    • 80052716066 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • on behalf of the ESMO Guidelines Working Group
    • Eichhorst B, Dreyling M, Robak T, et al.; on behalf of the ESMO Guidelines Working Group: Chronic lymphocytic leukemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2011; 22:vi50-vi54.
    • (2011) Ann Oncol , vol.22 , pp. vi50-vi54
    • Eichhorst, B.1    Dreyling, M.2    Robak, T.3
  • 27
    • 79960353160 scopus 로고    scopus 로고
    • Analysis of the chronic lymphocytic leukemia coding genome: Role of NOTCH1 mutational activation
    • Fabbri G, Rasi S, Rossi D, et al.: Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med 2011; 208: 1389-1401.
    • (2011) J Exp Med , vol.208 , pp. 1389-1401
    • Fabbri, G.1    Rasi, S.2    Rossi, D.3
  • 28
    • 84874102335 scopus 로고    scopus 로고
    • Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
    • Landau DA, Carter SL, Stojanov P, et al.: Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 2013; 152: 714-726.
    • (2013) Cell , vol.152 , pp. 714-726
    • Landau, D.A.1    Carter, S.L.2    Stojanov, P.3
  • 29
    • 84555171449 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
    • Quesada V, Conde L, Villamor N, et al.: Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet 2012; 44: 47-52.
    • (2012) Nat Genet , vol.44 , pp. 47-52
    • Quesada, V.1    Conde, L.2    Villamor, N.3
  • 30
    • 84855370035 scopus 로고    scopus 로고
    • SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
    • Wang L, Lawrence MS, Wan Y, et al.: SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med 2011; 365: 2497-2506.
    • (2011) N Engl J Med , vol.365 , pp. 2497-2506
    • Wang, L.1    Lawrence, M.S.2    Wan, Y.3
  • 31
    • 84922529491 scopus 로고    scopus 로고
    • Recurrent mutations refine prognosis in chronic lymphocytic leukemia
    • Baliakas P, Hadzidimitriou A, Sutton L-A, et al.: Recurrent mutations refine prognosis in chronic lymphocytic leukemia. Leukemia 2015; 29: 329-336.
    • (2015) Leukemia , vol.29 , pp. 329-336
    • Baliakas, P.1    Hadzidimitriou, A.2    Sutton, L.-A.3
  • 32
    • 84891866590 scopus 로고    scopus 로고
    • SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients
    • Jeromin S, Weissmann S, Haferlach C, et al.: SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients. Leukemia 2014; 28: 108-117.
    • (2014) Leukemia , vol.28 , pp. 108-117
    • Jeromin, S.1    Weissmann, S.2    Haferlach, C.3
  • 33
    • 84855854025 scopus 로고    scopus 로고
    • Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia
    • Rossi D, Rasi S, Fabbri G, et al.: Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 2012; 119: 521-529.
    • (2012) Blood , vol.119 , pp. 521-529
    • Rossi, D.1    Rasi, S.2    Fabbri, G.3
  • 34
    • 84255160977 scopus 로고    scopus 로고
    • Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: Association with progression and fludarabine-refractoriness
    • Rossi D, Bruscaggin A, Spina V, et al.: Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. Blood 2011; 118: 6904-6908.
    • (2011) Blood , vol.118 , pp. 6904-6908
    • Rossi, D.1    Bruscaggin, A.2    Spina, V.3
  • 35
    • 84887204270 scopus 로고    scopus 로고
    • NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: Results from the CLL2H trial of the GCLLSG
    • Schnaiter A, Paschka P, Rossi M, et al.: NOTCH1, SF3B1, and TP53 mutations in fludarabine-refractory CLL patients treated with alemtuzumab: results from the CLL2H trial of the GCLLSG. Blood 2013; 122: 1266-1270.
    • (2013) Blood , vol.122 , pp. 1266-1270
    • Schnaiter, A.1    Paschka, P.2    Rossi, M.3
  • 36
    • 34447530283 scopus 로고    scopus 로고
    • Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): A randomised controlled trial
    • Catovsky D, Richards S, Matutes E, et al.: Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial. Lancet Lond Engl 2007; 370: 230-239.
    • (2007) Lancet Lond Engl , vol.370 , pp. 230-239
    • Catovsky, D.1    Richards, S.2    Matutes, E.3
  • 37
    • 80054010617 scopus 로고    scopus 로고
    • Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
    • Papaemmanuil E, Cazzola M, Boultwood J, et al.: Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med 2011; 365: 1384-1395.
    • (2011) N Engl J Med , vol.365 , pp. 1384-1395
    • Papaemmanuil, E.1    Cazzola, M.2    Boultwood, J.3
  • 38
    • 84885615233 scopus 로고    scopus 로고
    • SF3B1 mutations are associated with alternative splicing in uveal melanoma
    • Furney SJ, Pedersen M, Gentien D, et al.: SF3B1 mutations are associated with alternative splicing in uveal melanoma. Cancer Discov 2013; 3: 1122-1129.
    • (2013) Cancer Discov , vol.3 , pp. 1122-1129
    • Furney, S.J.1    Pedersen, M.2    Gentien, D.3
  • 39
    • 84929291816 scopus 로고    scopus 로고
    • The impact of SF3B1 mutations in CLL on the DNA-damage response
    • Te Raa GD, Derks IA, Navrkalova V, et al.: The impact of SF3B1 mutations in CLL on the DNA-damage response. Leukemia 2015; 29: 1133-1142.
    • (2015) Leukemia , vol.29 , pp. 1133-1142
    • Te Raa, G.D.1    Derks, I.A.2    Navrkalova, V.3
  • 40
    • 84872469222 scopus 로고    scopus 로고
    • The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial
    • Oscier DG, Rose-Zerilli MJJ, Winkelmann N, et al.: The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial. Blood 2013; 121: 468-475.
    • (2013) Blood , vol.121 , pp. 468-475
    • Oscier, D.G.1    Rose-Zerilli, M.J.J.2    Winkelmann, N.3
  • 41
    • 79960036578 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
    • Puente XS, Pinyol M, Quesada V, et al.: Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. Nature 2011; 475: 101-105.
    • (2011) Nature , vol.475 , pp. 101-105
    • Puente, X.S.1    Pinyol, M.2    Quesada, V.3
  • 42
    • 84877635463 scopus 로고    scopus 로고
    • NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome
    • Villamor N, Conde L, Martínez-Trillos A, et al.: NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome. Leukemia 2013; 27: 1100-1106.
    • (2013) Leukemia , vol.27 , pp. 1100-1106
    • Villamor, N.1    Conde, L.2    Martínez-Trillos, A.3
  • 43
    • 84890436856 scopus 로고    scopus 로고
    • Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): A study on 852 patients
    • Weissmann S, Roller A, Jeromin S, et al.: Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patients. Leukemia 2013; 27: 2393-2396.
    • (2013) Leukemia , vol.27 , pp. 2393-2396
    • Weissmann, S.1    Roller, A.2    Jeromin, S.3
  • 44
    • 84929082256 scopus 로고    scopus 로고
    • NOTCH1 mutation and treatment outcome in CLL patients treated with chlorambucil (Chl) or ofatumumab-Chl (O-Chl): Results from the phase III study complement 1 (OMB110911)
    • Tausch E, Schlenk RF, Kless S, et al.: NOTCH1 mutation and treatment outcome in CLL patients treated with chlorambucil (Chl) or ofatumumab-Chl (O-Chl): results from the phase III study complement 1 (OMB110911). Blood 2013; 122: 527-527.
    • (2013) Blood , vol.122 , pp. 527
    • Tausch, E.1    Schlenk, R.F.2    Kless, S.3
  • 45
    • 84871798242 scopus 로고    scopus 로고
    • Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial
    • Skowronska A, Parker A, Ahmed G, et al.: Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial. J Clin Oncol Off J Am Soc Clin Oncol 2012; 30: 4524-4532.
    • (2012) J Clin Oncol off J Am Soc Clin Oncol , vol.30 , pp. 4524-4532
    • Skowronska, A.1    Parker, A.2    Ahmed, G.3
  • 46
    • 84858859064 scopus 로고    scopus 로고
    • Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
    • Rossi D, Fangazio M, Rasi S, et al.: Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood 2012; 119: 2854-2862.
    • (2012) Blood , vol.119 , pp. 2854-2862
    • Rossi, D.1    Fangazio, M.2    Rasi, S.3
  • 47
    • 84897434576 scopus 로고    scopus 로고
    • ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: Data from the UK LRF CLL4 trial
    • Rose-Zerilli MJJ, Forster J, Parker H, et al.: ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial. Haematologica 2014; 99: 736-742.
    • (2014) Haematologica , vol.99 , pp. 736-742
    • Rose-Zerilli, M.J.J.1    Forster, J.2    Parker, H.3
  • 48
    • 84906908742 scopus 로고    scopus 로고
    • Acquired initiating mutations in early hematopoietic cells of CLL patients
    • Damm F, Mylonas E, Cosson A, et al.: Acquired initiating mutations in early hematopoietic cells of CLL patients. Cancer Discov 2014; 4: 1088-1101.
    • (2014) Cancer Discov , vol.4 , pp. 1088-1101
    • Damm, F.1    Mylonas, E.2    Cosson, A.3
  • 49
    • 84874428346 scopus 로고    scopus 로고
    • Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia
    • Rossi D, Rasi S, Spina V, et al.: Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood 2013; 121: 1403-1412.
    • (2013) Blood , vol.121 , pp. 1403-1412
    • Rossi, D.1    Rasi, S.2    Spina, V.3
  • 50
    • 84903971364 scopus 로고    scopus 로고
    • Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia
    • Pflug N, Bahlo J, Shanafelt TD, et al.: Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia. Blood 2014; 124: 49-62.
    • (2014) Blood , vol.124 , pp. 49-62
    • Pflug, N.1    Bahlo, J.2    Shanafelt, T.D.3


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