메뉴 건너뛰기




Volumn 11, Issue 2, 2016, Pages

A murine, bispecific monoclonal antibody simultaneously recognizing β-Glucan and MP65 determinants in Candida species

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BETA D GLUCAN; 1,6 BETA D GLUCAN; BETA GLUCAN; BIOLOGICAL MARKER; LAMINARAN; MANNOPROTEIN; MONOCLONAL ANTIBODY; MP65 BGLU MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; BISPECIFIC ANTIBODY; EPITOPE; FUNGAL PROTEIN; FUNGUS ANTIBODY; FUNGUS ANTIGEN; MANNOPROTEINS; MEMBRANE PROTEIN;

EID: 84959244365     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0148714     Document Type: Article
Times cited : (10)

References (47)
  • 1
    • 84891715342 scopus 로고    scopus 로고
    • Invasive candidiasis as a cause of sepsis in the critically ill patient
    • PMID: 24157707
    • Delaloye J, Calandra T. Invasive candidiasis as a cause of sepsis in the critically ill patient. Virulence. 2014; 5: 161-169. doi:10.4161/viru.26187PMID: 24157707.
    • (2014) Virulence. , vol.5 , pp. 161-169
    • Delaloye, J.1    Calandra, T.2
  • 2
    • 84875994691 scopus 로고    scopus 로고
    • Finding the "missing 50%" of invasive candidiasis: How nonculture diagnostics will improve understanding of disease spectrum and transform patient, care
    • PMID: 23315320
    • Clancy CJ, Nguyen MH. Finding the "missing 50%" of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care. Clin Infect Dis. 2013; 56: 1284-1292. doi:10.1093/cid/cit006PMID: 23315320.
    • (2013) Clin Infect Dis. , vol.56 , pp. 1284-1292
    • Clancy, C.J.1    Nguyen, M.H.2
  • 3
    • 74449092600 scopus 로고    scopus 로고
    • Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections
    • PMID: 19836856
    • Moran C, Grussemeyer CA, Spalding JR, Benjamin DK Jr, Reed SD. Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections. Am J Infect Control. 2010; 38: 78-80. doi:10.1016/j.ajic.2009.06.014 PMID: 19836856.
    • (2010) Am J Infect Control , vol.38 , pp. 78-80
    • Moran, C.1    Grussemeyer, C.A.2    Spalding, J.R.3    Benjamin, D.K.4    Reed, S.D.5
  • 4
    • 24144483474 scopus 로고    scopus 로고
    • Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: A potential risk factor for hospital mortality
    • PMID: 16127033
    • Morrell M, Fraser VJ, Kollef MH. Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: A potential risk factor for hospital mortality. Antimicrob Agents Chemother. 2005; 49: 3640-3645. PMID: 16127033.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3640-3645
    • Morrell, M.1    Fraser, V.J.2    Kollef, M.H.3
  • 5
    • 33745313876 scopus 로고    scopus 로고
    • Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: A multi-institutional, study
    • PMID: 16758414
    • Garey KW, Rege M, Pai MP, Mingo DE, Suda KJ, Turpin RS, et al. Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: A multi-institutional study. Clin Infect Dis. 2006; 43: 25-31. PMID: 16758414.
    • (2006) Clin Infect Dis , vol.43 , pp. 25-31
    • Garey, K.W.1    Rege, M.2    Pai, M.P.3    Mingo, D.E.4    Suda, K.J.5    Turpin, R.S.6
  • 6
    • 0025142095 scopus 로고
    • Gene transfer by retrovirusderived shuttle vectors in the generation of murine bispecific MAbs
    • PMID: 2401381
    • De Monte L, Nistico P, Tecce R, Dellabona P, Momo M, Tarditi L, et al. Gene transfer by retrovirusderived shuttle vectors in the generation of murine bispecific MAbs. Dev Biol Stand. 1990; 71: 15-22. PMID: 2401381.
    • (1990) Dev Biol Stand , vol.71 , pp. 15-22
    • De Monte, L.1    Nistico, P.2    Tecce, R.3    Dellabona, P.4    Momo, M.5    Tarditi, L.6
  • 7
    • 0027488404 scopus 로고
    • Cell surface receptors and bispecific monoclonal antibodies: The link between basic science and medical oncology
    • PMID: 8396823
    • Malavasi F, De Monte LB, Funaro A, Magrini E, Bonino LD, Momo M, et al. Cell surface receptors and bispecific monoclonal antibodies: the link between basic science and medical oncology. Year Immunol. 1993; 7: 74-80. PMID: 8396823.
    • (1993) Year Immunol , vol.7 , pp. 74-80
    • Malavasi, F.1    De Monte, L.B.2    Funaro, A.3    Magrini, E.4    Bonino, L.D.5    Momo, M.6
  • 8
    • 0027143341 scopus 로고
    • Real-time kinetic analysis applied to the production of bispecific monoclonal antibodies for radioimmunodetection of cancer
    • PMID: 8123875
    • Horenstein AL, Poiesi C, DeMonte L, Camagna M, Mariani M, Albertini A, et al. Real-time kinetic analysis applied to the production of bispecific monoclonal antibodies for radioimmunodetection of cancer. Int J Clin Lab Res. 1993; 23: 199-205. PMID: 8123875.
    • (1993) Int J Clin Lab Res. , vol.23 , pp. 199-205
    • Horenstein, A.L.1    Poiesi, C.2    DeMonte, L.3    Camagna, M.4    Mariani, M.5    Albertini, A.6
  • 9
    • 0026722964 scopus 로고
    • Cell retargeting by bispecific monoclonal antibodies. Evidence of bypass of intratumor susceptibility to cell lysis in human melanoma
    • PMID: 1387883
    • Nistico P, Mortarini R, De Monte LB, Mazzocchi A, Mariani M, Malavasi F, et al. Cell retargeting by bispecific monoclonal antibodies. Evidence of bypass of intratumor susceptibility to cell lysis in human melanoma. J Clin Invest. 1992; 90: 1093-1099. PMID: 1387883.
    • (1992) J Clin Invest , vol.90 , pp. 1093-1099
    • Nistico, P.1    Mortarini, R.2    De, M.L.B.3    Mazzocchi, A.4    Mariani, M.5    Malavasi, F.6
  • 10
    • 0025237155 scopus 로고
    • Gene transfer by retrovirusderived shuttle vectors in the generation of murine bispecific monoclonal antibodies
    • PMID: 2326256
    • DeMonte LB, Nistico P, Tecce R, Dellabona P, Momo M, Anichini A, et al. Gene transfer by retrovirusderived shuttle vectors in the generation of murine bispecific monoclonal antibodies. Proc Natl Acad Sci U S A. 1990; 87: 2941-2945. PMID: 2326256.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 2941-2945
    • DeMonte, L.B.1    Nistico, P.2    Tecce, R.3    Dellabona, P.4    Momo, M.5    Anichini, A.6
  • 11
    • 84858257263 scopus 로고    scopus 로고
    • Dual targeting strategies with bispecific antibodies
    • PMID: 22453100
    • Kontermann RE. Dual targeting strategies with bispecific antibodies. MAbs. 2012; 4: 182-197. doi:10.4161/mabs.4.2.19000 PMID: 22453100.
    • (2012) MAbs , vol.4 , pp. 182-197
    • Kontermann, R.E.1
  • 12
    • 84886099419 scopus 로고    scopus 로고
    • A tale of two specificities: Bispecific antibodies for therapeutic and diagnostic applications
    • PMID: 24094861
    • Byrne H, Conroy PJ, Whisstock JC, O'Kennedy RJ. A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications. Trends Biotechnol. 2013; 31: 621-632. doi:10.1016/j.tibtech.2013.08.007PMID: 24094861.
    • (2013) Trends Biotechnol , vol.31 , pp. 621-632
    • Byrne, H.1    Conroy, P.J.2    Whisstock, J.C.3    O'Kennedy, R.J.4
  • 13
    • 65449157222 scopus 로고    scopus 로고
    • Protection by anti-betaglucan antibodies is associated with restricted beta-1, 3 glucan binding specificity and inhibition of fungal growth and adherence
    • PMID: 19399183
    • Torosantucci A, Chiani P, Bromuro C, De Bernardis F, Palma AS, Liu Y, et al. Protection by anti-betaglucan antibodies is associated with restricted beta-1, 3 glucan binding specificity and inhibition of fungal growth and adherence. PLoS One. 2009; 4: e5392. doi:10.1371/journal.pone.0005392 PMID: 19399183.
    • (2009) PLoS One , vol.4 , pp. e5392
    • Torosantucci, A.1    Chiani, P.2    Bromuro, C.3    De Bernardis, F.4    Palma, A.S.5    Liu, Y.6
  • 15
    • 0027257474 scopus 로고
    • Identification of a 65-kDa mannoprotein as a main target of human cell-mediated immune response to Candida albicans
    • PMID: 8335981
    • Torosantucci A, Bromuro C, Gomez MJ, Ausiello CM, Urbani F, Cassone A. Identification of a 65-kDa mannoprotein as a main target of human cell-mediated immune response to Candida albicans. J Infect Dis. 1993; 168: 427-435. PMID: 8335981.
    • (1993) J Infect Dis , vol.168 , pp. 427-435
    • Torosantucci, A.1    Bromuro, C.2    Gomez, M.J.3    Ausiello, C.M.4    Urbani, F.5    Cassone, A.6
  • 16
    • 0030012943 scopus 로고    scopus 로고
    • Purification and biochemical characterization of a 65-kilodalton mannoprotein (MP65), a main target of anti-Candida cell-mediated immune responses in humans
    • PMID: 8698482
    • Gomez MJ, Torosantucci A, Arancia S, Maras B, Parisi L, Cassone A. Purification and biochemical characterization of a 65-kilodalton mannoprotein (MP65), a main target of anti-Candida cell-mediated immune responses in humans. Infect Immun. 1996; 64: 2577-2584. PMID: 8698482.
    • (1996) Infect Immun , vol.64 , pp. 2577-2584
    • Gomez, M.J.1    Torosantucci, A.2    Arancia, S.3    Maras, B.4    Parisi, L.5    Cassone, A.6
  • 17
    • 24344482904 scopus 로고    scopus 로고
    • Purification of clinical-grade monoclonal antibodies by chromatographic methods
    • PMID: 16082036
    • Horenstein AL, Durelli I, Malavasi F. Purification of clinical-grade monoclonal antibodies by chromatographic methods. Methods Mol Biol. 2005; 308: 191-208. PMID: 16082036.
    • (2005) Methods Mol Biol. , vol.308 , pp. 191-208
    • Horenstein, A.L.1    Durelli, I.2    Malavasi, F.3
  • 18
    • 0037377310 scopus 로고    scopus 로고
    • Design and scaleup of downstream processing of monoclonal antibodies for cancer therapy: From research to clinical proof of principle
    • PMID: 12667674
    • Horenstein AL, Crivellin F, Funaro A, Said M, Malavasi F. Design and scaleup of downstream processing of monoclonal antibodies for cancer therapy: from research to clinical proof of principle. J Immunol Methods. 2003; 275: 99-112. PMID: 12667674.
    • (2003) J Immunol Methods , vol.275 , pp. 99-112
    • Horenstein, A.L.1    Crivellin, F.2    Funaro, A.3    Said, M.4    Malavasi, F.5
  • 19
    • 79960650492 scopus 로고    scopus 로고
    • A novel redox method for rapid production of functional bi-specific antibodies for use in early pilot studies
    • PMID: 21811628
    • Carlring J, De Leenheer E, Heath AW. A novel redox method for rapid production of functional bi-specific antibodies for use in early pilot studies. PLoS One. 2011; 6: e22533. doi:10.1371/journal.pone.0022533 PMID: 21811628.
    • (2011) PLoS One , vol.6 , pp. e22533
    • Carlring, J.1    De Leenheer, E.2    Heath, A.W.3
  • 20
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • PMID: 5432063
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227: 680-685. PMID: 5432063.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 21
    • 84981776413 scopus 로고
    • Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion
    • PMID: 13079779
    • Ouchterlony O. Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. Acta Pathol Microbiol Scand. 1953; 32: 230-240. PMID: 13079779.
    • (1953) Acta Pathol Microbiol Scand , vol.32 , pp. 230-240
    • Ouchterlony, O.1
  • 23
    • 0032911547 scopus 로고    scopus 로고
    • Development of a 96-well enzyme-linked solid-phase assay for beta-glucanase and xylanase
    • PMID: 10552447
    • Wang G, Marquardt RR, Xiao H, Zhang Z. Development of a 96-well enzyme-linked solid-phase assay for beta-glucanase and xylanase. J Agric Food Chem. 1999; 47: 1262-1267. PMID: 10552447.
    • (1999) J Agric Food Chem , vol.47 , pp. 1262-1267
    • Wang, G.1    Marquardt, R.R.2    Xiao, H.3    Zhang, Z.4
  • 24
    • 70350714584 scopus 로고    scopus 로고
    • New approach for diagnosis of candidemia based on detection of a 65-kilodalton antigen
    • PMID: 19776195
    • Berzaghi R, Colombo AL, Machado AM, de Camargo ZP. New approach for diagnosis of candidemia based on detection of a 65-kilodalton antigen. Clin Vaccine Immunol. 2009; 16: 1538-1545. doi:10.1128/CVI.00176-09 PMID: 19776195.
    • (2009) Clin Vaccine Immunol , vol.16 , pp. 1538-1545
    • Berzaghi, R.1    Colombo, A.L.2    Machado, A.M.3    De Camargo, Z.P.4
  • 25
    • 0026572365 scopus 로고
    • Selective high-performance liquid chromatographic purification of bispecific monoclonal antibodies
    • PMID: 1618986
    • Tarditi L, Camagna M, Parisi A, Vassarotto C, DeMonte LB, Letarte M, et al. Selective high-performance liquid chromatographic purification of bispecific monoclonal antibodies. J Chromatogr. 1992; 599: 13-20. PMID: 1618986.
    • (1992) J Chromatogr. , vol.599 , pp. 13-20
    • Tarditi, L.1    Camagna, M.2    Parisi, A.3    Vassarotto, C.4    DeMonte, L.B.5    Letarte, M.6
  • 26
    • 84907131955 scopus 로고
    • Differential release of an immunodominant 65 kDa mannoprotein antigen from yeast and mycelial forms of Candida albicans
    • PMID: 7738727
    • Bromuro C, Torosantucci A, Gomez MJ, Urbani F, Cassone A. Differential release of an immunodominant 65 kDa mannoprotein antigen from yeast and mycelial forms of Candida albicans. J Med Vet Mycol. 1994; 32: 447-459. PMID: 7738727.
    • (1994) J Med Vet Mycol , vol.32 , pp. 447-459
    • Bromuro, C.1    Torosantucci, A.2    Gomez, M.J.3    Urbani, F.4    Cassone, A.5
  • 27
    • 84910673427 scopus 로고    scopus 로고
    • A multifunctional bispecific antibody protects against Pseudomonas aeruginosa
    • PMID: 25391481
    • DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, et al. A multifunctional bispecific antibody protects against Pseudomonas aeruginosa. Sci Transl Med. 2014; 6: 262ra155. doi:10.1126/scitranslmed.3009655 PMID: 25391481.
    • (2014) Sci Transl, Med , vol.6 , pp. 262ra155
    • DiGiandomenico, A.1    Keller, A.E.2    Gao, C.3    Rainey, G.J.4    Warrener, P.5    Camara, M.M.6
  • 28
    • 0035882036 scopus 로고    scopus 로고
    • Targeting of Pseudomonas aeruginosa in the bloodstream with bispecific monoclonal antibodies
    • PMID: 11490011
    • Lindorfer MA, Nardin A, Foley PL, Solga MD, Bankovich AJ, Martin EN, et al. Targeting of Pseudomonas aeruginosa in the bloodstream with bispecific monoclonal antibodies. J Immunol. 2001; 167: 2240- 2249. PMID: 11490011.
    • (2001) J Immunol. , vol.167 , pp. 2240-2249
    • Lindorfer, M.A.1    Nardin, A.2    Foley, P.L.3    Solga, M.D.4    Bankovich, A.J.5    Martin, E.N.6
  • 29
    • 33845641402 scopus 로고    scopus 로고
    • Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis
    • PMID: 17152019
    • De Bernardis F, Liu H, O'Mahony R, La Valle R, Bartollino S, Sandini S, et al. Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis. J Infect Dis. 2007; 195: 149-157. PMID: 17152019.
    • (2007) J Infect Dis , vol.195 , pp. 149-157
    • De Bernardis, F.1    Liu, H.2    O'Mahony, R.3    La Valle, R.4    Bartollino, S.5    Sandini, S.6
  • 30
    • 84907102875 scopus 로고    scopus 로고
    • A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice
    • PMID: 24683195
    • Yang Z, Schmidt D, Liu W, Li S, Shi L, Sheng J, et al. A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice. J Infect Dis. 2014; 210: 964-972. doi:10.1093/infdis/jiu196 PMID: 24683195.
    • (2014) J Infect Dis , vol.210 , pp. 964-972
    • Yang, Z.1    Schmidt, D.2    Liu, W.3    Li, S.4    Shi, L.5    Sheng, J.6
  • 32
    • 80051936633 scopus 로고    scopus 로고
    • Inhibition of anthrax toxins with a bispecific monoclonal antibody that cross reacts with edema factor as well as lethal factor of Bacillus anthracis
    • PMID: 21704379
    • Kulshreshtha P, Bhatnagar R. Inhibition of anthrax toxins with a bispecific monoclonal antibody that cross reacts with edema factor as well as lethal factor of Bacillus anthracis. Mol Immunol. 2011; 48: 1958-1965. doi:10.1016/j.molimm.2011.05.024PMID: 21704379.
    • (2011) Mol Immunol , vol.48 , pp. 1958-1965
    • Kulshreshtha, P.1    Bhatnagar, R.2
  • 33
    • 84863910949 scopus 로고    scopus 로고
    • Bispecific antibodymediated detection of the staphylococcus aureus thermonuclease
    • PMID: 22650421
    • Wagstaffe SJ, Hill KE, Williams DW, Randle BJ, Thomas DW, Stephens P, et al. Bispecific antibodymediated detection of the Staphylococcus aureus thermonuclease. Anal Chem. 2012; 84: 5876-5884. doi:10.1021/ac203403d PMID: 22650421.
    • (2012) Anal Chem , vol.84 , pp. 5876-5884
    • Wagstaffe, S.J.1    Hill, K.E.2    Williams, D.W.3    Randle, B.J.4    Thomas, D.W.5    Stephens, P.6
  • 34
    • 34548852868 scopus 로고    scopus 로고
    • Monospecific and bispecific antibodies against E. Coli O157 for diagnostics
    • PMID: 17804009
    • Guttikonda S, Tang XL, Yang BM, Armstrong GD, Suresh MR. Monospecific and bispecific antibodies against E. coli O157 for diagnostics. J Immunol Methods. 2007; 327: 1-9. PMID: 17804009.
    • (2007) J Immunol Methods , vol.327 , pp. 1-9
    • Guttikonda, S.1    Tang, X.L.2    Yang, B.M.3    Armstrong, G.D.4    Suresh, M.R.5
  • 35
    • 84857402379 scopus 로고    scopus 로고
    • A bispecific antibody based assay shows potential for detecting tuberculosis in resource constrained laboratory settings
    • PMID: 22363820
    • Sarkar S, Tang XL, Das D, Spencer JS, Lowary TL, Suresh MR. A bispecific antibody based assay shows potential for detecting tuberculosis in resource constrained laboratory settings. PLoS One. 2012; 7: e32340. doi:10.1371/journal.pone.0032340 PMID: 22363820.
    • (2012) PLoS One , vol.7 , pp. e32340
    • Sarkar, S.1    Tang, X.L.2    Das, D.3    Spencer, J.S.4    Lowary, T.L.5    Suresh, M.R.6
  • 36
    • 84903600596 scopus 로고    scopus 로고
    • Molecular and nonmolecular diagnostic methods for invasive fungal infections
    • PMID: 24982319
    • Arvanitis M, Anagnostou T, Fuchs BB, Caliendo AM, Mylonakis E. Molecular and nonmolecular diagnostic methods for invasive fungal infections. Clin Microbiol Rev. 2014; 27: 490-526. doi:10.1128/CMR.00091-13 PMID: 24982319.
    • (2014) Clin Microbiol, Rev , vol.27 , pp. 490-526
    • Arvanitis, M.1    Anagnostou, T.2    Fuchs, B.B.3    Caliendo, A.M.4    Mylonakis, E.5
  • 37
    • 0034444895 scopus 로고    scopus 로고
    • Generation of a recombinant 65-kilodalton mannoprotein, a major antigen target of cell-mediated immune response to Candida albicans
    • PMID: 11083795
    • La Valle R, Sandini S, Gomez MJ, Mondello F, Romagnoli G, Nisini R, et al. Generation of a recombinant 65-kilodalton mannoprotein, a major antigen target of cell-mediated immune response to Candida albicans. Infect Immun. 2000; 68: 6777-6784. PMID: 11083795.
    • (2000) Infect Immun , vol.68 , pp. 6777-6784
    • La, V.R.1    Sandini, S.2    Gomez, M.J.3    Mondello, F.4    Romagnoli, G.5    Nisini, R.6
  • 38
    • 84889831910 scopus 로고    scopus 로고
    • Production of stable bispecific IgG1 by controlled Fab-arm exchange: Scalability from bench to large-scale manufacturing by application of standard approaches
    • PMID: 23995617
    • Gramer MJ, van den Bremer ET, van Kampen MD, Kundu A, Kopfmann P, Etter E, et al. Production of stable bispecific IgG1 by controlled Fab-arm exchange: scalability from bench to large-scale manufacturing by application of standard approaches. MAbs. 2013; 5: 962-973. PMID: 23995617.
    • (2013) MAbs , vol.5 , pp. 962-973
    • Gramer, M.J.1    Van Den Bremer, E.T.2    Van Kampen, M.D.3    Kundu, A.4    Kopfmann, P.5    Etter, E.6
  • 39
    • 84898622988 scopus 로고    scopus 로고
    • An alternative chemical redox method for the production of bispecific antibodies: Implication in rapid detection of food borne pathogens
    • PMID: 24637674
    • Owais M, Kazmi S, Tufail S, Zubair S. An alternative chemical redox method for the production of bispecific antibodies: implication in rapid detection of food borne pathogens. PLoS One. 2014; 9: e91255. doi:10.1371/journal.pone.0091255 PMID: 24637674.
    • (2014) PLoS One , vol.9 , pp. e91255
    • Owais, M.1    Kazmi, S.2    Tufail, S.3    Zubair, S.4
  • 40
    • 84862015979 scopus 로고    scopus 로고
    • Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair
    • PMID: 22543237
    • Strop P, Ho WH, Boustany LM, Abdiche YN, Lindquist KC, Farias SE, et al. Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair. J Mol Biol. 2012; 420: 204-219. doi:10.1016/j.jmb.2012.04.020 PMID: 22543237.
    • (2012) J Mol Biol , vol.420 , pp. 204-219
    • Strop, P.1    Ho, W.H.2    Boustany, L.M.3    Abdiche, Y.N.4    Lindquist, K.C.5    Farias, S.E.6
  • 41
    • 84881460836 scopus 로고    scopus 로고
    • Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies
    • PMID: 23831709
    • Spiess C, Merchant M, Huang A, Zheng Z, Yang NY, Peng J, et al. Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies. Nat Biotechnol. 2013; 31: 753-758. doi:10.1038/nbt.2621 PMID: 23831709.
    • (2013) Nat Biotechnol , vol.31 , pp. 753-758
    • Spiess, C.1    Merchant, M.2    Huang, A.3    Zheng, Z.4    Yang, N.Y.5    Peng, J.6
  • 43
    • 38749103119 scopus 로고    scopus 로고
    • The immunoglobulin constant region contributes to affinity and specificity
    • PMID: 18191616
    • Torres M, Casadevall A. The immunoglobulin constant region contributes to affinity and specificity. Trends Immunol. 2008; 29: 91-97. doi:10.1016/j.it.2007.11.004 PMID: 18191616.
    • (2008) Trends Immunol , vol.29 , pp. 91-97
    • Torres, M.1    Casadevall, A.2
  • 44
    • 84877346936 scopus 로고    scopus 로고
    • The constant region affects antigen binding of antibodies to DNA by altering secondary structure
    • PMID: 23665381
    • Xia Y, Janda A, Eryilmaz E, Casadevall A, Putterman C. The constant region affects antigen binding of antibodies to DNA by altering secondary structure. Mol Immunol. 2013; 56: 28-37. doi:10.1016/j.molimm.2013.04.004 PMID: 23665381.
    • (2013) Mol Immunol , vol.56 , pp. 28-37
    • Xia, Y.1    Janda, A.2    Eryilmaz, E.3    Casadevall, A.4    Putterman, C.5
  • 45
    • 0032988597 scopus 로고    scopus 로고
    • Preparation and characterization of beta 1-bungarotoxin bispecific monoclonal antibody
    • PMID: 10410250
    • Yang CC, Chan HL. Preparation and characterization of beta 1-bungarotoxin bispecific monoclonal antibody. Biochem Mol Biol Int. 1999; 47: 1039-1048. PMID: 10410250.
    • (1999) Biochem Mol Biol Int , vol.47 , pp. 1039-1048
    • Yang, C.C.1    Chan, H.L.2
  • 46
    • 0034988033 scopus 로고    scopus 로고
    • The comparison of the ability of monoclonal antibodies directed to different proteins (human IgG, human myoglobin and HRP) and bispecific antibodies derived thereof to bind antigens immobilized on a surface of a solid phase
    • PMID: 11408007
    • Dmitriev DA, Massino YS, Segal OL, Smirnova MB, Kolyaskina GI, Pavlova EV, et al. The comparison of the ability of monoclonal antibodies directed to different proteins (human IgG, human myoglobin and HRP) and bispecific antibodies derived thereof to bind antigens immobilized on a surface of a solid phase. Clin Chim Acta. 2001; 309: 57-71. PMID: 11408007.
    • (2001) Clin Chim Acta , vol.309 , pp. 57-71
    • Dmitriev, D.A.1    Massino, Y.S.2    Segal, O.L.3    Smirnova, M.B.4    Kolyaskina, G.I.5    Pavlova, E.V.6
  • 47
    • 84891629657 scopus 로고    scopus 로고
    • Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies
    • PMID: 23872324
    • Harms BD, Kearns JD, Iadevaia S, Lugovskoy AA. Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies. Methods. 2014; 65: 95- 104. doi:10.1016/j.ymeth.2013.07.017 PMID: 23872324.
    • (2014) Methods , vol.65 , pp. 95-104
    • Harms, B.D.1    Kearns, J.D.2    Iadevaia, S.3    Lugovskoy, A.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.