Effectiveness and Clinical Outcomes of a Two-Step Implementation of Conservative Oxygenation Targets in Critically Ill Patients: A before and after Trial

Critical Care Medicine

Volumn 44, Issue 3, 2016, Pages 554-563

  Helmerhorst, Hendrik J F ^a,b   Schultz, Marcus J ^b   Van Der Voort, Peter H J ^c,d   Bosman, Robert J ^c   Juffermans, Nicole P ^b   De Wilde, Rob B P ^a   Van Den Akker Van Marle, M Elske ^e   Van Bodegom Vos, Leti ^e   De Vries, Marieke ^d   Eslami, Saeid ^b,f   De Keizer, Nicolette F ^b   Abu Hanna, Ameen ^b   Van Westerloo, David J ^a   De Jonge, Evert ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

^d TILBURG UNIVERSITY   (Netherlands)

^e LEIDEN UNIVERSITY   (Netherlands)

^f MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Clinical outcomes; computerized decision support system; conservative oxygen therapy; hyperoxia; implementation; intensive care unit; mechanical ventilation; oxygenation

Indexed keywords

OXYHEMOGLOBIN; OXYGEN;

ADULT; AGED; APACHE; ARTERIAL GAS; ARTERIAL OXYGEN SATURATION; ARTERIAL OXYGEN TENSION; ARTICLE; ARTIFICIAL VENTILATION; BODY MASS; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CONSERVATIVE TREATMENT; CRITICALLY ILL PATIENT; DECISION SUPPORT SYSTEM; DISEASE SEVERITY; FEMALE; HUMAN; HYPEROXIA; HYPOXIA; INTENSIVE CARE; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; OUTCOME ASSESSMENT; OXYGEN THERAPY; POSITIVE END EXPIRATORY PRESSURE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PULSE OXIMETRY; SIMPLIFIED ACUTE PHYSIOLOGY SCORE; TISSUE OXYGENATION; VENTILATED PATIENT; ADVERSE EFFECTS; ANOXIA; BLOOD; BLOOD GAS ANALYSIS; BREATHING; CLINICAL DECISION SUPPORT SYSTEM; CRITICAL ILLNESS; ETIOLOGY; HOSPITAL MORTALITY; NETHERLANDS; PREVENTION AND CONTROL; PROCEDURES; STANDARDS; TREATMENT OUTCOME;

AGED; ANOXIA; BLOOD GAS ANALYSIS; CRITICAL ILLNESS; DECISION SUPPORT SYSTEMS, CLINICAL; FEMALE; GUIDELINE ADHERENCE; HOSPITAL MORTALITY; HUMANS; HYPEROXIA; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; NETHERLANDS; OXYGEN; OXYGEN INHALATION THERAPY; PRACTICE GUIDELINES AS TOPIC; RESPIRATION; RESPIRATION, ARTIFICIAL; TREATMENT OUTCOME;

EID: 84959191558     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001461     Document Type: Article

References (37)

1. Altemeier WA, Sinclair SE: Hyperoxia in the intensive care unit: Why more is not always better. Curr Opin Crit Care 2007; 13:73-78
2. Farquhar H, Weatherall M, Wijesinghe M, et al: Systematic review of studies of the effect of hyperoxia on coronary blood flow. Am Heart J 2009; 158:371-377
3. Gore A, Muralidhar M, Espey MG, et al: Hyperoxia sensing: From molecular mechanisms to significance in disease. J Immunotoxicol 2010; 7:239-254
4. Asfar P, Singer M, Radermacher P. Understanding the benefits and harms of oxygen therapy. Intensive Care Med 2015; 41:1118-1121
5. Damiani E, Adrario E, Girardis M, et al: Arterial hyperoxia and mortality in critically ill patients: A systematic review and meta-analysis. Crit Care 2014; 18:711
6. Wang CH, Chang WT, Huang CH, et al: The effect of hyperoxia on survival following adult cardiac arrest: A systematic review and meta-analysis of observational studies. Resuscitation 2014; 85: 1142-1148
7. Kilgannon JH, Jones AE, Shapiro NI, et al; Emergency Medicine Shock Research Network (EMShockNet) Investigators: Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 2010; 303:2165-2171
8. Meyhoff CS, Jorgensen LN, Wetterslev J, et al; PROXI Trial Group: Risk of new or recurrent cancer after a high perioperative inspiratory oxygen fraction during abdominal surgery. Br J Anaesth 2014; 113(Suppl 1):i74-i81
9. Sjöberg F, Singer M: The medical use of oxygen: A time for critical reappraisal. J Intern Med 2013; 274:505-528
10. Helmerhorst HJ, Roos-Blom MJ, van Westerloo DJ, et al: Association between arterial hyperoxia and outcome in subsets of critical illness: A systematic review, meta-analysis, and meta-regression of cohort studies. Crit Care Med 2015; 43:1508-1519
11. Helmerhorst HJ, Schultz MJ, van der Voort PH, et al: Self-reported attitudes versus actual practice of oxygen therapy by ICU physicians and nurses. Ann Intensive Care 2014; 4:23
12. Suzuki S, Eastwood GM, Peck L, et al: Current oxygen management in mechanically ventilated patients: A prospective observational cohort study. J Crit Care 2013; 28:647-654
13. Suzuki S, Eastwood GM, Glassford NJ, et al: Conservative oxygen therapy in mechanically ventilated patients: A pilot before-and-after trial. Crit Care Med 2014; 42:1414-1422
14. Mikkelsen ME, Anderson B, Christie JD, et al: Can we optimize longterm outcomes in acute respiratory distress syndrome by targeting normoxemia Ann Am Thorac Soc 2014; 11:613-618
15. Martin DS, Grocott MP: Oxygen therapy in critical illness: Precise control of arterial oxygenation and permissive hypoxemia. Crit Care Med 2013; 41:423-432
16. Gilbert-Kawai ET, Mitchell K, Martin D, et al: Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients. Cochrane Database Syst Rev 2014; 5:CD009931
17. Arts D, de Keizer N, Scheffer GJ, et al: Quality of data collected for severity of illness scores in the Dutch National Intensive Care Evaluation (NICE) registry. Intensive Care Med 2002; 28:656-659
18. Brower RG, Lanken PN, MacIntyre N, et al; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network: Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004; 351:327-336
19. Patroniti N, Iotti GA. Mechanical Ventilation-skills and techniques. Patient-centered Acute Care Training (PACT) Module-European Society of Intensive Care Medicine 2011. Available at: http://pact. esicm.org/media/Mechanical%20vent%201Feb2011%20final.pdf. Accessed June 1, 2015
20. Goud R, de Keizer NF, ter Riet G, et al: Effect of guideline based computerised decision support on decision making of multidisciplinary teams: Cluster randomised trial in cardiac rehabilitation. BMJ 2009; 338:b1440
21. Randolph AG, Haynes RB, Wyatt JC, et al: Users' guides to the medical literature: XVIII. How to use an article evaluating the clinical impact of a computer-based clinical decision support system. JAMA 1999; 282:67-74
22. de Jonge E, Peelen L, Keijzers PJ, et al: Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Crit Care 2008; 12:R156
23. Eastwood G, Bellomo R, Bailey M, et al: Arterial oxygen tension and mortality in mechanically ventilated patients. Intensive Care Med 2012; 38:91-98
24. Schoenfeld DA, Bernard GR; ARDS Network: Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome. Crit Care Med 2002; 30:1772-1777
25. de Graaff AE, Dongelmans DA, Binnekade JM, et al: Clinicians' response to hyperoxia in ventilated patients in a Dutch ICU depends on the level of FiO2. Intensive Care Med 2011; 37:46-51
26. Greenland S: Modeling and variable selection in epidemiologic analysis. Am J Public Health 1989; 79:340-349
27. Rubenfeld GD: Translating clinical research into clinical practice in the intensive care unit: The central role of respiratory care. Respir Care 2004; 49:837-843
28. Cahill NE, Suurdt J, Ouellette-Kuntz H, et al: Understanding adherence to guidelines in the intensive care unit: Development of a comprehensive framework. JPEN J Parenter Enteral Nutr 2010; 34:616-624
29. Jones NE, Suurdt J, Ouelette-Kuntz H, et al: Implementation of the Canadian clinical practice guidelines for nutrition support: A multiple case study of barriers and enablers. Nutr Clin Pract 2007; 22:449-457
30. Simpson F, Doig GS: The relative effectiveness of practice change interventions in overcoming common barriers to change: A survey of 14 hospitals with experience implementing evidence-based guidelines. J Eval Clin Pract 2007; 13:709-715
31. Prior M, Guerin M, Grimmer-Somers K: The effectiveness of clinical guideline implementation strategies-A synthesis of systematic review findings. J Eval Clin Pract 2008; 14:888-897
32. Hunt DL, Haynes RB, Hanna SE, et al: Effects of computer-based clinical decision support systems on physician performance and patient outcomes: A systematic review. JAMA 1998; 280:1339-1346
33. Eslami S, Abu-Hanna A, de Jonge E, et al: Tight glycemic control and computerized decision-support systems: A systematic review. Intensive Care Med 2009; 35:1505-1517
34. Eslami S, de Keizer NF, Dongelmans DA, et al: Effects of two different levels of computerized decision support on blood glucose regulation in critically ill patients. Int J Med Inform 2012; 81: 53-60
35. Eslami S, Abu-Hanna A, Schultz MJ, et al. Evaluation of consulting and critiquing decision support systems: Effect on adherence to a lower tidal volume mechanical ventilation strategy. J Crit Care 2012; 27:425.e1-425.e8
36. Meyhoff CS, Jorgensen LN, Wetterslev J, et al; PROXI Trial Group: Increased long-term mortality after a high perioperative inspiratory oxygen fraction during abdominal surgery: Follow-up of a randomized clinical trial. Anesth Analg 2012; 115:849-854
37. Eastwood GM, Peck L, Young H, et al: Intensive care clinicians' opinion of conservative oxygen therapy (SpO2 90-92%) for mechanically ventilated patients. Aust Crit Care 2014; 27:120-125