The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits

PLoS Neglected Tropical Diseases

Volumn 9, Issue 10, 2015, Pages

  Crisford, Anna ^a   Ebbinghaus Kintscher, Ulrich ^b   Schoenhense, Eva ^b,e   Harder, Achim ^c,f   Raming, Klaus ^b   O’Kelly, Ita ^d   Ndukwe, Kelechi ^a,g   O’Connor, Vincent ^a   Walker, Robert J ^a   Holden Dye, Lindy ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b BAYER CROPSCIENCE AG   (Germany)

^c BAYER AG   (Germany)

^d SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^e UNIVERSITY OF BONN   (Germany)

^f HEINRICH HEINE UNIVERSITY   (Germany)

^g CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA; DIMETHYL SULFOXIDE; EMODEPSIDE; ENHANCED GREEN FLUORESCENT PROTEIN; MYCOTOXIN; PENITREM A; UNCLASSIFIED DRUG; VERRUCULOGEN; ANTHELMINTIC AGENT; CALCIUM; DEPSIPEPTIDE; KCNMA1 PROTEIN, HUMAN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; PROTEIN SUBUNIT;

ANIMAL CELL; ANTHELMINTIC ACTIVITY; ARTICLE; BEHAVIOR ASSESSMENT; CAENORHABDITIS ELEGANS; CHO CELL LINE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; DROSOPHILA SLO; FLUORESCENCE ANALYSIS; GENE AMPLIFICATION; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IC50; MEMBRANE POTENTIAL; NEMATODIASIS; NONHUMAN; POTASSIUM CURRENT; PROTEIN EXPRESSION; VOLTAGE CLAMP TECHNIQUE; ANIMAL; ANTAGONISTS AND INHIBITORS; CRICETULUS; DRUG EFFECTS; METABOLISM; PROTEIN SUBUNIT;

ANIMALS; ANTHELMINTICS; CALCIUM; CHO CELLS; CRICETULUS; DEPSIPEPTIDES; DROSOPHILA MELANOGASTER; HEK293 CELLS; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; PROTEIN SUBUNITS;

EID: 84959177356     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0004062     Document Type: Article

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