Effects of maternal age on euploidy rates in a large cohort of embryos analyzed with 24-chromosome single-nucleotide polymorphism-based preimplantation genetic screening

Fertility and Sterility

Volumn 105, Issue 5, 2016, Pages 1307-1313

  Demko, Zachary P ^a   Simon, Alexander L ^a   McCoy, Rajiv C ^b   Petrov, Dmitri A ^c   Rabinowitz, Matthew ^a  

^a NATERA INC   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Aneuploidy; fertility; in vitro fertilization; maternal age; preimplantation genetic screening

Indexed keywords

ADULT; ANEUPLOIDY; ARTICLE; CHROMOSOME; CHROMOSOMES AND CHROMOSOMAL PHENOMENA; COHORT ANALYSIS; EMBRYO; EUPLOIDY; FEMALE; FERTILIZATION IN VITRO; GENETIC SCREENING; HUMAN; MATERNAL AGE; OOCYTE RETRIEVAL; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; EMBRYO DEVELOPMENT; GENETICS; PREGNANCY; PREIMPLANTATION GENETIC DIAGNOSIS; PROCEDURES; TRENDS;

ADULT; ANEUPLOIDY; COHORT STUDIES; EMBRYONIC DEVELOPMENT; FEMALE; HUMANS; MATERNAL AGE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PREIMPLANTATION DIAGNOSIS; RETROSPECTIVE STUDIES;

EID: 84959117447     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2016.01.025     Document Type: Article

References (37)

1. N.R. Treff Genome-wide analysis of human preimplantation aneuploidy Semin Reprod Med 30 2012 283 288
2. T. Hassold, and P. Hunt To err (meiotically) is human: the genesis of human aneuploidy Nat Rev Genet 2 2001 280 291
3. T. Hassold, M. Abruzzo, K. Adkins, D. Griffin, M. Merrill, E. Millie, and et al. Human aneuploidy: incidence, origin, and etiology Environ Mol Mutagen 28 1996 167 175
4. R.B. Lathi, S.L. Gustin, J. Keller, M.K. Maisenbacher, S. Sigurjonsson, R. Tao, and et al. Reliability of 46,XX results on miscarriage specimens: a review of 1,222 first trimester miscarriage specimens Fertil Steril 101 2014 178 182
5. R.B. Lathi, J.A. Massie, M. Loring, Z.P. Demko, D. Johnson, S. Sigurjonsson, and et al. Informatics enhanced SNP microarray analysis of 30 miscarriage samples compared to routine cytogenetics PLoS One 7 2012 e31282
6. B. Hodes-Wertz, J. Grifo, S. Ghadir, B. Kaplan, C.A. Laskin, M. Glassner, and et al. Idiopathic recurrent miscarriage is caused mostly by aneuploid embryos Fertil Steril 98 2012 675 680
7. S.I. Nagaoka, T.J. Hassold, and P.A. Hunt Human aneuploidy: mechanisms and new insights into an age-old problem Nat Rev Genet 13 2013 493 504
8. T. Hassold, H. Hall, and P. Hunt The origin of human aneuploidy: where we have been, where we are going Hum Mol Genet 16 2007 R203 R208
9. T. Chiang, R.M. Schultz, and M.A. Lampson Meiotic origins of maternal age-related aneuploidy Biol Reprod 86 2012 1 7
10. H.J. Stern Preimplantation genetic diagnosis: prenatal testing for embryos finally achieving its potential J Clin Med 3 2014 280 309
11. M. Rabinowitz, A. Ryan, G. Gemelos, M. Hill, J. Baner, C. Cinnioglu, and et al. Origins and rates of aneuploidy in human blastomeres Fertil Steril 97 2012 395 401
12. G.L. Harton, S. Munne, M. Surrey, J. Grifo, B. Kaplan, D.H. McCulloh, and et al. Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization Fertil Steril 100 2013 1695 1703
13. N.R. Treff, and R.T. Scott Methods for comprehensive chromosome screening of oocytes and embryos: capabilities, limitations, and evidence of validity J Assist Reprod Genet 29 2012 381 390
14. S.T. Qi, L.F. Liang, Y.X. Xian, J.Q. Liu, and W. Wang Arrested human embryos are more likely to have abnormal chromosomes than developing embryos from women of advanced maternal age J Ovarian Res 7 2014 65
15. T. Hardarson, C. Hanson, K. Lundin, T. Hillensjo, L. Nilsson, J. Stevic, and et al. Preimplantation genetic screening in women of advanced maternal age caused a decrease in clinical pregnancy rate: a randomized controlled trial Hum Reprod 23 2008 2806 2812
16. S. Mastenbroek, M. Twisk, J. van Echten-Arends, B. Sikkema-Raddatz, J.C. Korevaar, H.R. Verhoeve, and et al. In vitro fertilization with preimplantation genetic screening N Engl J Med 357 2007 9 17
17. R.T. Scott, K.M. Upham, E.J. Forman, K.H. Hong, K.L. Scott, X. Tao, and et al. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial Fertil Steril 100 2013 697 703
18. E.J. Forman, K.H. Hong, J.M. Franasiak, and R.T.J. Scott Obstetrical and neonatal outcomes from the BEST trial: single embryo transfer with aneuploidy screening improves outcomes after in vitro fertilization without compromising delivery rates Am J Obstet Gynecol 210 2014 157.e1 157.e6
19. R.T. Scott, K. Ferry, J. Su, X. Tao, K. Scott, and N.R. Treff Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study Fertil Steril 97 2012 870 875
20. W.B. Schoolcraft, N.R. Treff, J.M. Stevens, K. Ferry, M. Katz-Jaffe, and R.T. Scott Jr. Live birth outcome with trophectoderm biopsy, blastocyst vitrification, and single-nucleotide polymorphism microarray-based comprehensive chromosome screening in infertile patients Fertil Steril 96 2011 638 640
21. D. Wells, and J.D. Delhanty Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization Mol Hum Reprod 6 2000 1055 1062
22. D.S. Johnson, G. Gemelos, J. Baner, A. Ryan, C. Cinnioglu, M. Banjevic, and et al. Preclinical validation of a microarray method for full molecular karyotyping of blastomeres in a 24-h protocol Hum Reprod 25 2010 1066 1075
23. M. Kuwayama Highly efficient vitrification for cryopreservation of human oocytes and embryos: the Cryotop method Theriogenology 67 2007 73 80
24. E. Fragouli, M. Lenzi, R. Ross, M. Katz-Jaffe, W.B. Schoolcraft, and D. Wells Comprehensive molecular cytogenetic analysis of the human blastocyst stage Hum Reprod 23 2008 2596 2608
25. S. Alfarawati, E. Fragouli, P. Colls, J. Stevens, C. Gutierrez-Mateo, W.B. Schoolcraft, and et al. The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender Fertil Steril 95 2011 520 524
26. R.C. McCoy, Z. Demko, A. Ryan, M. Banjevic, M. Hill, S. Sigurjonsson, and et al. Evidence of selection against complex mitotic-origin aneuploidy during preimplantation development PLoS Genet 11 2015 e1005601
27. C. Samango-Sprouse, M. Banjevic, A. Ryan, S. Sigurjonsson, B. Zimmermann, M. Hill, and et al. SNP-based non-invasive prenatal testing detects sex chromosome aneuploidies with high accuracy Prenat Diagn 33 2013 643 649
28. W. Weibull A statistical distribution function of wide applicability J Appl Mech 18 1951 293 297
29. R.E. Ricklefs, and A. Scheuerlein Biological implications of the Weibull and Gompertz models of aging J Gerontol A Biol Sci Med Sci 57 2002 B69 B76
30. J.M. Franasiak, E.J. Forman, K.H. Hong, M.D. Werner, K.M. Upham, N.R. Treff, and et al. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening Fertil Steril 101 2014 656 663
31. E.S. Sills, X. Li, J.L. Frederick, C.D. Khoury, and D.A. Potter Determining parental origin of embryo aneuploidy: analysis of genetic error observed in 305 embryos derived from anonymous donor oocyte IVF cycles Mol Cytogenet 7 2014 68
32. B. Ata, B. Kaplan, H. Danzer, M. Glassner, M. Opsahl, S.L. Tan, and et al. Array CGH analysis shows that aneuploidy is not related to the number of embryos generated Reprod Biomed Online 24 2012 614 620
33. J. Liu, W. Wang, X. Sun, L. Liu, H. Jin, M. Li, and et al. DNA microarray reveals that high proportions of human blastocysts from women of advanced maternal age are aneuploid and mosaic Biol Reprod 87 2012 148
34. A. Adler, H.L. Lee, D.H. McCulloh, E. Ampeloquio, M. Clarke-Williams, B. Hodes-Wertz, and et al. Blastocyst culture selects for euploid embryos: comparison of blastomere and trophectoderm biopsies Reprod Biomed Online 28 2014 485 491
35. D. Glujovsky, D. Blake, C. Farquhar, and A. Bardach Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology Cochrane Database Syst Rev 2012 CD002118
36. D.A. Blake, C.M. Farquhar, N. Johnson, and M. Proctor Cleavage stage versus blastocyst stage embryo transfer in assisted conception Cochrane Database Syst Rev 2007 CD002118
37. E. Greco, M.G. Minasi, and F. Florentino Healthy babies after intrauterine transfer of mosaic aneuploid blastocysts N Engl J Med 373 2015 2089 2090