In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery

International Journal of Pharmaceutics

Volumn 502, Issue 1-2, 2016, Pages 70-79

  Al Khateb, Kosai ^a   Ozhmukhametova, Elvira K ^b   Mussin, Marat N ^b   Seilkhanov, Serzhan K ^b   Rakhypbekov, Tolebai K ^b   Lau, Wing Man ^a   Khutoryanskiy, Vitaliy V ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b SEMEY MEDICAL UNIVERSITY   (Kazakhstan)

Author keywords

Gelation; In situ gelling systems; Mucoadhesion; Ocular drug delivery; Pluronics

Indexed keywords

BENZALKONIUM CHLORIDE; FLUORESCEIN SODIUM; GLASS; OFLOXACIN; POLOXAMER; POLYMER; EXCIPIENT; GEL; MICELLE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BIOASSAY; BIOCOMPATIBILITY; BOVINE; CONTROLLED STUDY; CORNEA; CORNEA EROSION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RETENTION; DRUG STABILITY; FLOW KINETICS; GEL; GELATION; IN VITRO STUDY; IN VIVO STUDY; MICELLIZATION; MOLECULAR WEIGHT; MUCOSA IRRITATION ASSAY; NONHUMAN; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; RABBIT; SURFACE PROPERTY; TEMPERATURE; ANIMAL; CHEMISTRY; DRUG EFFECTS; EYE; GASTROPOD; INTRAOCULAR DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; METABOLISM; MICELLE; MUCOSA; MUCUS; RABBITS AND HARES;

ADMINISTRATION, OPHTHALMIC; ANIMALS; CATTLE; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; EXCIPIENTS; EYE; GASTROPODA; GELS; MICELLES; MUCOUS MEMBRANE; MUCUS; POLOXAMER; RABBITS; RHEOLOGY;

EID: 84959098680     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.02.027     Document Type: Article

References (37)

1. E. Adriaens, and J.P. Remon Gastropods as an evaluation tool for screening the irritating potency of absorption enhancers and drugs Pharm. Res. 16 8 1999 1240 1244
2. E. Adriaens, M.M. Dhondt, and J.P. Remon Refinement of the Slug Mucosal Irritation test as an alternative screening test for eye irritation Toxicol. In Vitro 19 1 2005 79 89
3. A.K. Agrawal, M. Das, and S. Jain In situ gel systems as 'smart' carriers for sustained ocular drug delivery Expert Opin. Drug Deliv. 9 2012 383 402
4. M.S. Akash, and K. Rehman Recent progress in biomedical applications of Pluronic (PF127): Pharmaceutical perspectives J. Control. Release. 209 2015 120 138
5. V. Aseyev, H. Tenhu, and F.M. Winnik Non-ionic thermoresponsive polymers in water Adv. Polym. Sci. 242 2011 29 89
6. E.V. Batrakova, and A.V. Kabanov Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers J. Control. Release 130 2 2008 98 106
7. A.E. Beezer, W. Loh, J.C. Mitchell, P.G. Royall, D.O. Smith, M.S. Tute, J.K. Armstrong, B.Z. Chowdhry, S.A. Leharne, D. Eagland, and N.J. Crowther An investigation of dilute aqueous solutions behaviour of Poly(oxyethylene) + Poly(oxypropylene) + Poly(oxyethylene) block copolymers Langmuir 10 1994 4001 4005
8. R.A. Cave, J.P. Cook, C.J. Connon, and V.V. Khutoryanskiy A flow system for the on-line quantitative measurement of the retention of dosage forms on biological surfaces using spectroscopy and image analysis Int J. Pharm. 428 2012 96 102
9. K.Y. Cho, T.W. Chung, B.C. Kim, M.K. Kim, J.H. Lee, W.R. Wee, and C.S. Cho Release of ciprofloxacin from poloxamer-graft-hyaluronic acid hydrogels in vitro Int. J. Pharm. 260 1 2003 83 91
10. Y.-I. Chung, S.-Y. Lee, and G. Tae The effect of heparin on the gelation of Pluronic F-127 hydrogel Colloids Surf. A 284-285 2006 480 484
11. M.T. Cook, S.L. Smith, and V.V. Khutoryanskiy Novel glycopolymer hydrogels as mucosa-mimetic materials to reduce animal testing Chem. Commun. 51 2015 14447 14450
12. K. Edsman, J. Carlfors, and R. Petersson Rheological evaluation of poloxamer as an in situ gel for ophthalmic use Eur. J. Pharm. Sci. 6 1998 105 112
13. A.H. El-Kamel In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate Int. J. Pharm. 241 2002 47 55
14. P.M. Hughes, O. Olejnik, J.-E. Chang-Lin, and C.G. Wilson Topical and systemic drug delivery to the posterior segments Adv. Drug Deliv. Rev. 57 2005 2010 2032
15. el.-S.A. Ibrahim, S. Ismail, G. Fetih, O. Shaaban, K. Hassanein, and N.H. Abdellah Development and characterization of thermosensitive pluronic-based metronidazole in situ gelling formulations for vaginal application Acta Pharm. 62 2012 59 70
16. G.S. Irmukhametova, G.A. Mun, and V.V. Khutoryanskiy Thiolated mucoadhesive and PEGylated non-mucoadhesive organosilica nanoparticles from 3-mercaptopropyl-trimethoxysilane Langmuir 27 2011 9551 9556
17. K. Järvinen, T. Järvinen, and A. Urtti Ocular absorption following topical delivery Adv. Drug Deliv. Rev. 16 1995 3 19
18. ® micelles: effect of molecular characteristics, temperature and added salt on the solubilizing capacity Colloids Surf. B 72 2009 141 147
19. O.V. Khutoryanskaya, Z.A. Mayeva, G.A. Mun, and V.V. Khutoryanskiy Designing temperature-responsive biocompatible copolymers and hydrogels based on 2-hydroxyethyl(meth) acrylates Biomacromolecules 9 2008 3353 3361
20. O.V. Khutoryanskaya, P.W.J. Morrison, S.K. Seilkhanov, M.N. Mussin, E.K. Ozhmukhametova, T.K. Rakhypbekov, and V.V. Khutoryanskiy Hydrogen-bonded complexes and blends of poly(acrylic acid) and methylcellulose: nanoparticles and mucoadhesive films for ocular delivery of riboflavin Macromol. Biosci. 14 2014 225 234
21. H.R. Lin, K.C. Sung, and W.J. Vong In situ gelling of alginate/pluronic solutions for ophthalmic delivery of pilocarpine Biomacromolecules 5 2004 2358 2365
22. A. Ludwig The use of mucoadhesive polymers in ocular drug delivery Adv. Drug Deliv. Rev. 57 2005 1595 1639
23. P.W.J. Morrison, and V.V. Khutoryanskiy Advances in ophthalmic drug delivery Ther. Deliv. 5 12 2014 1307 1325
24. P.W.J. Morrison, C.J. Connon, and V.V. Khutoryanskiy Cyclodextrin-mediated enhancement of riboflavin solubility and corneal permeability Mol. Pharm. 10 2 2013 756 762
25. E.A. Mun, P.W.J. Morrison, A.C. Williams, and V.V. Khutoryanskiy On the barrier properties of the cornea: a microscopy study of the penetration of fluorescently labeled nanoparticles, polymers, and sodium fluorescein Mol. Pharm. 11 10 2014 3556 3564
26. Z.S. Nurkeeva, G.A. Mun, V.V. Khutoryanskiy, A.B. Bitekenova, and A.B. Dzhusupbekova Polymeric complexes of poly(acrylic acid) and poly(2-hydroxyethyl vinyl ether) with lidocaine hydrochloride J. Biomat. Sci. Polym. Edn. 13 2002 759 768
27. Z.S. Nurkeeva, V.V. Khutoryanskiy, G.A. Mun, M.V. Sherbakova, A.T. Ivaschenko, and N.A. Aitkhozhina Polycomplexes of poly(acrylic acid) with streptomycin sulfate and their antibacterial activity Eur. J. Pharm. Biopharm. 57 2 2004 245 249
28. K.T. Oh, T.K. Bronich, and A.V. Kabanov Micellar formulations for drug delivery based on mixtures of hydrophobic and hydrophilic Pluronic block copolymers J. Controlled Release 94 1 2004 411 422
29. ® F127-polyethylene glycol mixtures: relationship to PEG molecular weight Drug Devel. Ind. Pharm. 24 1998 183 186
30. L.C. Pham Trong, M. Djabourov, and A. Ponton Mechanisms of micellization and rheology of PEO-PPO-PEO triblock copolymers with various architectures J. Colloid Interface Sci. 328 2 2008 278 287
31. L. Sek, B.J. Boyd, W.N. Charman, and C.J. Porter Examination of the impact of a range of Pluronic surfactants on the in-vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone J. Pharm. Pharmacol. 58 6 2006 809 820
32. ® F127: micellar assembly, gelation and partitioning Int. J Pharm. 278 2 2004 361 377
33. T.R. Thrimawithana, I.D. Rupenthal, S.A. Young, and R.G. Alany Environment-sensitive polymers for ophthalmic drug delivery J. Drug Deliv. Sci. Technol. 22 2012 117 124
34. J. Varshosaz, M. Tabbakhian, and Z. Salmani Designing of a thermosensitive Chitosan/poloxamer in situ gel for ocular delivery of ciprofloxacin Open Drug Deliv. J. 2 2008 61 70
35. G. Wei, H. Xu, P.T. Ding, S.M. Li, and J.M. Zheng Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies J. Controlled Release 83 1 2002 65 74
36. C.A. Withers, M.T. Cook, L. Methven, M.A. Gosney, and V.V. Khutoryanskiy Investigation of milk proteins binding to the oral mucosa Food Funct. 4 2013 1668 1674
37. ® mixtures Int. J. Pharm. 454 2013 599 610