메뉴 건너뛰기




Volumn 10, Issue 3, 2016, Pages 359-370

Optimizing the diagnosis and the treatment of iron overload diseases

Author keywords

Ferritin; Ferroportin; Hemochromatosis; Hemojuvelin; Hepcidin; Iron chelation; Iron overload; Non transferrin bound iron; Transferrin saturation; Venesection

Indexed keywords

DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; DEFEROXAMINE MESYLATE; FERRITIN; FERROPORTIN; HEPCIDIN; HFE PROTEIN; IRON; REACTIVE OXYGEN METABOLITE; TRANSFERRIN; BIOLOGICAL MARKER; IRON CHELATING AGENT;

EID: 84959075144     PISSN: 17474124     EISSN: 17474132     Source Type: Journal    
DOI: 10.1586/17474124.2016.1119043     Document Type: Review
Times cited : (37)

References (66)
  • 1
    • 84954306618 scopus 로고    scopus 로고
    • Iron metabolism and related genetic diseases: A cleared land, keeping mysteries
    • Nov 170. [Epub ahead of print] Review
    • Brissot P, Loréal O. Iron metabolism and related genetic diseases: A cleared land, keeping mysteries. J Hepatol. 2015 Nov 17. pii: S0168-8278(15)00742-4. doi: 10.1016/j.jhep.2015.11.009. [Epub ahead of print] Review
    • (2015) J Hepatol
    • Brissot, P.1    Loréal, O.2
  • 2
    • 82955164167 scopus 로고    scopus 로고
    • Iron disorders of genetic origin: A changing world
    • Brissot P, Bardou-Jacquet E, Jouanolle AM, et al. Iron disorders of genetic origin: a changing world. Trends Mol Med. 2011; 17 (12): 707-713
    • (2011) Trends Mol Med , vol.17 , Issue.12 , pp. 707-713
    • Brissot, P.1    Bardou-Jacquet, E.2    Jouanolle, A.M.3
  • 3
    • 84887850175 scopus 로고    scopus 로고
    • Diagnosis and treatment of hereditary hemochromatosis: An update
    • Kanwar P, Kowdley KV. Diagnosis and treatment of hereditary hemochromatosis: an update. Expert Rev Gastroenterol Hepatol. 2013; 7 (6): 517-530
    • (2013) Expert Rev Gastroenterol Hepatol , vol.7 , Issue.6 , pp. 517-530
    • Kanwar, P.1    Kowdley, K.V.2
  • 4
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    • Feder JN, Gnirke A, Thomas W, et al A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996; 13 (4): 399-408
    • (1996) Nat Genet , vol.13 , Issue.4 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3
  • 5
    • 38349079861 scopus 로고    scopus 로고
    • Iron-overload-related disease in HFE hereditary hemochromatosis
    • Allen KJ, Gurrin LC, Constantine CC, et al. Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med. 2008; 358 (3): 221-230
    • (2008) N Engl J Med , vol.358 , Issue.3 , pp. 221-230
    • Allen, K.J.1    Gurrin, L.C.2    Constantine, C.C.3
  • 6
    • 84882737406 scopus 로고    scopus 로고
    • Increased height in HFE hemochromatosis
    • Cippa PE, Krayenbuehl PA. Increased height in HFE hemochromatosis. N Engl J Med. 2013; 369 (8): 785-786
    • (2013) N Engl J Med , vol.369 , Issue.8 , pp. 785-786
    • Cippa, P.E.1    Krayenbuehl, P.A.2
  • 7
    • 84944191535 scopus 로고    scopus 로고
    • Eighty percent of French sport winners in Olympic, World and Europeans competitions have mutations in the hemochromatosis HFE gene
    • Sep 28. [Epub ahead of print]
    • Hermine O, Dine G, Genty V, et al. Eighty percent of French sport winners in Olympic, World and Europeans competitions have mutations in the hemochromatosis HFE gene. Biochimie. 2015 Sep 28. pii: S0300-9084(15)00303-X. doi: 10.1016/j.biochi.2015.09.028. [Epub ahead of print]
    • (2015) Biochimie
    • Hermine, O.1    Dine, G.2    Genty, V.3
  • 9
    • 84975081908 scopus 로고    scopus 로고
    • The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data
    • Dec 3. [Epub ahead of print]
    • Wallace DF, Subramaniam N. The global prevalence of HFE and non-HFE hemochromatosis estimated from analysis of next-generation sequencing data. Genet Med. 2015 Dec 3. doi: 10.1038/gim.2015.140. [Epub ahead of print]
    • (2015) Genet Med
    • Wallace, D.F.1    Subramaniam, N.2
  • 10
    • 84959460043 scopus 로고    scopus 로고
    • Iron deficiency anaemia
    • aug 24. [Epub ahead of print] Review
    • Lopez A, Cacoub P, Macdougall IC, et al. Iron deficiency anaemia. Lancet. 2015 Aug 24. pii: S0140-6736(15)60865-0. doi: 10.1016/S0140-6736(15)60865-0. [Epub ahead of print] Review
    • (2015) Lancet
    • Lopez, A.1    Cacoub, P.2    Macdougall, I.C.3
  • 11
    • 84960312577 scopus 로고    scopus 로고
    • Iron therapy in chronic kidney disease: Recent changes, benefits and risks
    • aug 18. [Epub ahead of print]
    • Ribeiro S, Belo L, Reis F, et al. Iron therapy in chronic kidney disease: Recent changes, benefits and risks. Blood Rev. 2015 Aug 18. pii: S0268-960X(15)00062-4. doi: 10.1016/j.blre.2015.07.006. [Epub ahead of print]
    • (2015) Blood Rev
    • Ribeiro, S.1    Belo, L.2    Reis, F.3
  • 12
    • 84904745447 scopus 로고    scopus 로고
    • The pathophysiology of transfusional iron overload
    • Aug
    • Porter JB, Garbowski M. The pathophysiology of transfusional iron overload. Hematol Oncol Clin North Am. 2014 Aug;28(4): 683-701
    • (2014) Hematol Oncol Clin North Am , vol.28 , Issue.4 , pp. 683-701
    • Porter, J.B.1    Garbowski, M.2
  • 13
    • 84861399953 scopus 로고    scopus 로고
    • Iron overload in non-Transfusion-dependent thalassemia: A clinical perspective
    • Musallam KM, Cappellini MD, Wood JC, et al. Iron overload in non-Transfusion-dependent thalassemia: a clinical perspective. Blood Rev. 2012; 26 (Suppl 1): S16-9
    • (2012) Blood Rev , vol.26 , pp. S16-S19
    • Musallam, K.M.1    Cappellini, M.D.2    Wood, J.C.3
  • 14
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, et al A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. Biol Chem. 2001; 276 (11): 7811-7819
    • (2001) Biol Chem , vol.276 , Issue.11 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 15
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA. 2001; 98 (15): 8780-8785
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.15 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3
  • 16
    • 84885768132 scopus 로고    scopus 로고
    • Systemic iron homeostasis
    • Ganz T. Systemic iron homeostasis. Physiol Rev. 2013; 93 (4): 1721-1741
    • (2013) Physiol Rev , vol.93 , Issue.4 , pp. 1721-1741
    • Ganz, T.1
  • 17
    • 84903578007 scopus 로고    scopus 로고
    • Identification of erythroferrone as an erythroid regulator of iron metabolism
    • Kautz L, Jung G, Valore EV, et al. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014; 46 (7): 678-684
    • (2014) Nat Genet , vol.46 , Issue.7 , pp. 678-684
    • Kautz, L.1    Jung, G.2    Valore, E.V.3
  • 18
    • 84908144096 scopus 로고    scopus 로고
    • Erythroferrone contributes to recovery from anemia of inflammation
    • Kautz L, Jung G, Nemeth E, et al. Erythroferrone contributes to recovery from anemia of inflammation. Blood. 2014; 124 (16): 2569-2574
    • (2014) Blood , vol.124 , Issue.16 , pp. 2569-2574
    • Kautz, L.1    Jung, G.2    Nemeth, E.3
  • 19
    • 0018164919 scopus 로고
    • Non-specific serum iron in thalassaemia: An abnormal serum iron fraction of potential toxicity
    • Hershko C, Graham G, Bates GW, et al. Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity. Br J Haematol. 1978; 40 (2): 255-263
    • (1978) Br J Haematol , vol.40 , Issue.2 , pp. 255-263
    • Hershko, C.1    Graham, G.2    Bates, G.W.3
  • 20
    • 84857373097 scopus 로고    scopus 로고
    • Non-Transferrin bound iron: A key role in iron overload and iron toxicity
    • Brissot P, Ropert M, Le Lan C, et al. Non-Transferrin bound iron: a key role in iron overload and iron toxicity. Biochim Biophys Acta. 2012; 1820 (3): 403-410
    • (2012) Biochim Biophys Acta , vol.1820 , Issue.3 , pp. 403-410
    • Brissot, P.1    Ropert, M.2    Le Lan, C.3
  • 21
    • 84887253073 scopus 로고    scopus 로고
    • Aceruloplasminemia: An update
    • Kono S. Aceruloplasminemia: an update. Int Rev Neurobiol. 2013; 110: 125-151
    • (2013) Int Rev Neurobiol , vol.110 , pp. 125-151
    • Kono, S.1
  • 22
    • 34250800318 scopus 로고    scopus 로고
    • Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin
    • De Domenico I, Ward DM, di Patti MC, et al. Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. Embo J. 2007; 26 (12): 2823-2831
    • (2007) Embo J , vol.26 , Issue.12 , pp. 2823-2831
    • De Domenico, I.1    Ward, D.M.2    Di Patti, M.C.3
  • 23
    • 79954642381 scopus 로고    scopus 로고
    • Advances in metal-induced oxidative stress and human disease
    • Jomova K, Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology. 2011; 283 (2-3): 65-87
    • (2011) Toxicology , vol.283 , Issue.23 , pp. 65-87
    • Jomova, K.1    Valko, M.2
  • 24
    • 0141705304 scopus 로고    scopus 로고
    • Labile plasma iron in iron overload: Redox activity and susceptibility to chelation
    • Esposito BP, Breuer W, Sirankapracha P, et al. Labile plasma iron in iron overload: redox activity and susceptibility to chelation. Blood. 2003; 102 (7): 2670-2677
    • (2003) Blood , vol.102 , Issue.7 , pp. 2670-2677
    • Esposito, B.P.1    Breuer, W.2    Sirankapracha, P.3
  • 25
    • 21144441802 scopus 로고    scopus 로고
    • Redox active plasma iron in C282Y/C282Y hemochromatosis
    • Le Lan C, Loreal O, Cohen T, et al. Redox active plasma iron in C282Y/C282Y hemochromatosis. Blood. 2005; 105 (11): 4527-4531
    • (2005) Blood , vol.105 , Issue.11 , pp. 4527-4531
    • Le Lan, C.1    Loreal, O.2    Cohen, T.3
  • 27
    • 84897930584 scopus 로고    scopus 로고
    • Labile iron in cells and body fluids: Physiology, pathology, and pharmacology
    • Cabantchik ZI. Labile iron in cells and body fluids: physiology, pathology, and pharmacology. Front Pharmacol. 2014; 5: 45
    • (2014) Front Pharmacol , vol.5 , Issue.45
    • Cabantchik, Z.I.1
  • 28
    • 84892657750 scopus 로고    scopus 로고
    • The liver: Conductor of systemic iron balance
    • Jan 9
    • Meynard D, Babitt JL, Lin HY. The liver: conductor of systemic iron balance. Blood. 2014 Jan 9;123(2): 168-176
    • (2014) Blood , vol.123 , Issue.2 , pp. 168-176
    • Meynard, D.1    Babitt, J.L.2    Lin, H.Y.3
  • 29
    • 0041382554 scopus 로고    scopus 로고
    • Hemochromatosis and alcoholic liver disease
    • Fletcher LM, Powell LW. Hemochromatosis and alcoholic liver disease. Alcohol. 2003; 30 (2): 131-136
    • (2003) Alcohol , vol.30 , Issue.2 , pp. 131-136
    • Fletcher, L.M.1    Powell, L.W.2
  • 30
    • 66049158678 scopus 로고    scopus 로고
    • A new mutation in the hepcidin promoter impairs its BMP response and contributes to a severe phenotype in HFE related hemochromatosis
    • Island ML, Jouanolle AM, Mosser A, et al A new mutation in the hepcidin promoter impairs its BMP response and contributes to a severe phenotype in HFE related hemochromatosis. Haematologica. 2009; 94 (5): 720-724
    • (2009) Haematologica , vol.94 , Issue.5 , pp. 720-724
    • Island, M.L.1    Jouanolle, A.M.2    Mosser, A.3
  • 31
    • 84938209461 scopus 로고    scopus 로고
    • Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload
    • apr 23. [Epub ahead of print]
    • McLaren CE, Emond MJ, Subramaniam VN, et al. Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload. Hepatology. 2015 Apr 23. doi: 10.1002/hep.27851. [Epub ahead of print]
    • (2015) Hepatology
    • McLaren, C.E.1    Emond, M.J.2    Subramaniam, V.N.3
  • 32
    • 84869210296 scopus 로고    scopus 로고
    • Effect of the A736V TMPRSS6 polymorphism on the penetrance and clinical expression of hereditary hemochromatosis
    • Valenti L, Fracanzani AL, Rametta R, et al. Effect of the A736V TMPRSS6 polymorphism on the penetrance and clinical expression of hereditary hemochromatosis. J Hepatol. 2012; 57 (6): 1319-1325
    • (2012) J Hepatol , vol.57 , Issue.6 , pp. 1319-1325
    • Valenti, L.1    Fracanzani, A.L.2    Rametta, R.3
  • 33
    • 84902978429 scopus 로고    scopus 로고
    • Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis
    • Stickel F, Buch S, Zoller H, et al. Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis. Hum Mol Genet. 2014; 23 (14): 3883-3890
    • (2014) Hum Mol Genet , vol.23 , Issue.14 , pp. 3883-3890
    • Stickel, F.1    Buch, S.2    Zoller, H.3
  • 35
    • 84863209652 scopus 로고    scopus 로고
    • Hemophagocytic lymphohistiocytosis in adults: Diagnosis and treatment
    • Larroche C. Hemophagocytic lymphohistiocytosis in adults: diagnosis and treatment. Joint Bone Spine. 2012; 79 (4): 356-361
    • (2012) Joint Bone Spine , vol.79 , Issue.4 , pp. 356-361
    • Larroche, C.1
  • 36
    • 84902545015 scopus 로고    scopus 로고
    • Dysmetabolic iron overload syndrome: A systemic disease?
    • Deugnier Y, Laine F. Dysmetabolic iron overload syndrome: a systemic disease? Presse Med. 2014; 43 (6 Pt 1): 625-627
    • (2014) Presse Med , vol.43 , Issue.6 PT 1 , pp. 625-627
    • Deugnier, Y.1    Laine, F.2
  • 37
    • 79954550494 scopus 로고    scopus 로고
    • Iron-chelating therapy for transfusional iron overload
    • Musallam KM, Taher AT. Iron-chelating therapy for transfusional iron overload. N Engl J Med. 2011; 364 (15): 1476
    • (2011) N Engl J Med , vol.364 , Issue.15 , pp. 1476
    • Musallam, K.M.1    Taher, A.T.2
  • 38
    • 85018083083 scopus 로고    scopus 로고
    • Second international round robin for the quantification of serum non-Transferrin-bound iron and labile plasma iron in patients with iron-overload disorders
    • Sep 18 [Epub ahead of print]
    • de Swart L, Hendriks JC, van der Vorm LN, et al. Second International Round Robin for the Quantification of Serum Non-Transferrin-Bound Iron and Labile Plasma Iron in Patients with Iron-Overload Disorders. Haematologica. 2015 Sep 18. pii: haematol.2015.133983. [Epub ahead of print]
    • (2015) Haematologica
    • De Swart, L.1    Hendriks, J.C.2    Van Der Vorm, L.N.3
  • 39
    • 84866746601 scopus 로고    scopus 로고
    • Second round robin for plasma hepcidin methods: First steps toward harmonization
    • Kroot JJ, van Herwaarden AE, Tjalsma H, et al. Second round robin for plasma hepcidin methods: first steps toward harmonization. Am J Hematol. 2012; 87 (10): 977-983
    • (2012) Am J Hematol , vol.87 , Issue.10 , pp. 977-983
    • Kroot, J.J.1    Van Herwaarden, A.E.2    Tjalsma, H.3
  • 40
    • 84931578381 scopus 로고    scopus 로고
    • Estimating tissue iron burden: Current status and future prospects
    • Wood JC. Estimating tissue iron burden: current status and future prospects. Br J Haematol. 2015; 170 (1): 15-28
    • (2015) Br J Haematol , vol.170 , Issue.1 , pp. 15-28
    • Wood, J.C.1
  • 42
    • 11244355277 scopus 로고    scopus 로고
    • Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance
    • St Pierre TG, Clark PR, Chua-Anusorn W, et al. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood. 2005; 105 (2): 855-861
    • (2005) Blood , vol.105 , Issue.2 , pp. 855-861
    • St Pierre, T.G.1    Clark, P.R.2    Chua-Anusorn, W.3
  • 43
    • 0842283228 scopus 로고    scopus 로고
    • Non-invasive assessment of hepatic iron stores by MRI
    • Gandon Y, Olivie D, Guyader D, et al. Non-invasive assessment of hepatic iron stores by MRI. Lancet. 2004; 363 (9406): 357-362
    • (2004) Lancet , vol.363 , Issue.9406 , pp. 357-362
    • Gandon, Y.1    Olivie, D.2    Guyader, D.3
  • 44
    • 84960397668 scopus 로고    scopus 로고
    • EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochromatosis (HH)
    • jul 8. [Epub ahead of print]
    • Porto G, Brissot P, Swinkels DW, et al. EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochromatosis (HH). Eur J Hum Genet. 2015 Jul 8. doi: 10.1038/ejhg.2015.128. [Epub ahead of print]
    • (2015) Eur J Hum Genet
    • Porto, G.1    Brissot, P.2    Swinkels, D.W.3
  • 45
    • 84920948265 scopus 로고    scopus 로고
    • Aceruloplasminemia
    • Miyajima H. Aceruloplasminemia. Neuropathology. 2015; 35 (1): 83-90
    • (2015) Neuropathology , vol.35 , Issue.1 , pp. 83-90
    • Miyajima, H.1
  • 46
    • 80052657110 scopus 로고    scopus 로고
    • Pathology of hepatic iron overload
    • Deugnier Y, Turlin B. Pathology of hepatic iron overload. Semin Liver Dis. 2011; 31 (3): 260-271
    • (2011) Semin Liver Dis , vol.31 , Issue.3 , pp. 260-271
    • Deugnier, Y.1    Turlin, B.2
  • 47
    • 84929131683 scopus 로고    scopus 로고
    • Non-invasive assessment of liver fibrosis in C282Y homozygous HFE hemochromatosis
    • Legros L, Bardou-Jacquet E, Latournerie M, et al. Non-invasive assessment of liver fibrosis in C282Y homozygous HFE hemochromatosis. Liver Int. 2015; 35 (6): 1731-1738
    • (2015) Liver Int , vol.35 , Issue.6 , pp. 1731-1738
    • Legros, L.1    Bardou-Jacquet, E.2    Latournerie, M.3
  • 48
    • 84945457566 scopus 로고    scopus 로고
    • Next-generation sequencing: Application of a novel platform to analyze atypical iron disorders
    • nov. Epub 2015 Jul 4
    • McDonald CJ, Ostini L, Wallace DF, et al. Next-generation sequencing: Application of a novel platform to analyze atypical iron disorders. J Hepatol. 2015 Nov;63(5):1288-1293. doi: 10.1016/j.jhep.2015.06.027. Epub 2015 Jul 4
    • (2015) J Hepatol , vol.63 , Issue.5 , pp. 1288-1293
    • McDonald, C.J.1    Ostini, L.2    Wallace, D.F.3
  • 49
    • 0034601375 scopus 로고    scopus 로고
    • Hepatic iron concentration and total body iron stores in thalassemia major
    • Angelucci E, Brittenham GM, McLaren CE, et al. Hepatic iron concentration and total body iron stores in thalassemia major. N Engl J Med. 2000; 343 (5): 327-331
    • (2000) N Engl J Med , vol.343 , Issue.5 , pp. 327-331
    • Angelucci, E.1    Brittenham, G.M.2    McLaren, C.E.3
  • 50
    • 84861659662 scopus 로고    scopus 로고
    • French recommendations for management of HFE hemochromatosis
    • HAS. [Internet]. [cited 2005]. Available from
    • HAS. French recommendations for management of HFE hemochromatosis [Internet]. Haute Autorité de Santé. 2005 [cited 2005]. Available from: http://www.has-sante.fr
    • (2005) Haute Autorité de Santé
  • 51
    • 79958831498 scopus 로고    scopus 로고
    • Hereditary hemochromatosis: Patient experiences of the disease and phlebotomy treatment
    • Brissot P, Ball S, Rofail D, et al. Hereditary hemochromatosis: patient experiences of the disease and phlebotomy treatment. Transfusion. 2011; 51 (6): 1331-1338
    • (2011) Transfusion , vol.51 , Issue.6 , pp. 1331-1338
    • Brissot, P.1    Ball, S.2    Rofail, D.3
  • 52
    • 84930533358 scopus 로고    scopus 로고
    • Treatment of nongout joint deposition diseases: An update
    • Pascart T, Richette P, Flipo RM. Treatment of nongout joint deposition diseases: an update. Arthritis. 2014; 2014: 375202
    • (2014) Arthritis , vol.2014 , pp. 375202
    • Pascart, T.1    Richette, P.2    Flipo, R.M.3
  • 54
    • 84899484076 scopus 로고    scopus 로고
    • Iron chelation: An update
    • Sheth S. Iron chelation: an update. Cur Opin Hematol. 2014; 21 (3): 179-185
    • (2014) Cur Opin Hematol , vol.21 , Issue.3 , pp. 179-185
    • Sheth, S.1
  • 55
    • 84907927202 scopus 로고    scopus 로고
    • Randomized controlled trials of iron chelators for the treatment of cardiac siderosis in thalassaemia major
    • Baksi AJ, Pennell DJ. Randomized controlled trials of iron chelators for the treatment of cardiac siderosis in thalassaemia major. Front Pharmacol. 2014; 5: 217
    • (2014) Front Pharmacol , vol.5 , pp. 217
    • Baksi, A.J.1    Pennell, D.J.2
  • 56
    • 80052691105 scopus 로고    scopus 로고
    • Improvement in liver pathology of patients with beta-Thalassemia treated with deferasirox for at least 3 years
    • Deugnier Y, Turlin B, Ropert M, et al. Improvement in liver pathology of patients with beta-Thalassemia treated with deferasirox for at least 3 years. Gastroenterology. 2011; 141 (4): 1202-1211
    • (2011) Gastroenterology , vol.141 , Issue.4 , pp. 1202-1211
    • Deugnier, Y.1    Turlin, B.2    Ropert, M.3
  • 57
    • 78149306479 scopus 로고    scopus 로고
    • HJV hemochromatosis, iron overload, and hypogonadism in a Brazilian man: Treatment with phlebotomy and deferasirox
    • Santos PC, Cancado RD, Pereira AC, et al. HJV hemochromatosis, iron overload, and hypogonadism in a Brazilian man: treatment with phlebotomy and deferasirox. Acta Haematol. 2010; 124 (4): 204-205
    • (2010) Acta Haematol , vol.124 , Issue.4 , pp. 204-205
    • Santos, P.C.1    Cancado, R.D.2    Pereira, A.C.3
  • 58
    • 84886991697 scopus 로고    scopus 로고
    • Manipulation of the hepcidin pathway for therapeutic purposes
    • Fung E, Nemeth E. Manipulation of the hepcidin pathway for therapeutic purposes. Haematologica. 2013; 98 (11): 1667-1676
    • (2013) Haematologica , vol.98 , Issue.11 , pp. 1667-1676
    • Fung, E.1    Nemeth, E.2
  • 59
    • 84868545645 scopus 로고    scopus 로고
    • Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis
    • Ramos E, Ruchala P, Goodnough JB, et al. Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis. Blood. 2012; 120 (18): 3829-3836
    • (2012) Blood , vol.120 , Issue.18 , pp. 3829-3836
    • Ramos, E.1    Ruchala, P.2    Goodnough, J.B.3
  • 60
    • 84935029971 scopus 로고    scopus 로고
    • Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload
    • Aydinok Y, Kattamis A, Cappellini MD, et al. Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload. Blood. 2015; 125 (25): 3868-3877
    • (2015) Blood , vol.125 , Issue.25 , pp. 3868-3877
    • Aydinok, Y.1    Kattamis, A.2    Cappellini, M.D.3
  • 61
    • 84940782881 scopus 로고    scopus 로고
    • Efficacy and safety of a novel combination of two oral chelators deferasirox/deferiprone over deferoxamine/deferiprone in severely iron overloaded young beta thalassemia major patients
    • nov
    • Elalfy MS, Adly AM, Wali Y, et al. Efficacy and safety of a novel combination of two oral chelators deferasirox/deferiprone over deferoxamine/deferiprone in severely iron overloaded young beta thalassemia major patients. Eur J Haematol. 2015 Nov;95(5):411-420. doi: 10.1111/ejh.12507. Epub 2015 Mar 27
    • (2015) Eur J Haematol , vol.95 , Issue.5 , pp. 411-420
    • Elalfy, M.S.1    Adly, A.M.2    Wali, Y.3
  • 62
    • 84929154461 scopus 로고    scopus 로고
    • Reversal of hemochromatosis by apotransferrin in non-Transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice
    • Gelderman MP, Baek JH, Yalamanoglu A, et al. Reversal of hemochromatosis by apotransferrin in non-Transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice. Haematologica. 2015; 100 (5): 611-622
    • (2015) Haematologica , vol.100 , Issue.5 , pp. 611-622
    • Gelderman, M.P.1    Baek, J.H.2    Yalamanoglu, A.3
  • 63
    • 84925303329 scopus 로고    scopus 로고
    • Combination therapy with a Tmprss6 RNAi-Therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of beta-Thalassemia intermedia
    • Schmidt PJ, Racie T, Westerman M, et al. Combination therapy with a Tmprss6 RNAi-Therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of beta-Thalassemia intermedia. Am J Hematol. 2015; 90 (4): 310-313
    • (2015) Am J Hematol , vol.90 , Issue.4 , pp. 310-313
    • Schmidt, P.J.1    Racie, T.2    Westerman, M.3
  • 64
    • 84875118880 scopus 로고    scopus 로고
    • Protein antioxidants in thalassemia
    • Awadallah S. Protein antioxidants in thalassemia. Adv Clini Chem. 2013; 60: 85-128
    • (2013) Adv Clini Chem , vol.60 , pp. 85-128
    • Awadallah, S.1
  • 65
    • 84873991943 scopus 로고    scopus 로고
    • A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in beta-Thalassemia major patients receiving desferrioxamine
    • Moayedi B, Gharagozloo M, Esmaeil N, et al A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in beta-Thalassemia major patients receiving desferrioxamine. Eur J Haematol. 2013; 90 (3): 202-209
    • (2013) Eur J Haematol , vol.90 , Issue.3 , pp. 202-209
    • Moayedi, B.1    Gharagozloo, M.2    Esmaeil, N.3
  • 66
    • 84955745628 scopus 로고    scopus 로고
    • Resveratrol mediates therapeutic hepatic effects in acquired and genetic murine models of iron-overload
    • Jun 16 [Epub ahead of print]
    • Das SK, DesAulniers J, Dyck JR, et al. Resveratrol mediates therapeutic hepatic effects in acquired and genetic murine models of iron-overload. Liver Int. 2015 Jun 16. doi: 10.1111/liv.12893. [Epub ahead of print]
    • (2015) Liver Int
    • Das, S.K.1    DesAulniers, J.2    Dyck, J.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.