Eighty percent of French sport winners in Olympic, World and Europeans competitions have mutations in the hemochromatosis HFE gene

Biochimie

Volumn 119, Issue , 2015, Pages 1-5

  Hermine, Olivier ^a,b,c,d   Dine, Gérard ^a,e,f   Genty, Vincent ^f,g   Marquet, Laurie Anne ^a,k   Fumagalli, Gabriela ^f   Tafflet, Muriel ^a,d,h,k   Guillem, Flavia ^b,c,d   Van Lierde, Françoise ^f   Rousseaux Blanchi, Marie Philippe ⁱ   Palierne, Christian ^j,k   Lapostolle, Jean Claude ^k,l   Cervetti, Jean Pierre ^m   Frey, Alain ^k,n   Jouven, Xavier ^d,h   Noirez, Philippe ^a,d,k   Toussaint, Jean François ^a,d,k,o  

^a Sorbonne Paris Cité   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c AP HP Necker Enfants Malades   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e Ecole Centrale   (France)

^f IBT   (France)

^g Biotechnology Insitute of Troyes IBT ^*  (France)

^h PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

ⁱ French Ski Federation   (France)

^j French Rowing Federation (FFSA)   (France)

^k Institut National du Sport et de l'Education Physique   (France)

^l Archery French Federation Paris   (France)

^m Petanque French Federation   (France)

ⁿ Judo French Federation   (France)

^o HÔTEL DIEU   (France)

more..

Author keywords

Athlete; Gene; HFE mutation frequency; Iron

Indexed keywords

HEMOGLOBIN; HFE PROTEIN; TRANSFERRIN; TRANSFERRIN RECEPTOR; HEMOCHROMATOSIS PROTEIN; HFE PROTEIN, HUMAN;

ADULT; ALLELE; ARTICLE; ATHLETE; BLOOD TRANSFUSION; COMPETITION; CONTROLLED STUDY; ENERGY EXPENDITURE; EUROPEAN; FEMALE; GENE FREQUENCY; GENE MUTATION; GEOGRAPHIC ORIGIN; HEMOCHROMATOSIS; HETEROZYGOSITY; HUMAN; JUDO; MAJOR CLINICAL STUDY; MALE; MUSCLE FUNCTION; PHENOTYPE; ROWING; SKIING; ADOLESCENT; AMINO ACID SUBSTITUTION; ATHLETIC PERFORMANCE; ENDURANCE; FRANCE; GENETIC ASSOCIATION STUDY; GENETICS; HETEROZYGOTE; MARTIAL ART; METABOLISM; MIDDLE AGED; MUSCLE DEVELOPMENT; MUTATION; YOUNG ADULT;

ADOLESCENT; ADULT; ALLELES; AMINO ACID SUBSTITUTION; ATHLETES; ATHLETIC PERFORMANCE; FEMALE; FRANCE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HEMOCHROMATOSIS PROTEIN; HETEROZYGOTE; HUMANS; MALE; MARTIAL ARTS; MIDDLE AGED; MUSCLE DEVELOPMENT; MUTATION; PHYSICAL ENDURANCE; SKIING; YOUNG ADULT;

EID: 84944191535     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2015.09.028     Document Type: Article

References (20)

1. I. Ahmetov, and O. Fedotovskaya Sports genomics: current state of knowledge and future directions Cell. Mol. Exerc. Physiol. 1 2012 10.7457/cmep.v1i1.e1 e1
2. N. Yang, D.G. MacArthur, J.P. Gulbin, A.G. Hahn, A.H. Beggs, S. Easteal, and et al. ACTN3 genotype is associated with human elite athletic performance Am. J. Hum. Genet. 73 2003 627 631 10.1086/377590
3. P. Peeling, B. Dawson, C. Goodman, G. Landers, and D. Trinder Athletic induced iron deficiency: new insights into the role of inflammation, cytokines and hormones Eur. J. Appl. Physiol. 103 2008 381 391 10.1007/s00421-008-0726-6
4. S.D. Anker, J. Comin Colet, G. Filippatos, R. Willenheimer, K. Dickstein, H. Drexler, and et al. Ferric carboxymaltose in patients with heart failure and iron deficiency N. Engl. J. Med. 361 2009 2436 2448 10.1056/NEJMoa0908355
5. T. Ganz, and E. Nemeth Hepcidin and iron homeostasis Biochim. Biophys. Acta 1823 2012 1434 1443 10.1016/j.bbamcr.2012.01.014
6. S.K. Ganesh, N.A. Zakai, F.J.A. van Rooij, N. Soranzo, A.V. Smith, M.A. Nalls, and et al. Multiple loci influence erythrocyte phenotypes in the CHARGE consortium Nat. Genet. 41 2009 1191 1198 10.1038/ng.466
7. S.G. Zaloumis, K.J. Allen, N.A. Bertalli, L. Turkovic, M.B. Delatycki, A.J. Nicoll, and et al. The natural history of HFE simple heterozygosity for C282Y and H63D: a prospective twelve year study J. Gastroenterol. Hepatol. 2014 10.1111/jgh.12804
8. P. Ramos, E. Guy, N. Chen, C.C. Proenca, S. Gardenghi, C. Casu, and et al. Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis Blood 117 2011 1379 1389 10.1182/blood-2010-09-307462
9. J. Attia, J.P.A. Ioannidis, A. Thakkinstian, M. McEvoy, R.J. Scott, C. Minelli, and et al. How to use an article about genetic association: C: what are the results and will they help me in caring for my patients? JAMA J. Am. Med. Assoc. 301 2009 304 308 10.1001/jama.2008.993
10. A.V. Hill Muscular Activity 1926 Published for the Johns Hopkins University by Williams & Wilkins http://books.google.fr/books?id=IiNKAAAAMAAJ
11. E.H. Hanson, G. Imperatore, and W. Burke HFE gene and hereditary hemochromatosis: a HuGE review. Human genome epidemiology Am. J. Epidemiol. 154 2001 193 206
12. J.L. Chicharro, J. Hoyos, F. Gómez-Gallego, J.G. Villa, F. Bandrés, P. Celaya, and et al. Mutations in the hereditary haemochromatosis gene HFE in professional endurance athletes Br. J. Sports Med. 38 2004 418 421 10.1136/bjsm.2002.003921
13. P. Robach, G. Cairo, C. Gelfi, F. Bernuzzi, H. Pilegaard, A. Viganò, and et al. Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle Blood 109 2007 4724 4731 10.1182/blood-2006-08-040006
14. T.D. Brutsaert, S. Hernandez-Cordero, J. Rivera, T. Viola, G. Hughes, and J.D. Haas Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic women Am. J. Clin. Nutr. 77 2003 441 448
15. E. Franchini, F.B. Del Vecchio, K.A. Matsushigue, and G.G. Artioli Physiological profiles of elite judo athletes Sports Med. Auckl. N. Z. 41 2011 147 166 10.2165/11538580-000000000-00000
16. A.G. Williams, and J.P. Folland Similarity of polygenic profiles limits the potential for elite human physical performance J. Physiol. 586 2008 113 121 10.1113/jphysiol.2007.141887
17. A. de la Chapelle, A.L. Träskelin, and E. Juvonen Truncated erythropoietin receptor causes dominantly inherited benign human erythrocytosis Proc. Natl. Acad. Sci. U. S. A. 90 1993 4495 4499
18. Y. Deugnier, O. Loréal, F. Carré, A. Duvallet, F. Zoulim, J.P. Vinel, and et al. Increased body iron stores in elite road cyclists Med. Sci. Sports Exerc 34 2002 876 880
19. P. Schjerling Gene doping Scand. J. Med. Sci. Sports 18 2008 121 122 10.1111/j.1600-0838.2008.00806.x
20. R. Plomin, C.M.A. Haworth, and O.S.P. Davis Common disorders are quantitative traits Nat. Rev. Genet. 10 2009 872 878 10.1038/nrg2670