Loss of Gsα in the postnatal skeleton leads to low bone mass and a blunted response to anabolic parathyroid hormone therapy

Journal of Biological Chemistry

Volumn 291, Issue 4, 2016, Pages 1631-1642

  Sinha, Partha ^a   Aarnisalo, Piia ^a,b   Chubb, Rhiannon ^a   Poulton, Ingrid J ^c   Guo, Jun ^a   Nachtrab, Gregory ^a   Kimura, Takaharu ^d   Swami, Srilatha ^d   Saeed, Hamid ^d   Chen, Min ^e   Weinstein, Lee S ^e   Schipani, Ernestina ^f   Sims, Natalie A ^c   Kronenberg, Henry M ^a   Wu, Joy Y ^a,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^f UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALS; OSTEOBLASTS; PROTEINS;

BONE FORMATION RATES; CONSTITUTIVELY ACTIVES; G PROTEIN COUPLED RECEPTORS; OSTEOBLAST DIFFERENTIATION; OSTEOBLAST FUNCTION; PARATHYROID HORMONES; PHOSPHOLIPASE C ACTIVATIONS; SIGNALING PATHWAYS;

BONE;

ADENYLATE CYCLASE; BETA ARRESTIN; CRE RECOMBINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOXYCYCLINE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR 1; PARATHYROID HORMONE[1-34]; PHOSPHOLIPASE C; SCLEROSTIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; WNT PROTEIN; ANABOLIC AGENT; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DENSITY; BONE MASS; CELL DIFFERENTIATION; CELL EXPANSION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FRAGILITY FRACTURE; HISTOPATHOLOGY; MALE; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; NEWBORN; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; OSTEOPOROSIS; PARATHYROID HORMONE BLOOD LEVEL; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TRABECULAR BONE; ANIMAL; BONE; BONE DEVELOPMENT; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HORMONE SUBSTITUTION; HUMAN; METABOLISM; PATHOPHYSIOLOGY;

ANABOLIC AGENTS; ANIMALS; BONE AND BONES; BONE DEVELOPMENT; CELL DIFFERENTIATION; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HORMONE REPLACEMENT THERAPY; HUMANS; MALE; MICE; OSTEOBLASTS; OSTEOPOROSIS; PARATHYROID HORMONE; RECEPTOR, PARATHYROID HORMONE, TYPE 1;

EID: 84959019116     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.679753     Document Type: Article

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