PADI4 polymorphism predisposes male smokers to rheumatoid arthritis

Annals of the Rheumatic Diseases

Volumn 70, Issue 3, 2011, Pages 512-515

  Kochi, Yuta ^a   Thabet, Mohamed M ^b   Suzuki, Akari ^a   Okada, Yukinori ^c   Daha, Nina A ^b   Toes, René E M ^b   Huizinga, Tom W J ^b   Myouzen, Keiko ^a   Kubo, Michiaki ^a   Yamada, Ryo ^d   Nakamura, Yusuke ^e   Yamamoto, Kazuhiko ^c  

^a RIKEN   (Japan)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF TOKYO   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN ARGININE DEIMINASE; PROTEIN ARGININE DEIMINASE 4; UNCLASSIFIED DRUG;

ARTICLE; ASIAN; CAUCASIAN; CONTROLLED STUDY; DNA POLYMORPHISM; ETHNIC DIFFERENCE; FEMALE; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SMOKING;

ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYDROLASES; JAPAN; MALE; NETHERLANDS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX FACTORS; SMOKING;

EID: 79951515173     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2010.130526     Document Type: Article

References (22)

1. Plenge RM. Recent progress in rheumatoid arthritis genetics: one step towards improved patient care. Curr Opin Rheumatol 2009;21:262-71.
2. Suzuki A, Yamada R, Chang X, et al. Functional haplotypes of PADI4 , encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet 2003;34:395-402. (Pubitemid 36935332)
3. Klareskog L, Rönnelid J, Lundberg K, et al. Immunity to citrullinated proteins in rheumatoid arthritis. Annu Rev Immunol 2008;26:651-75. (Pubitemid 351600388)
4. Ikari K, Kuwahara M, Nakamura T, et al. Association between PADI4 and rheumatoid arthritis: a replication study. Arthritis Rheum 2005;52:3054-7. (Pubitemid 41447085)
5. Kang CP, Lee HS, Ju H, et al. A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans. Arthritis Rheum 2006; 54 :90-6. (Pubitemid 43122191)
6. Lee YH, Rho YH, Choi SJ, et al. PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis. Rheumatol Int 2007;27:827-33. (Pubitemid 46906647)
7. Burr ML, Naseem H, Hinks A, et al. PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population. Ann Rheum Dis 2010; 69 :666-70.
8. Plenge RM, Padyukov L, Remmers EF, et al. Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4 , and PADI4. Am J Hum Genet 2005;77:1044-60. (Pubitemid 41698524)
9. Hoppe B, Häupl T, Egerer K, et al. Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis. Ann Rheum Dis 2009;68:898-903.
10. Baka Z, Buzás E, Nagy G. Rheumatoid arthritis and smoking: putting the pieces together. Arthritis Res Ther 2009;11:238.
11. Klareskog L, Stolt P, Lundberg K, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006;54:38-46. (Pubitemid 43122184)
12. Makrygiannakis D, Hermansson M, Ulfgren AK, et al. Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells. Ann Rheum Dis 2008;67:1488-92.
13. Nakamura Y. The BioBank Japan Project. Clin Adv Hematol Oncol 2007;5:696-7. (Pubitemid 351699412)
14. Kurreeman FA, Padyukov L, Marques RB, et al. A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis. PLoS Med 2007;4:e278.
15. Woolf B. On estimating the relation between blood group and disease. Ann Hum Genet 1955;19:251-3.
16. Cordell HJ. Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet 2009;10:392-404.
17. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81 :559-75. (Pubitemid 47330214)
18. OECD Health Data. 2009. http://www.oecd.org/els/health/data.
19. Mattey DL, Dawes PT, Clarke S, et al. Relationship among the HLA-DRB1 shared epitope, smoking, and rheumatoid factor production in rheumatoid arthritis. Arthritis Rheum 2002;47:403-7. (Pubitemid 34856129)
20. Kallberg H, Padyukov L, Plenge RM, et al. Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22 , and smoking in two subsets of rheumatoid arthritis. Am J Hum Genet 2007;80:867-75. (Pubitemid 46668455)
21. Masi AT, Aldag JC, Chatterton RT. Sex hormones and risks of rheumatoid arthritis and developmental or environmental influences. Ann N Y Acad Sci 2006;1069:223-35. (Pubitemid 43989865)
22. Payne S. 'Smoke like a man, die like a man'?: a review of the relationship between gender, sex and lung cancer. Soc Sci Med 2001;53:1067-80.