Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway

ACS Medicinal Chemistry Letters

Volumn 7, Issue 2, 2016, Pages 182-187

  Alverez, Celeste ^a   Bulfer, Stacie L ^b   Chakrasali, Ramappa ^c   Chimenti, Michael S ^b   Deshaies, Raymond J ^d   Green, Neal ^e   Kelly, Mark ^b   LaPorte, Matthew G ^a   Lewis, Taber S ^a   Liang, Mary ^a   Moore, William J ^e   Neitz, R Jeffrey ^b   Peshkov, Vsevolod A ^a   Walters, Michael A ^c   Zhang, Feng ^a   Arkin, Michelle R ^b   Wipf, Peter ^a   Huryn, Donna M ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

AAA ATPase; allosteric inhibitor; indole amide; p97 inhibitor; protein homeostasis; ubiquitin pathway modulator

Indexed keywords

AMIDE; INDOLE DERIVATIVE; PROTEIN INHIBITOR; PROTEIN P97; UBIQUITIN;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CONTROLLED STUDY; COVALENT BOND; DRUG HALF LIFE; DRUG MECHANISM; DRUG SOLUBILITY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; METABOLIC STABILITY; MICHAELIS MENTEN KINETICS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHASE 1 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

EID: 84958981767     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00396     Document Type: Article

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