Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97

ACS Medicinal Chemistry Letters

Volumn 6, Issue 12, 2015, Pages 1225-1230

  Alverez, Celeste ^a   Arkin, Michelle R ^b   Bulfer, Stacie L ^b   Colombo, Raffaele ^a   Kovaliov, Marina ^a   Laporte, Matthew G ^a   Lim, Chaemin ^a   Liang, Mary ^a   Moore, William J ^c   Neitz, R Jeffrey ^b   Yan, Yongzhao ^a   Yue, Zhizhou ^a   Huryn, Donna M ^a   Wipf, Peter ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

AAA ATPase; fluorinated substituent effects; p97 inhibitors; pentafluorosulfanyl indole; structure activity relationships; trifluoromethyl indole

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; INDOLE DERIVATIVE; PENTAFLUOROSULFANYL INDOLE DERIVATIVE; PROTEIN P97; TRIFLUOROMETHYL INDOLE DERIVATIVE; UNCLASSIFIED DRUG; VALOSIN CONTAINING PROTEIN;

ALKYLATION; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; IC50; LIPOPHILICITY; MEDICINAL CHEMISTRY; NITRATION; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 84949792378     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00364     Document Type: Article

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