Blood flow visualization and measurements in microfluidic devices fabricated by a micromilling technique

Micro and Nanosystems

Volumn 7, Issue 3, 2015, Pages 148-153

  Singhal, Jaron ^a   Pinho, Diana ^b,c   Lopes, Raquel ^b   Sousa, Patricia C ^c   Garcia, Valdemar ^b   Schütte, Helmut ^a   Lima, Rui ^b,c,d   Gassmann, Stefan ^a  

^a JADE UNIVERSITY OF APPLIED SCIENCES   (Germany)

^b INSTITUTO POLITÉCNICO DE BRAGANÇA   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d UNIVERSITY OF MINHO   (Portugal)

Author keywords

Biomedical applications; Blood cells; Cell free layer; Cells separation; Microfluidic devices; Micromilling

Indexed keywords

BLOOD; CELLS; CYTOLOGY; FABRICATION; FLOW VISUALIZATION; FLUIDIC DEVICES; HIGH SPEED CAMERAS; MEDICAL APPLICATIONS; MICROMACHINING; MILLING (MACHINING);

BIOMEDICAL APPLICATIONS; BLOOD CELLS; CELL-FREE; MICRO MILLING; MICRO-FLUIDIC DEVICES;

MICROFLUIDICS;

EID: 84958970875     PISSN: 18764029     EISSN: 18764037     Source Type: Journal    
DOI: 10.2174/1876402908666160106000332     Document Type: Article

References (26)

1. Thiriet, M. Biology and mechanics of blood flows. Springer, 2008, New York.
2. Rodrigues, R. O.; Pinho, D.; Faustino, V.; Lima, R. A simple microfluidic device for the deformability assessment of blood cells in a continuous flow. Biomed. Microdevices, 2015, 17(6), 108.
3. Fujiwara, H.; Ishikawa, T.; Lima, R. Red blood cell motions in high-hematocrit blood flowing through a stenosed microchannel. J. Biomech., 2009, 42, 838-843.
4. Leble, V.; Lima, R.; Dias, R.; Fernandes, C.; Ishikawa, T.; Imai, Y.; Yamaguchi, T. Asymmetry of red blood cell motions in a microchannel with a diverging and converging bifurcation. Biomicrofluidics, 2011, 5, 044120.
5. Faivre, M.; Abkarian, M.; Bickraj, K. Stone HA Geometrical focusing of cells in a microfluidic device: An approach to separate blood plasma. Biorheology, 2006, 43, 147-159.
6. Sollier, E.; Cubizolles, M.; Fouillet, Y.; Achard, J. L. Fast and continuous plasma extraction from whole human blood based on expanding cell-free layer devices. Biomed. Microdevices, 2010, 12 485-497.
7. Pinho, D.; Yaginuma, T.; Lima, R. A microfluidic device for partial cell separation and deformability assessment. BioChip J., 2013, 7(4), 367-374.
8. Lima, R.; Wada, S.; Tanaka, S, Takeda M, Ishikawa T, Tsubota K, Imai Y, Yamaguchi T. In vitro blood flow in a rectangular pdms microchannel: Experimental observations using a confocal micropiv system. Biomed. Microdevices, 2008, 10, 153-167.
9. Yaginuma, T.; Oliveira, M. S.; Lima, R.; Ishikawa, T.; Yamaguchi, T. Human red blood cell behavior under homogeneous extensional flow in a hyperbolic-shaped microchannel. Biomicrofluidics, 2013, 7, 54110.
10. Pinto, E.; Faustino, V.; Rodrigues, R. O.; Pinho, D.; Garcia, V.; Miranda, J. M.; Lima, R. A Rapid and Low-Cost Nonlithographic Method to Fabricate Biomedical Microdevices for Blood Flow Analysis. Micromachines, 2015, 6, 121-135.
11. Bartholomeusz, D. A.; Boutte, R. W.; Andrade, J. D. Xurography: Rapid prototyping of microstructures using a cutting plotter. J. Microelectromech. Syst., 2005, 14, 1364-1374.
12. Tan, A.; Rodgers, K.; Murrihy, J.; O'Mathuna, C.; Glennon, J. D. Rapid fabrication of microfluidic devices in poly(dimethylsiloxane) by photocopying. Lab Chip, 2001, 1, 7-9.
13. Branham, M. L.; Tran-Son-Tay, R.; Schoonover, C.; Davis, P. S.; Allen, S. D.; Shyy, W. Rapid prototyping of micropatterned substrates using conventional laser printers. J. Mater. Res., 2002, 17, 1559-1562.
14. Bonyár, A.; Sántha, H.; Ring, B.; Varga, M.; Gábor Kovács, J.; Harsányi, G. 3D rapid prototyping technology (rpt) as a powerful tool in microfluidic development. Procedia Eng. 2010, 5, 291-294.
15. Rodrigues, R. O.; Lima, R.; Gomes, HT.; Silva, A. M. T. Polymer microfluidic devices: an overview of fabrication methods. U. Porto J. Eng., 2015, 1(1), 67-67.
16. Faustino, V.; Catarino, S. O.; Lima, R.; Minas, G. Biomedical microfluidic devices by using low-cost fabrication techniques: a review. J. Biomech., 2016 (in press).
17. Calejo, J.; Pinho, D.; Galindo-Rosales, F. J.; Lima, R.; Campo-Deaño, L. Particulate blood analogues reproducing the erythrocytes cell-free layer in a microfluidic device containing a hyperbolic contraction. Micromachines, 2016, 7, 4.
18. Maeda, N.; Suzuki, Y.; Tanaka, J.; Tateishi, N. Erythrocyte flow and elasticity of microvessels evaluated by marginal cell-free layer and flow resistance. Am. J. Physiol., 1996, 271, 2454-2461.
19. Lima, R.; Ishikawa, T.; Imai, Y.; Yamaguchi, T. Blood flow behavior in microchannels: advances and future trends. In: Ricardo D. M, Rui L, Antonio A, Teresa M. M. Eds.; Single and two-phase flows on chemical and biomedical engineering. Bentham Sci., 2012, pp 513-547.
20. Kim, S.; Ong, P. K.; Yalcin, O.; Intaglietta, M.; Johnson, P. C. The cell-free layer in microvascular blood flow. Biorheology, 2009, 46, 181-189.
21. Garcia, V.; Dias, R.; Lima, R. In Vitro Blood Flow Behaviour in Microchannels with Simple and Complex Geometries, In: Naik, G. R. Ed.; Applied Biological Engineering-Principles and Practice. 2012, InTech, pp. 393-416.
22. Lopes, R.; Rodrigues, R. O.; Pinho, D.; Garcia, V.; Schutte, H.; Lima, R.; Gassmann, S. Low cost microfluidic device for partial cell separation: micromilling approach. in Proceedings of 2015 IEEE International Conference on Industrial Technology, Seville, Spain.
23. Meijering, E.; Smal, I.; Danuser, G. Tracking in molecular bioimaging. IEEE Signal Process Mag., 2006, 23, 46-53.
24. Pinho, D.; Gayubo, F.; Pereira, A. I.; Lima, R. A comparison between a manual and automatic method to characterize red blood cell trajectories. Int. J. Num Methods Biomed. Eng., 2013, 29(9), 977-987.
25. Abramoff, M. D.; Magalhaes, P. J.; Ram, S. J. Image Processing with ImageJ. Biophotonics Int., 2004, 11, 36-42.
26. Rodrigues, R. O.; Lopes, R.; Pinho, D.; Pereira, A. I.; Garcia, V.; Gassmann, S.; Sousa, P. C.; Lima, R. In Vitro Blood Flow and Cell-Free Layer in Hyperbolic Microchannels: Visualizations and Measurements. BioChip J., 2016 [Epub ahead of Print].