Long noncoding RNA AFAP1-AS1 indicates a poor prognosis of hepatocellular carcinoma and promotes cell proliferation and invasion via upregulation of the RhoA/Rac2 signaling

International Journal of Oncology

Volumn 48, Issue 4, 2016, Pages 1590-1598

  Zhang, Jin Yan ^a   Weng, Ming Zhe ^a   Song, Fang Bin ^a   Xu, Yong Gang ^a   Liu, Qi ^a   Wu, Jun Yi ^a   Qin, Jun ^a   Jin, Tao ^a   Xu, Jun Ming ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

AFAP1 AS1; growth; hepatocellular carcinoma; invasion; long noncoding RNA

Indexed keywords

AFAP1 AS1 PROTEIN; LONG UNTRANSLATED RNA; ONCOPROTEIN; RAC2 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; AFAP1-AS1 LONG NONCODING RNA, HUMAN; RAC PROTEIN; RHOA PROTEIN, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LYMPH VESSEL METASTASIS; MAJOR CLINICAL STUDY; MOUSE; MTT ASSAY; NONHUMAN; NUDE MOUSE; OVERALL SURVIVAL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; TUMOR INVASION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CANCER TRANSPLANTATION; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; HEP-G2 CELL LINE; LIVER TUMOR; MALE; METABOLISM; PATHOLOGY; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR CELL LINE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MALE; MICE; NEOPLASM TRANSPLANTATION; PROGNOSIS; RAC GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; RNA, LONG NONCODING; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; UP-REGULATION;

EID: 84958952106     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2016.3385     Document Type: Article

References (41)

1. Rinella ME. Nonalcoholic fatty liver disease: A systematic review. JAMA. 313: 2263-2273, 2015.
2. Mancuso A, and Perricone G. Hepatocellular Carcinoma, and Liver Transplantation: State of the Art. J Clin Transl Hepatol. 2: 176-181, 2014.
3. Khan FZ, Perumpail RB, Wong RJ, and Ahmed A. Advances in hepatocellular carcinoma: Nonalcoholic steatohepatitis-related hepatocellular carcinoma. World J Hepatol. 7: 2155-2161, 2015.
4. She WH, and Chok KS. Strategies to increase the resectability of hepatocellular carcinoma. World J Hepatol. 7: 2147-2154, 2015.
5. Meng X, Franklin DA, Dong J, and Zhang Y. MDM2-p53 pathway in hepatocellular carcinoma. Cancer Res. 74: 7161-7167, 2014.
6. Watson ME, Diepeveen LA, Stubbs KA, and Yeoh GC. Glycosylation-related diagnostic, and therapeutic drug target markers in hepatocellular carcinoma. J Gastrointestin Liver Dis. 24: 349-357, 2015.
7. Wilusz JE, Sunwoo H, and Spector DL. Long noncoding RNAs: Functional surprises from the RNA world. Genes Dev. 23: 1494-1504, 2009.
8. Kim ED, and Sung S. Long noncoding RNA Unveiling hidden layer of gene regulatory networks. Trends Plant Sci. 17: 16-21, 2012.
9. Yoon JH, Abdelmohsen K, and Gorospe M. Posttranscriptional gene regulation by long noncoding RNA. J Mol Biol. 425: 3723-3730, 2013.
10. Yu TT, Xu XM, Hu Y, Deng JJ, Ge W, Han NN, and Zhang MX. Long noncoding RNAs in hepatitis B virus-related hepatocellular carcinoma. World J Gastroenterol. 21: 7208-7217, 2015.
11. Tu ZQ, Li RJ, Mei JZ, and Li XH. Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma. Int J Clin Exp Pathol. 7: 4303-4309, 2014.
12. Zhang X, Rice K, Wang Y, Chen W, Zhong Y, Nakayama Y, Zhou Y, and Klibanski A. Maternally expressed gene 3 (MEG3) noncoding ribonucleic acid: Isoform structure, expression and functions. Endocrinology. 151: 939-947, 2010.
13. Zhuo H, Tang J, Lin Z, Jiang R, Zhang X, Ji J, Wang P, and Sun B. The aberrant expression of MEG3 regulated by UHRF1 predicts the prognosis of hepatocellular carcinoma. Mol Carcinog Epub: Jan 16, 2015 (Epub ahead of print). doi: 10.1002/mc.22270.
14. Huang JF, Guo YJ, Zhao CX, Yuan SX, Wang Y, Tang GN, Zhou WP, and Sun SH. Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin. Hepatology. 57: 1882-1892, 2013.
15. Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, Zhang F, and Zheng SS. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol. 18: 1243-1250, 2011.
16. Lai MC, Yang Z, Zhou L, Zhu QQ, Xie HY, Zhang F, Wu LM, Chen LM, and Zheng SS. Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol. 29: 1810-1816, 2012.
17. Yang F, Zhang L, Huo XS, Yuan JH, Xu D, Yuan SX, Zhu N, Zhou WP, Yang GS, Wang YZ, et al. Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology. 54: 1679-1689, 2011.
18. Yuan SX, Yang F, Yang Y, Tao QF, Zhang J, Huang G, Yang Y, Wang RY, Yang S, Huo XS, et al. Long noncoding RNA associated with microvascular invasion in hepatocellular carcinoma promotes angiogenesis, and serves as a predictor for hepatocellular carcinoma patients' poor recurrence-free survival after hepatectomy. Hepatology. 56: 2231-2241, 2012.
19. Du Y, Kong G, You X, Zhang S, Zhang T, Gao Y, Ye L, and Zhang X. Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem. 287: 26302-26311, 2012.
20. Wu W, Bhagat TD, Yang X, Song JH, Cheng Y, Agarwal R, Abraham JM, Ibrahim S, Bartenstein M, Hussain Z, et al. Hypomethylation of noncoding DNA regions, and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus, and esophageal adenocarcinoma. Gastroenterology. 144: 956-966.e4, 2013.
21. Ye Y, Chen J, Zhou Y, Fu Z, Zhou Q, Wang Y, Gao W, Zheng S, Zhao X, Chen T, et al. High expression of AFAP1-AS1 is associated with poor survival, and short-Term recurrence in pancreatic ductal adenocarcinoma. J Transl Med. 13: 137, 2015.
22. Bo H, Gong Z, Zhang W, Li X, Zeng Y, Liao Q, Chen P, Shi L, Lian Y, Jing Y, et al. Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression, and poor prognosis of nasopharyngeal carcinoma. Oncotarget. 6: 20404-20418, 2015.
23. Zeng Z, Bo H, Gong Z, Lian Y, Li X, Li X, Zhang W, Deng H, Zhou M, Peng S, et al. AFAP1-AS1, a long noncoding RNA upregulated in lung cancer, and promotes invasion, and metastasis. Tumour Biol: Aug 6, 2015 (Epub ahead of print
24. Sun J, Bie B, Zhang S, Yang J, and Li Z. Long non-coding RNAs: Critical players in hepatocellular carcinoma. Int J Mol Sci. 15: 20434-20448, 2014.
25. Li CH, and Chen Y. Targeting long non-coding RNAs in cancers: Progress, and prospects. Int J Biochem Cell Biol. 45: 1895-1910, 2013.
26. Gutschner T, and Diederichs S. The hallmarks of cancer: A long non-coding RNA point of view. RNA Biol. 9: 703-719, 2012.
27. Iranpour M, Soudyab M, Geranpayeh L, Mirfakhraie R, Azargashb E, Movafagh A, and Ghafouri-Fard S. Expression analysis of four long noncoding RNAs in breast cancer. Tumour Biol: Sep 27, 2015 (Epub ahead of print
28. Tang Q, Ni Z, Cheng Z, Xu J, Yu H, and Yin P. Three circulating long non-coding RNAs act as biomarkers for predicting NSCLC. Cell Physiol Biochem. 37: 1002-1009, 2015.
29. Zhou M, Hou Y, Yang G, Zhang H, Tu G, Du YE, Wen S, Xu L, Tang X, Tang S, et al. LncRNA-Hh strengthen cancer stem cells generation in twist-positive breast cancer via activation of Hedgehog signaling pathway. Stem Cells: Sept 29, 2015 (Epub ahead of print). doi: 10.1002/stem.2219.
30. Zhang A, Zhao JC, Kim J, Fong KW, Yang YA, Chakravarti D, Mo YY, and Yu J. LncRNA HOTAIR enhances the androgenreceptor-mediated transcriptional program, and drives castration-resistant prostate cancer. Cell Rep. 13: 209-221, 2015.
31. Lu L, Luo F, Liu Y, Liu X, Shi L, Lu X, and Liu Q. Posttranscriptional silencing of the lncRNA MALAT1 by miR-217 inhibits the epithelial-mesenchymal transition viaenhancer of zeste homolog 2 in the malignant transformation of HBE cells induced by cigarette smoke extract. Toxicol Appl Pharmacol. 289: 276-285, 2015.
32. Xie M, Sun M, Zhu YN, Xia R, Liu YW, Ding J, Ma HW, He XZ, Zhang ZH, Liu ZJ, et al. Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDTT3 expression. Oncotarget. 6: 33587-33601, 2015.
33. Naemura M, Murasaki C, Inoue Y, Okamoto H, and Kotake Y. Long noncoding RNA ANRIL regulates proliferation of non-small cell lung cancer, and cervical cancer cells. Anticancer Res. 35: 5377-5382, 2015.
34. Zhang CL, Zhu KP, Shen GQ, and Zhu ZS. A long non-coding RNA contributes to doxorubicin resistance of osteosarcoma. Tumour Biol: Sep 25, 2015 (Epub ahead of print
35. Yu OM, and Brown JH. G protein-coupled receptor, and RhoAstimulated transcriptional responses: Links to inflammation, differentiation and cell proliferation. Mol Pharmacol. 88: 171-180, 2015.
36. Yin K, Zhao G, Huang X, Gao G, Sun H, Wei Q, Liu Q, Li M, Xu C, Zhu S, et al. Inhibition of RhoA expression by adenovirusmediated siRNA combined with TNF-A induced apoptosis of hepatocarcinoma cells. Biomed Mater Eng 26 (Suppl 1): S2055-S2067, 2015.
37. Serizawa N, Tian J, Fukada H, Baghy K, Scott F, Chen X, Kiss Z, Olson K, Hsu D, Liu FT, et al. Galectin 3 regulates HCC cell invasion by RhoA, and MLCK activation. Lab Invest. 95: 1145-1156, 2015.
38. Lin L, Yang XM, Li J, Zhang YL, Qin W, and Zhang ZG. Microfilament regulatory protein MENA increases activity of RhoA, and promotes metastasis of hepatocellular carcinoma. Exp Cell Res. 327: 113-122, 2014.
39. Wong CM, Wei L, Au SL, Fan DN, Zhou Y, Tsang FH, Law CT, Lee JM, He X, Shi J, et al. MiR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis. Oncotarget. 6: 13658-13670, 2015.
40. Gu DL, Chen YH, Shih JH, Lin CH, Jou YS, and Chen CF. Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma. World J Gastroenterol. 19: 8873-8879, 2013.
41. Cleary SP, Jeck WR, Zhao X, Chen K, Selitsky SR, Savich GL, Tan TX, Wu MC, Getz G, Lawrence MS, et al. Identification of driver genes in hepatocellular carcinoma by exome sequencing. Hepatology. 58: 1693-1702, 2013.