Microfilament regulatory protein MENA increases activity of RhoA and promotes metastasis of hepatocellular carcinoma

Experimental Cell Research

Volumn 327, Issue 1, 2014, Pages 113-122

  Lin, Ling ^a   Yang, Xiao Mei ^a   Li, Jun ^a   Zhang, Yan Li ^a   Qin, Wenxin ^a   Zhang, Zhi Gang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Actin bundles; Hepatocellular carcinoma; Invadopodia; MENA; RhoA

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; DIMETHYL SULFOXIDE; F ACTIN; MENA PROTEIN; REGULATOR PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RECURRENCE; CELL MOTILITY; CELL STRESS; CONTROLLED STUDY; DISTANT METASTASIS; ENZYME ACTIVITY; FEMALE; GENE SILENCING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION;

MAMMALIA;

ACTIN BUNDLES; HEPATOCELLULAR CARCINOMA; INVADOPODIA; MENA; RHOA;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MICE, INBRED BALB C; MICROFILAMENT PROTEINS; MIDDLE AGED; NEOPLASM METASTASIS; RHOA GTP-BINDING PROTEIN;

EID: 84906934319     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2014.05.010     Document Type: Article

References (25)

1. Forner A., Llovet J.M., Bruix J. Hepatocellular carcinoma. Lancet 2012, 379:1245-1255.
2. Ferlay J., Shin H.R., Bray F. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 2010, 127:2893-2917.
3. Wong C.C., Wong C.M., Au S.L. RhoGTPases and Rho-effectors in hepatocellular carcinoma metastasis: ROCK N[U+05F3]Rho move it. Liver Int. 2010, 30:642-656.
4. Grise F., Bidaud A., Moreau V. Rho GTPases in hepatocellular carcinoma. BBA Rev. Cancer 2009, 1795:137-151.
5. Krause M., Dent E.W., Bear J.E. Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annu. Rev. Cell Dev. Biol. 2003, 19:541-564.
6. Gertler F.B., Niebuhr K., Reinhard M. MENA, a relative of VASP and drosophila enabled, is implicated in the control of microfilament dynamics. Cell 1996, 87:227-239.
7. Huttelmaier S., Harbeck B., Steffens O. Characterization of the actin binding properties of the vasodilator-stimulated phosphoprotein VASP. FEBS Lett. 1999, 451:68-74.
8. Bachmann C., Fischer L., Walter U. The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation. J. Biol. Chem. 1999, 274:23549-23557.
9. Scott J.A., Shewan A.M., den Elzen N.R. Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts. Mol. Biol. Cell 2006, 17:1085-1095.
10. Gertler F., Condeelis J. Metastasis: tumor cells becoming MENAcing. Trends Cell Biol. 2011, 21:81-90.
11. Bear J.E., Gertler F.B. Ena/VASP: towards resolving a pointed controversy at the barbed end. J. Cell Sci. 2009, 122:1947-1953.
12. Gupton S.L., Riquelme D., Hughes-Alford S.K. Mena binds alpha5 integrin directly and modulates alpha5beta1 function. J. Cell Biol. 2012, 198:657-676.
13. Tanoue T., Takeichi M. Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J. Cell Biol. 2004, 165:517-528.
14. Toyoda A., Kawana H., Azuhata K. Aberrant expression of human ortholog of mammalian enabled (hMena) in human colorectal carcinomas: implications for its role in tumor progression. Int. J. Oncol. 2009, 34:53-60.
15. Gurzu S., Jung I., Prantner I., Chira L. The immunohistochemical aspects of protein Mena in cervical lesions. Rom. J. Morphol. Embryol. 2009, 50:213-216.
16. Di Modugno F., Mottolese M., Di Benedetto A. The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors. Clin. Cancer Res. 2006, 12:1470-1478.
17. Philippar U., Roussos E.T., Oser M. A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev. Cell 2008, 15:813-828.
18. Roussos E.T., Balsamo M., Alford S.K. Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J. Cell Sci. 2011, 124:2120-2131.
19. Bustin S.A., Benes V., Garson J.A. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 2009, 55:611-622.
20. Schmitz A.A., Govek E.E., Bottner B. Rho GTPases: signaling, migration, and invasion. Exp. Cell Res. 2000, 261:1-12.
21. Olson M.F. Applications for ROCK kinase inhibition. Curr. Opin. Cell Biol. 2008, 20:242-248.
22. Robinson B.D., Sica G.L., Liu Y.F. Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clin. Cancer Res. 2009, 15:2433-2441.
23. Bishop A.L., Hall A. Rho GTPases and their effector proteins. Biochem. J. 2000, 348(Pt 2):241-255.
24. Takenawa T., Miki H. WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J. Cell Sci. 2001, 114:1801-1809.
25. Radhakrishna H., Al-Awar O., Khachikian Z. ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements. J. Cell Sci. 1999, 112(Pt 6):855-866.