Aerobic glycolysis in the frontal cortex correlates with memory performance in wild-type mice but not the APP/PS1 mouse model of cerebral amyloidosis

Journal of Neuroscience

Volumn 36, Issue 6, 2016, Pages 1871-1878

  Harris, Richard A ^a   Tindale, Lauren ^a   Lone, Asad ^a   Singh, Olivia ^a   Macauley, Shannon L ^b   Stanley, Molly ^b   Holtzman, David M ^b   Bartha, Robert ^c   Cumming, Robert C ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Aerobic glycolysis; Alzheimer s disease; Amyloid; Lactate; Magnetic resonance spectroscopy; Memory

Indexed keywords

AMYLOID BETA PROTEIN; LACTATE DEHYDROGENASE; LACTATE TRANSPORTER; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 2; MONOCARBOXYLATE TRANSPORTER 4; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE KINASE; UNCLASSIFIED DRUG; AMYLOID PRECURSOR PROTEIN; MONOCARBOXYLATE TRANSPORTER; PRESENILIN 1; PRESENILIN 1, MOUSE;

AGE; AMYLOID PLAQUE; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN INTERSTITIAL FLUID; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FRONTAL CORTEX; GLYCOLYSIS; HIPPOCAMPAL NEURONAL CULTURE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MEMORY TEST; MORRIS WATER MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; SPATIAL MEMORY; WESTERN BLOTTING; AEROBIC METABOLISM; AGING; ANIMAL; BRAIN CHEMISTRY; C57BL MOUSE; ENZYMOLOGY; FRONTAL LOBE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HIPPOCAMPUS; MEMORY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; TRANSGENIC MOUSE;

AEROBIOSIS; AGING; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOIDOSIS; ANIMALS; ASTROCYTES; BRAIN CHEMISTRY; FRONTAL LOBE; GLYCOLYSIS; HIPPOCAMPUS; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MEMORY; MICE, INBRED C57BL; MICE, TRANSGENIC; MONOCARBOXYLIC ACID TRANSPORTERS; PRESENILIN-1; PSYCHOMOTOR PERFORMANCE;

EID: 84958811589     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3131-15.2016     Document Type: Article

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