Computational model of the fathead minnow hypothalamic-pituitary-gonadal axis: Incorporating protein synthesis in improving predictability of responses to endocrine active chemicals

Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology

Volumn 183-184, Issue , 2016, Pages 36-45

  Breen, Miyuki ^a   Villeneuve, Daniel L ^b   Ankley, Gerald T ^b   Bencic, David ^b   Breen, Michael S ^b   Watanabe, Karen H ^c   Lloyd, Alun L ^a   Conolly, Rory B ^d  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Adaptation; Computational model; Endocrine disrupting chemicals; Fadrozole; Fish; Hypothalamic pituitary gonadal axis; Protein synthesis; Toxicology

Indexed keywords

AROMATASE; ESTRADIOL; FADROZOLE; MESSENGER RNA; AROMATASE INHIBITOR; ENDOCRINE DISRUPTOR; FISH PROTEIN; WATER POLLUTANT;

ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; FEMALE; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; NONHUMAN; PIMEPHALES PROMELAS; PREDICTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; STRESS; ADMINISTRATION AND DOSAGE; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; BIOLOGY; BLOOD; CHEMISTRY; CYPRINIDAE; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MALE; METABOLISM; OVARY; PHYSIOLOGY; PROCEDURES; RANDOMIZATION; REPRODUCIBILITY; TESTIS; TOXICITY; TOXICITY TESTING; VALIDATION STUDY; WATER POLLUTANT;

ANIMALS; AROMATASE; AROMATASE INHIBITORS; COMPUTATIONAL BIOLOGY; CYPRINIDAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; ESTRADIOL; FADROZOLE; FEMALE; FISH PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MODELS, BIOLOGICAL; OVARY; RANDOM ALLOCATION; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; TESTIS; TOXICITY TESTS; WATER POLLUTANTS, CHEMICAL;

EID: 84958787555     PISSN: 15320456     EISSN: 18781659     Source Type: Journal    
DOI: 10.1016/j.cbpc.2016.02.002     Document Type: Article

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