Mitofusin 2 downregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PI3K/Akt and mitochondrial apoptosis pathways

Journal of Cardiovascular Pharmacology

Volumn 67, Issue 2, 2016, Pages 164-174

  Fang, Xia ^a   Chen, Xi ^a   Zhong, Guangwei ^a   Chen, Qiong ^a   Hu, Chengping ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Hypoxia induced pulmonary hypertension; Mitochondrial apoptosis pathway; Mitofusin 2; PI3K Akt; Pulmonary arterial smooth muscle cells

Indexed keywords

CASPASE 9; CYCLINE; CYTOCHROME C; MESSENGER RNA; MITOFUSIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MITOFUSIN 2 PROTEIN, RAT;

ADULT; AMBIENT AIR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERIOLE; ARTICLE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; G2 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; HYPOXIA-INDUCED PULMONARY HYPERTENSION; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PULMONARY ARTERY MUSCLE; PULMONARY ARTERY SMOOTH MUSCLE CELL; RANDOMIZATION; RAT; UPREGULATION; ANIMAL; CELL CULTURE; HEART MITOCHONDRION; HYPOXIA; METABOLISM; PATHOLOGY; PHYSIOLOGY; PULMONARY ARTERY; PULMONARY HYPERTENSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CELL; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DOWN-REGULATION; HYPERTENSION, PULMONARY; HYPOXIA; MALE; MEMBRANE PROTEINS; MITOCHONDRIA, HEART; MITOCHONDRIAL PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84958779883     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000333     Document Type: Article

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